AutismKB 2.0

Annotation Details for TGM2


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Basic Information Top
Gene Symbol:TGM2 ( G-ALPHA-h,GNAH,TG2,TGC )
Gene Full Name: transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
Band: 20q11.23
Quick LinksEntrez ID:7052; OMIM: 190196; Uniprot ID:TGM2_HUMAN; ENSEMBL ID: ENSG00000198959; HGNC ID: 11778
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005739IDA-mitochondrion24349085
GO:0005783IEA-endoplasmic reticulum-
GO:0005829IDA-cytosol24349085
GO:0005925IDA-focal adhesion21423176
GO:0031012IDA-extracellular matrix23979707
GO:0031226IDA-intrinsic component of plasma membrane2578891
GO:0031226IMP-intrinsic component of plasma membrane8105889
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0003810IMP-protein-glutamine gamma-glutamyltransferase activity24349085
GO:0003810ISS-protein-glutamine gamma-glutamyltransferase activity-
GO:0005515IPI-protein binding9442029
GO:0005525IEA-GTP binding-
GO:0019904IEA-protein domain specific binding-
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0001974IEA-blood vessel remodeling-
GO:0018153IEA-isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine-
GO:0032471IMP-negative regulation of endoplasmic reticulum calcium ion concentration24349085
GO:0043065IMP-positive regulation of apoptotic process24349085
GO:0043123IEA-positive regulation of I-kappaB kinase/NF-kappaB signaling-
GO:0043277IDA-apoptotic cell clearance19628791
GO:0045785ISS-positive regulation of cell adhesion-
GO:0048661IEA-positive regulation of smooth muscle cell proliferation-
GO:0050729IEA-positive regulation of inflammatory response-
GO:0051260IEA-protein homooligomerization-
GO:0051482IEA-positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway-
GO:0051561IMP-positive regulation of mitochondrial calcium ion concentration24349085
GO:0060445IEA-branching involved in salivary gland morphogenesis-
GO:0060662IEA-salivary gland cavitation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TGM2FN110862111829448 Reconstituted Complex
TGM2FN111291011829448 Reconstituted Complex
TGM2GSTP11092059973324 Affinity Capture-Western
TGM2GSTP11129109973324 Affinity Capture-Western
TGM2KPNA411291010100610 Affinity Capture-Western
TGM2KPNA411003810100610 Affinity Capture-Western
TGM2PLCD11129109512491 Affinity Capture-Western
TGM2PLCD11113499512491 Affinity Capture-Western
TGM2RB11129109315663 Affinity Capture-Western
TGM2RB11118609315663 Affinity Capture-Western
TGM2TGM211291011867708 Co-crystal Structure
Gene Symbol Interactant Interaction ID References Description
TGM2HTT12820811442349 Htt interacts with tTG.
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
TGM2rs1555074, rs17789815, rs2076380, rs2268909, rs2284879, rs4811528, rs6023526, rs7270785 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:98731
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-2576'