AutismKB 2.0

Annotation Details for TIAM1


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Basic Information Top
Gene Symbol:TIAM1 ( FLJ36302 )
Gene Full Name: T-cell lymphoma invasion and metastasis 1
Band: 21q22.11
Quick LinksEntrez ID:7074; OMIM: 600687; Uniprot ID:TIAM1_HUMAN; ENSEMBL ID: ENSG00000156299; HGNC ID: 11805
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IEA-nucleus-
GO:0005829IDA-cytosol23109420
GO:0005829TAS-cytosol-
GO:0005874IEA-microtubule-
GO:0005886IDA-plasma membrane23109420
GO:0005911IDA-cell-cell junction20332120
GO:0014069IEA-postsynaptic density-
GO:0031234IDA-extrinsic component of cytoplasmic side of plasma membrane20361982
GO:0032587IEA-ruffle membrane-
GO:0043025IEA-neuronal cell body-
GO:0043197IEA-dendritic spine-
GO:0044291IDA-cell-cell contact zone20361982
GO:0044295IEA-axonal growth cone-
GO:0044304IEA-main axon-
GO ID Evidence Qualifier GO_term References
GO:0005057IEA-signal transducer activity, downstream of receptor-
GO:0005085EXP-guanyl-nucleotide exchange factor activity15721239
GO:0005085TAS-guanyl-nucleotide exchange factor activity-
GO:0005089TAS-Rho guanyl-nucleotide exchange factor activity-
GO:0005515IPI-protein binding23109420
GO:0008017IEA-microtubule binding-
GO:0008289IEA-lipid binding-
GO:0019900IPI-kinase binding23109420
GO:0030676IDA-Rac guanyl-nucleotide exchange factor activity23109420
GO:0030676IMP-Rac guanyl-nucleotide exchange factor activity20361982
GO:0030971IEA-receptor tyrosine kinase binding-
GO:0048365IEA-Rac GTPase binding-
GO ID Evidence Qualifier GO_term References
GO:0003300IEA-cardiac muscle hypertrophy-
GO:0006915IEA-apoptotic process-
GO:0007160IMP-cell-matrix adhesion20361982
GO:0008284IDA-positive regulation of cell proliferation25032858
GO:0010717IDA-regulation of epithelial to mesenchymal transition20826792
GO:0010718NAS-positive regulation of epithelial to mesenchymal transition17086355
GO:0016477IMP-cell migration20361982
GO:0016601IMP-Rac protein signal transduction20361982
GO:0030335IDA-positive regulation of cell migration25032858
GO:0032092IDA-positive regulation of protein binding23109420
GO:0035023IEA-regulation of Rho protein signal transduction-
GO:0042220IEA-response to cocaine-
GO:0043065TAS-positive regulation of apoptotic process-
GO:0043507IEA-positive regulation of JUN kinase activity-
GO:0048013TAS-ephrin receptor signaling pathway-
GO:0050772IEA-positive regulation of axonogenesis-
GO:0051056TAS-regulation of small GTPase mediated signal transduction-
GO:0060071NAS-Wnt signaling pathway, planar cell polarity pathway24431302
GO:0061003IEA-positive regulation of dendritic spine morphogenesis-
GO:0061178IEA-regulation of insulin secretion involved in cellular response to glucose stimulus-
GO:0070372IEA-regulation of ERK1 and ERK2 cascade-
GO:0072657IEA-protein localization to membrane-
GO:0090630IDA-activation of GTPase activity23109420
GO:0098989IEA-NMDA selective glutamate receptor signaling pathway-
GO:1904268IEA-positive regulation of Schwann cell chemotaxis-
GO:1904338ISS-regulation of dopaminergic neuron differentiation-
GO:1905274IEA-regulation of modification of postsynaptic actin cytoskeleton-
GO:1990138IEA-neuron projection extension-
GO:2000050ISS-regulation of non-canonical Wnt signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TIAM1ANK111293010893266 Affinity Capture-Western; Reconstituted Complex
TIAM1ANK110678310893266 Affinity Capture-Western; Reconstituted Complex
TIAM1ANK311293010893266 Affinity Capture-Western
TIAM1ANK310678510893266 Affinity Capture-Western
TIAM1CD4410739810636882 Reconstituted Complex
TIAM1CD4411293010636882 Reconstituted Complex
TIAM1HRAS10950112134164 Affinity Capture-Western
TIAM1HRAS11293012134164 Affinity Capture-Western
TIAM1MYC11293012446731 Affinity Capture-Western; Reconstituted Complex
TIAM1MYC11069412446731 Affinity Capture-Western; Reconstituted Complex
TIAM1NME111293011274357 Affinity Capture-Western
TIAM1NME111089411274357 Affinity Capture-Western
TIAM1PRKCA11293010212259 Biochemical Activity
TIAM1PRKCA11156410212259 Biochemical Activity
TIAM1PRKCB11293010212259 Biochemical Activity
TIAM1PRKCB11156510212259 Biochemical Activity
TIAM1PRKCD11156610212259 Biochemical Activity
TIAM1PRKCD11293010212259 Biochemical Activity
TIAM1PRKCE11156710212259 Biochemical Activity
TIAM1PRKCE11293010212259 Biochemical Activity
TIAM1PRKCG11156810212259 Biochemical Activity
TIAM1PRKCG11293010212259 Biochemical Activity
TIAM1PRKCZ11157610212259 Biochemical Activity
TIAM1PRKCZ11293010212259 Biochemical Activity
TIAM1RAC111181711130063 11595749 Co-crystal Structure; Reconstituted Complex
TIAM1RAC111293011130063 11595749 Co-crystal Structure; Reconstituted Complex
MAPK8IP2TIAM111293012024021 Affinity Capture-Western
MAPK8IP2TIAM111708612024021 Affinity Capture-Western
MAPK8IP1TIAM111486412024021 Affinity Capture-Western
MAPK8IP1TIAM111293012024021 Affinity Capture-Western
PPP1R9BTIAM112420212531897 Affinity Capture-Western; Two-hybrid
PPP1R9BTIAM111293012531897 Affinity Capture-Western; Two-hybrid
Gene Symbol Interactant Interaction ID References Description
TIAM1GRIN121540215721239 Tiam1 interacts with NMDA subunit NR1. This interaction was modelled on a demonstrated interaction between human Tiam1 and NR1 from an unspecified species.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:103306
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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