AutismKB 2.0

Annotation Details for TGFBR2


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Basic Information Top
Gene Symbol:TGFBR2 ( AAT3,FAA3,LDS1B,LDS2B,MFS2,RIIC,TAAD2,TGFR-2,TGFbeta-RII )
Gene Full Name: transforming growth factor, beta receptor II (70/80kDa)
Band: 3p24.1
Quick LinksEntrez ID:7048; OMIM: 190182; Uniprot ID:TGFR2_HUMAN; ENSEMBL ID: ENSG00000163513; HGNC ID: 11773
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane25893292
GO:0005886TAS-plasma membrane-
GO:0005901IDA-caveola17878231
GO:0009897IDA-external side of plasma membrane18453574
GO:0016021IDA-integral component of membrane7852346
GO:0043235IDA-receptor complex7852346
GO:0045121IDA-membrane raft25893292
GO:0070022IC-transforming growth factor beta receptor complex1326540
GO ID Evidence Qualifier GO_term References
GO:0004675IDA-transmembrane receptor protein serine/threonine kinase activity12015308
GO:0004702IEA-signal transducer, downstream of receptor, with serine/threonine kinase activity-
GO:0005024IC-transforming growth factor beta-activated receptor activity1326540
GO:0005024IDA-transforming growth factor beta-activated receptor activity7852346
GO:0005024IMP-transforming growth factor beta-activated receptor activity1333888
GO:0005026IEA-transforming growth factor beta receptor activity, type II-
GO:0005515IPI-protein binding7852346
GO:0005524IEA-ATP binding-
GO:0005539IDA-glycosaminoglycan binding7852346
GO:0031435IEA-mitogen-activated protein kinase kinase kinase binding-
GO:0034713IPI-type I transforming growth factor beta receptor binding1333888
GO:0046332IDA-SMAD binding11157754
GO:0046872IEA-metal ion binding-
GO:0050431IDA-transforming growth factor beta binding7852346
GO:0050431IPI-transforming growth factor beta binding1326540
GO:0050431IPIcontributes_totransforming growth factor beta binding7852346
GO ID Evidence Qualifier GO_term References
GO:0001568TAS-blood vessel development10092230
GO:0001569ISS-branching involved in blood vessel morphogenesis-
GO:0001570ISS-vasculogenesis-
GO:0001666IEA-response to hypoxia-
GO:0001701IEA-in utero embryonic development-
GO:0001947ISS-heart looping-
GO:0002053ISS-positive regulation of mesenchymal cell proliferation-
GO:0002088IEA-lens development in camera-type eye-
GO:0002651ISS-positive regulation of tolerance induction to self antigen-
GO:0002663ISS-positive regulation of B cell tolerance induction-
GO:0002666ISS-positive regulation of T cell tolerance induction-
GO:0003148ISS-outflow tract septum morphogenesis-
GO:0003149ISS-membranous septum morphogenesis-
GO:0003151ISS-outflow tract morphogenesis-
GO:0003181ISS-atrioventricular valve morphogenesis-
GO:0003186ISS-tricuspid valve morphogenesis-
GO:0003214ISS-cardiac left ventricle morphogenesis-
GO:0003274ISS-endocardial cushion fusion-
GO:0003430IEA-growth plate cartilage chondrocyte growth-
GO:0006468IDA-protein phosphorylation12015308
GO:0006898IEA-receptor-mediated endocytosis-
GO:0006915IDA-apoptotic process17471240
GO:0007179IC-transforming growth factor beta receptor signaling pathway1326540
GO:0007179IDA-transforming growth factor beta receptor signaling pathway18453574
GO:0007179IMP-transforming growth factor beta receptor signaling pathway1333888
GO:0007179TAS-transforming growth factor beta receptor signaling pathway-
GO:0007182IEA-common-partner SMAD protein phosphorylation-
GO:0007219IEA-Notch signaling pathway-
GO:0007224IEA-smoothened signaling pathway-
GO:0007369IEA-gastrulation-
GO:0007420ISS-brain development-
GO:0007507ISS-heart development-
GO:0007566IEA-embryo implantation-
GO:0007568IEA-aging-
GO:0007584IEA-response to nutrient-
GO:0008284TAS-positive regulation of cell proliferation7761852
GO:0009612IEA-response to mechanical stimulus-
GO:0009749IEA-response to glucose-
GO:0010468IEA-regulation of gene expression-
GO:0010634IEA-positive regulation of epithelial cell migration-
GO:0010718IDA-positive regulation of epithelial to mesenchymal transition26459119
GO:0018105IDA-peptidyl-serine phosphorylation12015308
GO:0018107IDA-peptidyl-threonine phosphorylation12015308
GO:0023014IEA-signal transduction by protein phosphorylation-
GO:0030512TAS-negative regulation of transforming growth factor beta receptor signaling pathway-
GO:0031100IEA-animal organ regeneration-
GO:0032147ISS-activation of protein kinase activity-
GO:0035162ISS-embryonic hemopoiesis-
GO:0042060IEA-wound healing-
GO:0042127ISS-regulation of cell proliferation-
