AutismKB 2.0

Annotation Details for THBS1


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Basic Information Top
Gene Symbol:THBS1 ( THBS,THBS-1,TSP,TSP-1,TSP1 )
Gene Full Name: thrombospondin 1
Band: 15q14
Quick LinksEntrez ID:7057; OMIM: 188060; Uniprot ID:TSP1_HUMAN; ENSEMBL ID: ENSG00000137801; HGNC ID: 11785
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005577IDA-fibrinogen complex3997886
GO:0005615IDA-extracellular space6777381
GO:0005783ISS-endoplasmic reticulum-
GO:0005788TAS-endoplasmic reticulum lumen-
GO:0009897IDA-external side of plasma membrane6777381
GO:0009986IDA-cell surface2435757
GO:0016529ISS-sarcoplasmic reticulum-
GO:0030141IDA-secretory granule101549
GO:0031012IDA-extracellular matrix23658023
GO:0031012IDAcolocalizes_withextracellular matrix20551380
GO:0031012ISScolocalizes_withextracellular matrix22261194
GO:0031012TAS-extracellular matrix9304800
GO:0031091IDA-platelet alpha granule6777381
GO:0031093TAS-platelet alpha granule lumen-
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0001786IDA-phosphatidylserine binding18940719
GO:0001948NAS-glycoprotein binding6438154
GO:0001968IDA-fibronectin binding6693501
GO:0005178IMP-integrin binding17413041
GO:0005509NAS-calcium ion binding9304800
GO:0005515IPI-protein binding3402455
GO:0008201IDA-heparin binding101549
GO:0017134IDA-fibroblast growth factor binding17996481
GO:0030169IDA-low-density lipoprotein particle binding6693501
GO:0042802NAS-identical protein binding9304800
GO:0043236IDA-laminin binding6693501
GO:0043394TAS-proteoglycan binding9304800
GO:0050431ISS-transforming growth factor beta binding-
GO:0050431TAS-transforming growth factor beta binding9304800
GO:0070051IDA-fibrinogen binding6693501
GO:0070052IDA-collagen V binding6693501
GO ID Evidence Qualifier GO_term References
GO:0000187IMP-activation of MAPK activity17413041
GO:0001666NAS-response to hypoxia9304800
GO:0001937IDA-negative regulation of endothelial cell proliferation16150726
GO:0001937IMP-negative regulation of endothelial cell proliferation17413041
GO:0001953IDA-negative regulation of cell-matrix adhesion16150726
GO:0002040IMP-sprouting angiogenesis17879962
GO:0002544IEP-chronic inflammatory response18674744
GO:0002576TAS-platelet degranulation-
GO:0002581IDA-negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II16882710
GO:0002605IDA-negative regulation of dendritic cell antigen processing and presentation16882710
GO:0006954IDA-inflammatory response23144964
GO:0006955IEP-immune response18674744
GO:0006986IEA-response to unfolded protein-
GO:0007050IDA-cell cycle arrest17596205
GO:0007155NAS-cell adhesion9304800
GO:0008284IDA-positive regulation of cell proliferation24615654
GO:0009612IEA-response to mechanical stimulus-
GO:0009749IDA-response to glucose18096704
GO:0010595IDA-positive regulation of endothelial cell migration18555217
GO:0010596IDA-negative regulation of endothelial cell migration18555217
GO:0010748IDA-negative regulation of plasma membrane long-chain fatty acid transport17416590
GO:0010751IDA-negative regulation of nitric oxide mediated signal transduction16150726
GO:0010754IDA-negative regulation of cGMP-mediated signaling17416590
GO:0010757IDA-negative regulation of plasminogen activation6438154
GO:0010759ISS-positive regulation of macrophage chemotaxis-
GO:0010763IDA-positive regulation of fibroblast migration18555217
GO:0016477IDA-cell migration18555217
GO:0016525IDA-negative regulation of angiogenesis16150726
GO:0018149IDA-peptide cross-linking3997886
GO:0030194IDA-positive regulation of blood coagulation3997886
GO:0030198TAS-extracellular matrix organization-
GO:0030335IDA-positive regulation of cell migration15700281
GO:0030335IMP-positive regulation of cell migration17413041
GO:0030511IDA-positive regulation of transforming growth factor beta receptor signaling pathway18555217
GO:0030823IDA-regulation of cGMP metabolic process16150726
GO:0032026IDA-response to magnesium ion6777381
GO:0032570TAS-response to progesterone9304800
GO:0032695IDA-negative regulation of interleukin-12 production16882710
GO:0032914ISS-positive regulation of transforming growth factor beta1 production-
GO:0033574IEA-response to testosterone-
GO:0034605NAS-cellular response to heat9304800
