AutismKB 2.0

Annotation Details for TH


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Basic Information Top
Gene Symbol:TH ( DYT14,DYT5b,TYH )
Gene Full Name: tyrosine hydroxylase
Band: 11p15.5
Quick LinksEntrez ID:7054; OMIM: 191290; Uniprot ID:TY3H_HUMAN; ENSEMBL ID: ENSG00000180176; HGNC ID: 11782
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634ISS-nucleus-
GO:0005737IDA-cytoplasm10907721
GO:0005739IEA-mitochondrion-
GO:0005790IDA-smooth endoplasmic reticulum12457228
GO:0005829TAS-cytosol-
GO:0008021IEA-synaptic vesicle-
GO:0009898IDA-cytoplasmic side of plasma membrane12457228
GO:0030425IEA-dendrite-
GO:0031410IDA-cytoplasmic vesicle12457228
GO:0033162IDA-melanosome membrane12631248
GO:0043005IDA-neuron projection17135716
GO:0043195IEA-terminal bouton-
GO:0043204ISS-perikaryon-
GO ID Evidence Qualifier GO_term References
GO:0004511IDA-tyrosine 3-monooxygenase activity2896667
GO:0004511TAS-tyrosine 3-monooxygenase activity-
GO:0005515IPI-protein binding11943812
GO:0008198IEA-ferrous iron binding-
GO:0008199IEA-ferric iron binding-
GO:0016597IEA-amino acid binding-
GO:0019825IEA-oxygen binding-
GO:0019899IPI-enzyme binding19703902
GO:0019904IEA-protein domain specific binding-
GO:0034617IEA-tetrahydrobiopterin binding-
GO:0035240IEA-dopamine binding-
GO ID Evidence Qualifier GO_term References
GO:0001666IDA-response to hypoxia17520326
GO:0001963ISS-synaptic transmission, dopaminergic-
GO:0001975IEA-response to amphetamine-
GO:0003007NAS-heart morphogenesis12113410
GO:0006585NAS-dopamine biosynthetic process from tyrosine10907721
GO:0006631IEA-fatty acid metabolic process-
GO:0006665IEA-sphingolipid metabolic process-
GO:0007507ISS-heart development-
GO:0007601ISS-visual perception-
GO:0007605IEA-sensory perception of sound-
GO:0007612ISS-learning-
GO:0007613ISS-memory-
GO:0007617IEA-mating behavior-
GO:0007626ISS-locomotory behavior-
GO:0008016ISS-regulation of heart contraction-
GO:0009414IEA-response to water deprivation-
GO:0009416IEA-response to light stimulus-
GO:0009635IEA-response to herbicide-
GO:0009651IEA-response to salt stress-
GO:0009653TAS-anatomical structure morphogenesis7715703
GO:0009887ISS-animal organ morphogenesis-
GO:0010043IEA-response to zinc ion-
GO:0010259IEA-multicellular organism aging-
GO:0014823IEA-response to activity-
GO:0015842IEA-aminergic neurotransmitter loading into synaptic vesicle-
GO:0016137IEA-glycoside metabolic process-
GO:0018963IEA-phthalate metabolic process-
GO:0021987IEA-cerebral cortex development-
GO:0031667IEA-response to nutrient levels-
GO:0032355IEA-response to estradiol-
GO:0032496IEA-response to lipopolysaccharide-
GO:0033076IEA-isoquinoline alkaloid metabolic process-
GO:0035176IEA-social behavior-
GO:0035690IEA-cellular response to drug-
GO:0035900IEA-response to isolation stress-
GO:0035902IEA-response to immobilization stress-
GO:0042136IEA-neurotransmitter biosynthetic process-
GO:0042214IEA-terpene metabolic process-
GO:0042416IDA-dopamine biosynthetic process12457228
GO:0042418IDA-epinephrine biosynthetic process12457228
GO:0042421IDA-norepinephrine biosynthetic process12457228
GO:0042423TAS-catecholamine biosynthetic process-
GO:0042462ISS-eye photoreceptor cell development-
GO:0042745IEA-circadian sleep/wake cycle-
GO:0042755IEA-eating behavior-
GO:0043434IEA-response to peptide hormone-
GO:0043473TAS-pigmentation12631248
GO:0045471IDA-response to ethanol18343820
GO:0045472IEA-response to ether-
GO:0046684IEA-response to pyrethroid-
GO:0048596ISS-embryonic camera-type eye morphogenesis-
GO:0051412IEA-response to corticosterone-
GO:0051602IEA-response to electrical stimulus-
GO:0052314IEA-phytoalexin metabolic process-
GO:0055114IEA-oxidation-reduction process-
GO:0071287IEA-cellular response to manganese ion-
GO:0071316IEA-cellular response to nicotine-
GO:0071333IEA-cellular response to glucose stimulus-
GO:0071363IEA-cellular response to growth factor stimulus-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
THMAPK11115801347949 Biochemical Activity
THMAPK11129121347949 Biochemical Activity
THMAPK31129121347949 Biochemical Activity
THMAPK31115811347949 Biochemical Activity
No data
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
THTH_2bpSTR, rs2070762, rs6356 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
THTH_IVS8nt8, rs10840491, rs10840495, rs1800033, rs2070762, rs28934579, rs6356, rs71029110, rs7396243, rs7482891 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:98735
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-990621-5'