AutismKB 2.0

Annotation Details for TFR2


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Basic Information Top
Gene Symbol:TFR2 ( HFE3,MGC126368,TFRC2 )
Gene Full Name: transferrin receptor 2
Band: 7q22.1
Quick LinksEntrez ID:7036; OMIM: 604720; Uniprot ID:TFR2_HUMAN; ENSEMBL ID: ENSG00000106327; HGNC ID: 11762
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886TAS-plasma membrane-
GO:0005887IGI-integral component of plasma membrane18353247
GO:0005887NAS-integral component of plasma membrane10409623
GO:0009897IGI-external side of plasma membrane18353247
GO:0031410IDA-cytoplasmic vesicle12704209
GO:1990712IDA-HFE-transferrin receptor complex12704209
GO ID Evidence Qualifier GO_term References
GO:0001948IPI-glycoprotein binding18353247
GO:0004998IDA-transferrin receptor activity18353247
GO:0004998NAS-transferrin receptor activity10409623
GO:0005515IPI-protein binding18353247
GO:0039706IPI-co-receptor binding22728873
GO ID Evidence Qualifier GO_term References
GO:0006826NAS-iron ion transport10409623
GO:0006879TAS-cellular iron ion homeostasis15319276
GO:0006898IGI-receptor-mediated endocytosis18353247
GO:0006953IEA-acute-phase response-
GO:0010039IMP-response to iron ion21173098
GO:0033572IGI-transferrin transport18353247
GO:0033572TAS-transferrin transport-
GO:0045807IGI-positive regulation of endocytosis18353247
GO:0045944IGI-positive regulation of transcription from RNA polymerase II promoter25635054
GO:0055072IC-iron ion homeostasis18353247
GO:0055072IMP-iron ion homeostasis21173098
GO:0071281IGI-cellular response to iron ion18353247
GO:0090277IMP-positive regulation of peptide hormone secretion21173098
GO:0098707IGI-ferrous iron import across plasma membrane18353247
GO:1903319IGI-positive regulation of protein maturation18353247
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TFR2HFE11289410638746 Co-crystal Structure
TFR2HFE10932510638746 Co-crystal Structure
TFR2TF11287611027676 Reconstituted Complex
TFR2TF11289411027676 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1354956
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-041220-3'