AutismKB 2.0

Annotation Details for THRA


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Basic Information Top
Gene Symbol:THRA ( AR7,EAR7,ERB-T-1,ERBA,ERBA1,MGC000261,MGC43240,NR1A1,THRA1,THRA2,c-ERBA-1 )
Gene Full Name: thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
Band: 17q21.1
Quick LinksEntrez ID:7067; OMIM: 190120; Uniprot ID:THA_HUMAN; ENSEMBL ID: ENSG00000126351; HGNC ID: 11796
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus8710870
GO:0005654TAS-nucleoplasm-
GO:0005829IDA-cytosol19158403
GO ID Evidence Qualifier GO_term References
GO:0000976IEA-transcription regulatory region sequence-specific DNA binding-
GO:0002153IEA-steroid receptor RNA activator RNA binding-
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding8710870
GO:0003707IEA-steroid hormone receptor activity-
GO:0004887IDA-thyroid hormone receptor activity8710870
GO:0005515IPI-protein binding9653119
GO:0008134IPI-transcription factor binding8524305
GO:0008270IEA-zinc ion binding-
GO:0017025IDA-TBP-class protein binding8524305
GO:0019904IPI-protein domain specific binding9653119
GO:0031490IEA-chromatin DNA binding-
GO:0032403IEA-protein complex binding-
GO:0044212IDA-transcription regulatory region DNA binding18052923
GO:0070324IDA-thyroid hormone binding8710870
GO:0070324IPI-thyroid hormone binding2879243
GO ID Evidence Qualifier GO_term References
GO:0001502IEA-cartilage condensation-
GO:0001503IEA-ossification-
GO:0002155IEA-regulation of thyroid hormone mediated signaling pathway-
GO:0006357IDA-regulation of transcription from RNA polymerase II promoter18052923
GO:0006366IDA-transcription from RNA polymerase II promoter8710870
GO:0006367TAS-transcription initiation from RNA polymerase II promoter-
GO:0007611IEA-learning or memory-
GO:0008016IEA-regulation of heart contraction-
GO:0008050IEA-female courtship behavior-
GO:0009409IEA-response to cold-
GO:0009755IDA-hormone-mediated signaling pathway18052923
GO:0010831IEA-positive regulation of myotube differentiation-
GO:0017055IDA-negative regulation of RNA polymerase II transcriptional preinitiation complex assembly8524305
GO:0030218IEA-erythrocyte differentiation-
GO:0030522IEA-intracellular receptor signaling pathway-
GO:0030878IEA-thyroid gland development-
GO:0033032IEA-regulation of myeloid cell apoptotic process-
GO:0042994IEA-cytoplasmic sequestering of transcription factor-
GO:0043401IEA-steroid hormone mediated signaling pathway-
GO:0045892IDA-negative regulation of transcription, DNA-templated8710870
GO:0045925IEA-positive regulation of female receptivity-
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0050994IEA-regulation of lipid catabolic process-
GO:0060509IEA-Type I pneumocyte differentiation-
GO:2000143IDA-negative regulation of DNA-templated transcription, initiation8524305
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
THRAPARP110665215808511 Affinity Capture-Western
THRAPARP111292315808511 Affinity Capture-Western
THRACCND110706712048199 Affinity Capture-Western
THRACCND111292312048199 Affinity Capture-Western
THRACDK810745810198638 Affinity Capture-Western
THRACDK811292310198638 Affinity Capture-Western
THRAEMD10832517620012 Affinity Capture-MS
THRAEMD11292317620012 Affinity Capture-MS
THRAEP30010834712371907 Affinity Capture-Western
THRAEP30011292312371907 Affinity Capture-Western
THRAFUS1087979440806 Reconstituted Complex
THRAFUS1129239440806 Reconstituted Complex
THRAMEF2A11036912371907 Affinity Capture-Western; Reconstituted Complex
THRAMEF2A11292312371907 Affinity Capture-Western; Reconstituted Complex
THRAPOU2F111144710480874 Reconstituted Complex
THRAPOU2F111292310480874 Reconstituted Complex
THRAMED11114659653119 10037764 10733574 11117530 Affinity Capture-Western; Far Western; Reconstituted Complex
THRAMED11129239653119 10037764 10733574 11117530 Affinity Capture-Western; Far Western; Reconstituted Complex