GO:0034976ISS-response to endoplasmic reticulum stress-
GO:0036066TAS-protein O-linked fucosylation-
GO:0040037IDA-negative regulation of fibroblast growth factor receptor signaling pathway17996481
GO:0042327IMP-positive regulation of phosphorylation17413041
GO:0042493IEP-response to drug19738618
GO:0042535IDA-positive regulation of tumor necrosis factor biosynthetic process18726995
GO:0043032IDA-positive regulation of macrophage activation18757424
GO:0043066IDA-negative regulation of apoptotic process18653767
GO:0043154IDA-negative regulation of cysteine-type endopeptidase activity involved in apoptotic process18653767
GO:0043536IDA-positive regulation of blood vessel endothelial cell migration18555217
GO:0043537IDA-negative regulation of blood vessel endothelial cell migration18555217
GO:0043652IDA-engulfment of apoptotic cell16882710
GO:0045727IDA-positive regulation of translation15700281
GO:0045766IMP-positive regulation of angiogenesis17413041
GO:0048266ISS-behavioral response to pain-
GO:0048661IDA-positive regulation of smooth muscle cell proliferation24615654
GO:0050921IDA-positive regulation of chemotaxis18555217
GO:0051592IDA-response to calcium ion6777381
GO:0051895TAS-negative regulation of focal adhesion assembly9304800
GO:0051897IDA-positive regulation of protein kinase B signaling18653767
GO:0051918IDA-negative regulation of fibrinolysis6438154
GO:0071356IEA-cellular response to tumor necrosis factor-
GO:0071363IEA-cellular response to growth factor stimulus-
GO:1902043IDA-positive regulation of extrinsic apoptotic signaling pathway via death domain receptors18726995
GO:2000353IDA-positive regulation of endothelial cell apoptotic process18726995
GO:2000379IDA-positive regulation of reactive oxygen species metabolic process18757424
GO:2001027IDA-negative regulation of endothelial cell chemotaxis16150726
GO:2001237TAS-negative regulation of extrinsic apoptotic signaling pathway17879962
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
THBS1CALCR10725012147682 Reconstituted Complex
THBS1CALCR11291512147682 Reconstituted Complex
THBS1SCARB21129159478926 Reconstituted Complex
THBS1SCARB21073889478926 Reconstituted Complex
THBS1COL1A11129153571333 Reconstituted Complex
THBS1COL1A11076743571333 Reconstituted Complex
THBS1COL2A11129153571333 Reconstituted Complex
THBS1COL2A11076773571333 Reconstituted Complex
THBS1COL3A11129153571333 Reconstituted Complex
THBS1COL3A11076783571333 Reconstituted Complex
THBS1COL4A11076793571333 Reconstituted Complex
THBS1COL4A11129153571333 Reconstituted Complex
THBS1COL5A11076863571333 Reconstituted Complex
THBS1COL5A11129153571333 Reconstituted Complex
THBS1COL7A11076919840442 Two-hybrid
THBS1COL7A11129159840442 Two-hybrid
THBS1DHFR10806510749676 Reconstituted Complex
THBS1DHFR11291510749676 Reconstituted Complex
THBS1ELANE1129158463250 Reconstituted Complex
THBS1ELANE1083068463250 Reconstituted Complex
THBS1F21129152435757 Reconstituted Complex
THBS1F21084472435757 Reconstituted Complex
THBS1FGA1085349867861 Reconstituted Complex
THBS1FGA1129159867861 Reconstituted Complex
THBS1IGFBP510970910698186 Reconstituted Complex
THBS1IGFBP511291510698186 Reconstituted Complex
THBS1ITGB31129152478219 Reconstituted Complex
THBS1ITGB31098962478219 Reconstituted Complex
THBS1LRP11129157775583 9045712 14991768 Reconstituted Complex
THBS1LRP11102157775583 9045712 14991768 Reconstituted Complex
THBS1LRP21102167775583 Reconstituted Complex
THBS1LRP21129157775583 Reconstituted Complex
THBS1MMP211291510900205 Affinity Capture-Western; Two-hybrid
THBS1MMP211045710900205 Affinity Capture-Western; Two-hybrid
THBS1MMP911291510900205 Affinity Capture-Western
THBS1MMP911046110900205 Affinity Capture-Western
THBS1PDGFB1129159334164 Reconstituted Complex
THBS1PDGFB1111819334164 Reconstituted Complex
THBS1PLG1113562522013 6438154 Reconstituted Complex
THBS1PLG1129152522013 6438154 Reconstituted Complex
THBS1TFPI11289310922378 Reconstituted Complex
THBS1TFPI11291510922378 Reconstituted Complex
THBS1TGFB11129151550960 Co-purification
THBS1TGFB11128981550960 Co-purification
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:98737
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-020708-1'