GO:0042493IDA-response to drug17878231
GO:0043011ISS-myeloid dendritic cell differentiation-
GO:0043415IEA-positive regulation of skeletal muscle tissue regeneration-
GO:0043627IEA-response to estrogen-
GO:0045766IEA-positive regulation of angiogenesis-
GO:0048545IEA-response to steroid hormone-
GO:0048565IEA-digestive tract development-
GO:0048661IEA-positive regulation of smooth muscle cell proliferation-
GO:0048701ISS-embryonic cranial skeleton morphogenesis-
GO:0051138ISS-positive regulation of NK T cell differentiation-
GO:0060021ISS-palate development-
GO:0060044IEA-negative regulation of cardiac muscle cell proliferation-
GO:0060389IDA-pathway-restricted SMAD protein phosphorylation18453574
GO:0060412ISS-ventricular septum morphogenesis-
GO:0060434IEA-bronchus morphogenesis-
GO:0060440IEA-trachea formation-
GO:0060443IEA-mammary gland morphogenesis-
GO:0060463IEA-lung lobe morphogenesis-
GO:0070723IDA-response to cholesterol17878231
GO:1905007ISS-positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation-
GO:1905315ISSNOTcell proliferation involved in endocardial cushion morphogenesis-
GO:1990086IEA-lens fiber cell apoptotic process-
GO:2000379IMP-positive regulation of reactive oxygen species metabolic process20160708
GO:2000563IDA-positive regulation of CD4-positive, alpha-beta T cell proliferation17164348
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TGFBR2ACVR11129067890683 Two-hybrid
TGFBR2ACVR11066057890683 Two-hybrid
TGFBR2AP2B111290612429842 Affinity Capture-Western; Two-hybrid
TGFBR2AP2B110667212429842 Affinity Capture-Western; Two-hybrid
TGFBR2CCNB11129069926943 Reconstituted Complex
TGFBR2CCNB11073329926943 Reconstituted Complex
TGFBR2CLU1076038555189 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TGFBR2CLU1129068555189 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TGFBR2CTNNB111290612000714 Affinity Capture-Western
TGFBR2CTNNB110788012000714 Affinity Capture-Western
TGFBR2DAB211290611387212 Affinity Capture-Western
TGFBR2DAB210797111387212 Affinity Capture-Western
TGFBR2ENG1129069872992 12015308 Affinity Capture-Western; Biochemical Activity
TGFBR2ENG1083379872992 12015308 Affinity Capture-Western; Biochemical Activity
TGFBR2HSP90AA111290618591668 Affinity Capture-Western; Reconstituted Complex
TGFBR2HSP90AA110955218591668 Affinity Capture-Western; Reconstituted Complex
TGFBR2SMAD711290611163210 Affinity Capture-Western
TGFBR2SMAD711026711163210 Affinity Capture-Western
TGFBR2PIK3R11129069435577 Affinity Capture-Western
TGFBR2PIK3R11113139435577 Affinity Capture-Western
TGFBR2PIK3R21129069435577 Affinity Capture-Western
TGFBR2PIK3R21113149435577 Affinity Capture-Western
TGFBR2TGFB111290611157754 Affinity Capture-Western
TGFBR2TGFB111289811157754 Affinity Capture-Western
TGFBR2TGFB211290611157754 Affinity Capture-Western
TGFBR2TGFB211290011157754 Affinity Capture-Western
TGFBR2TGFB31129069872992 11157754 11850637 12729750 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
TGFBR2TGFB31129019872992 11157754 11850637 12729750 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
TGFBR2TGFBR11129067890683 11102446 Co-fractionation; Two-hybrid
TGFBR2TGFBR11129047890683 11102446 Co-fractionation; Two-hybrid
TGFBR3TGFBR21129068106553 Affinity Capture-Western
TGFBR3TGFBR21129078106553 Affinity Capture-Western
STRAPTGFBR21129069856985 10757800 Affinity Capture-Western
STRAPTGFBR21163429856985 10757800 Affinity Capture-Western
CCNB2TGFBR21129069926943 Reconstituted Complex
CCNB2TGFBR21145819926943 Reconstituted Complex
SMURF2TGFBR211290611163210 Affinity Capture-Western
SMURF2TGFBR212226511163210 Affinity Capture-Western
SNX6TGFBR211290611279102 Affinity Capture-Western
SNX6TGFBR212185211279102 Affinity Capture-Western
UBCTGFBR211290618448069 Affinity Capture-Western
UBCTGFBR211316418448069 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
TGFBR2PPP1CA21794715761153 T-beta-RII interacts with an unspecific isoform of PPP1C. This interaction was modeled on a demonstrated interaction between human T-beta-RII and mouse PPP1C.
Gene Symbol Interactant Interaction ID References Description
TGFBR2TGFB1I10182312421567 -
TGFBR2TGFB1I10383112421567 -
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
TGFBR2rs12487185, rs1367609, rs1864615, rs2276767, rs3087465, rs3773652, rs3773663, rs4522809, rs7625858, rs7648606 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:98729
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-980526-375'