THRARXRA1129231314167 11117530 Affinity Capture-Western; Co-purification
THRARXRA1121681314167 11117530 Affinity Capture-Western; Co-purification
THRASRC11259215140878 Reconstituted Complex
THRASRC11292315140878 Reconstituted Complex
THRASUV39H111270612138181 Reconstituted Complex
THRASUV39H111292312138181 Reconstituted Complex
THRATAF711292310409738 Affinity Capture-Western
THRATAF711274210409738 Affinity Capture-Western
THRATAF1111274510744685 Affinity Capture-Western; Two-hybrid
THRATAF1111292310744685 Affinity Capture-Western; Two-hybrid
THRATDG11292312874288 Reconstituted Complex
THRATDG11285512874288 Reconstituted Complex
NR0B2THRA1140128650544 Reconstituted Complex
NR0B2THRA1129238650544 Reconstituted Complex
TRIM24THRA1143339115274 Reconstituted Complex
TRIM24THRA1129239115274 Reconstituted Complex
TRIP11THRA1147329256431 Affinity Capture-Western; Reconstituted Complex
TRIP11THRA1129239256431 Affinity Capture-Western; Reconstituted Complex
NCOR2THRA1149749415406 Far Western
NCOR2THRA1129239415406 Far Western
NRIP1THRA1138439626662 10379889 15130509 Reconstituted Complex
NRIP1THRA1129239626662 10379889 15130509 Reconstituted Complex
AKAP13THRA1163839627117 Reconstituted Complex
AKAP13THRA1129239627117 Reconstituted Complex
NCOA1THRA1142009804773 9849963 10379889 11117530 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOA1THRA1129239804773 9849963 10379889 11117530 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOR1THRA1149739804773 9849963 11889044 15131262 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOR1THRA1129239804773 9849963 11889044 15131262 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GRIP1THRA1129239849963 10379889 Reconstituted Complex; Two-hybrid
GRIP1THRA1169959849963 10379889 Reconstituted Complex; Two-hybrid
MED6THRA11531910198638 Affinity Capture-MS; Affinity Capture-Western
MED6THRA11292310198638 Affinity Capture-MS; Affinity Capture-Western
MED16THRA11292310198638 Affinity Capture-MS; Affinity Capture-Western
MED16THRA11534210198638 Affinity Capture-MS; Affinity Capture-Western
MED12THRA11529310198638 Affinity Capture-MS; Affinity Capture-Western
MED12THRA11292310198638 Affinity Capture-MS; Affinity Capture-Western
MED21THRA11292310198638 Affinity Capture-Western
MED21THRA11480710198638 Affinity Capture-Western
MED24THRA11519610198638 11117530 Affinity Capture-Western
MED24THRA11292310198638 11117530 Affinity Capture-Western
COPS2THRA11472910207062 10877839 Reconstituted Complex; Two-hybrid
COPS2THRA11292310207062 10877839 Reconstituted Complex; Two-hybrid
ITGB3BPTHRA11292310490654 11713274 Reconstituted Complex; Two-hybrid
ITGB3BPTHRA11699210490654 11713274 Reconstituted Complex; Two-hybrid
NCOA6THRA11292310567404 10847592 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOA6THRA11669110567404 10847592 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
DAP3THRA11358710903152 Reconstituted Complex
DAP3THRA11292310903152 Reconstituted Complex
NCOA2THRA11576111117530 Affinity Capture-Western
NCOA2THRA11292311117530 Affinity Capture-Western
NCOA3THRA11384111117530 Affinity Capture-Western
NCOA3THRA11292311117530 Affinity Capture-Western
YWHAQTHRA11616811266503 Reconstituted Complex
YWHAQTHRA11292311266503 Reconstituted Complex
HRTHRA11292311641275 Affinity Capture-Western
HRTHRA12091711641275 Affinity Capture-Western
HDAC3THRA11436811889044 Affinity Capture-Western
HDAC3THRA11292311889044 Affinity Capture-Western
UBCTHRA11316418655026 Affinity Capture-MS; Affinity Capture-Western
UBCTHRA11292318655026 Affinity Capture-MS; Affinity Capture-Western
ZBTB3THRA12293320211142 Two-hybrid
ZBTB3THRA11292320211142 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
THRArs1568400, rs3744805, rs7502966, rs868150, rs939348 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:98742
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-060613-1'