AutismKB 2.0

Annotation Details for TIMP1


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Basic Information Top
Gene Symbol:TIMP1 ( CLGI,EPA,EPO,FLJ90373,HCI,TIMP )
Gene Full Name: TIMP metallopeptidase inhibitor 1
Band: Xp11.3
Quick LinksEntrez ID:7076; OMIM: 305370; Uniprot ID:TIMP1_HUMAN; ENSEMBL ID: ENSG00000102265; HGNC ID: 11820
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576NAS-extracellular region1653055
GO:0005576TAS-extracellular region-
GO:0005578IBA-proteinaceous extracellular matrix-
GO:0005604IEA-basement membrane-
GO:0005615IDA-extracellular space3903517
GO:0005788TAS-endoplasmic reticulum lumen-
GO:0031093TAS-platelet alpha granule lumen-
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0002020IBA-protease binding-
GO:0005125IDA-cytokine activity3839290
GO:0005515IPI-protein binding2251898
GO:0008083IEA-growth factor activity-
GO:0008191IDA-metalloendopeptidase inhibitor activity3903517
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0001775IEA-cell activation-
GO:0002576TAS-platelet degranulation-
GO:0007568IEA-aging-
GO:0008284IDA-positive regulation of cell proliferation3839290
GO:0009725IBA-response to hormone-
GO:0010951IDA-negative regulation of endopeptidase activity3903517
GO:0022617TAS-extracellular matrix disassembly-
GO:0034097IBA-response to cytokine-
GO:0042060IEA-wound healing-
GO:0043066IEA-negative regulation of apoptotic process-
GO:0043086IDA-negative regulation of catalytic activity3903517
GO:0043434IEA-response to peptide hormone-
GO:0043687TAS-post-translational protein modification-
GO:0044267TAS-cellular protein metabolic process-
GO:0051045IDA-negative regulation of membrane protein ectodomain proteolysis12714508
GO:0051216IEA-cartilage development-
GO:1901164IMP-negative regulation of trophoblast cell migration21356369
GO:1905049IDA-negative regulation of metallopeptidase activity9573338
GO:2001044IMP-regulation of integrin-mediated signaling pathway16917503
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TIMP1ECH110822016169070 Two-hybrid
TIMP1ECH111293216169070 Two-hybrid
TIMP1EEF1B210825316169070 Two-hybrid
TIMP1EEF1B211293216169070 Two-hybrid
TIMP1MMP11129329063449 Reconstituted Complex
TIMP1MMP11104569063449 Reconstituted Complex
TIMP1MMP31129329288970 Co-crystal Structure
TIMP1MMP31104589288970 Co-crystal Structure
RECQL5TIMP111479716169070 Two-hybrid
RECQL5TIMP111293216169070 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
TIMP1rs1043945, rs723556 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:98752
  • Data Attributes: MGI curated and HomoloGene calculated
No data