AutismKB 2.0

Annotation Details for TLE1


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Basic Information Top
Gene Symbol:TLE1 ( ESG,ESG1,GRG1 )
Gene Full Name: transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
Band: 9q21.32
Quick LinksEntrez ID:7088; OMIM: 600189; Uniprot ID:TLE1_HUMAN; ENSEMBL ID: ENSG00000196781; HGNC ID: 11837
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus10748198
GO:0005634IMP-nucleus22952044
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005829IMP-cytosol22952044
GO ID Evidence Qualifier GO_term References
GO:0001106IDA-RNA polymerase II transcription corepressor activity10748198
GO:0005515IPI-protein binding9751710
GO:0008134IDA-transcription factor binding9751710
GO:0008134IPI-transcription factor binding8687460
GO:0042802IPI-identical protein binding24596249
GO ID Evidence Qualifier GO_term References
GO:0000122IEA-negative regulation of transcription from RNA polymerase II promoter-
GO:0006351IEA-transcription, DNA-templated-
GO:0007165TAS-signal transduction8808280
GO:0007275TAS-multicellular organism development8365415
GO:0009887TAS-animal organ morphogenesis8808280
GO:0010628IMP-positive regulation of gene expression15006356
GO:0016055IEA-Wnt signaling pathway-
GO:0030178NAS-negative regulation of Wnt signaling pathway9751710
GO:0043124IDA-negative regulation of I-kappaB kinase/NF-kappaB signaling17680780
GO:0045892IDA-negative regulation of transcription, DNA-templated9751710
GO:1904837TAS-beta-catenin-TCF complex assembly-
GO:2000811IMP-negative regulation of anoikis15006356
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TLE1AES11294317353931 Affinity Capture-MS
TLE1AES10667517353931 Affinity Capture-MS
TLE1ARL4D11294316169070 Two-hybrid
TLE1ARL4D10687416169070 Two-hybrid
TLE1ARL310689616169070 Two-hybrid
TLE1ARL311294316169070 Two-hybrid
TLE1PRDM11129439887105 Reconstituted Complex
TLE1PRDM11071089887105 Reconstituted Complex
TLE1RUNX211294320160071 Affinity Capture-Western; Co-localization
TLE1RUNX210730820160071 Affinity Capture-Western; Co-localization
TLE1RUNX11129439751710 Far Western; Two-hybrid
TLE1RUNX11073099751710 Far Western; Two-hybrid
TLE1RUNX31129439751710 Far Western; Two-hybrid
TLE1RUNX31073129751710 Far Western; Two-hybrid
TLE1CDKN2C10746516169070 Two-hybrid
TLE1CDKN2C11294316169070 Two-hybrid
TLE1NKX2-511294320211142 Two-hybrid
TLE1NKX2-510786420211142 Two-hybrid
TLE1CTNNB11129439751710 Reconstituted Complex
TLE1CTNNB11078809751710 Reconstituted Complex
TLE1ATN110815616169070 Two-hybrid
TLE1ATN111294316169070 Two-hybrid
TLE1EN111294316571670 Affinity Capture-Western
TLE1EN110833416571670 Affinity Capture-Western
TLE1ERH10839016169070 Two-hybrid
TLE1ERH11294316169070 Two-hybrid
TLE1GSTM410920316169070 Two-hybrid
TLE1GSTM411294316169070 Two-hybrid
TLE1HDAC110931519101520 Affinity Capture-Western; Reconstituted Complex
TLE1HDAC111294319101520 Affinity Capture-Western; Reconstituted Complex
TLE1HLA-DQA110936216169070 Two-hybrid
TLE1HLA-DQA111294316169070 Two-hybrid
TLE1HMGB111294311748221 Reconstituted Complex
TLE1HMGB110938911748221 Reconstituted Complex
TLE1FOXA110941120211142 Two-hybrid
TLE1FOXA111294320211142 Two-hybrid
TLE1FOXA210941210748198 Reconstituted Complex; Two-hybrid
TLE1FOXA211294310748198 Reconstituted Complex; Two-hybrid
TLE1FOXA310941320211142 Two-hybrid
TLE1FOXA311294320211142 Two-hybrid
TLE1TLX210943620211142 Two-hybrid
TLE1TLX211294320211142 Two-hybrid
TLE1HSPE110956816169070 Two-hybrid
TLE1HSPE111294316169070 Two-hybrid
TLE1IL6ST11294312030375 Affinity Capture-Western; Two-hybrid
TLE1IL6ST10978612030375 Affinity Capture-Western; Two-hybrid
TLE1MSX211294320211142 Two-hybrid
TLE1MSX211059420211142 Two-hybrid
TLE1SIX611103412441302 Reconstituted Complex; Two-hybrid
TLE1SIX611294312441302 Reconstituted Complex; Two-hybrid
TLE1PAFAH1B311294316169070 Two-hybrid
TLE1PAFAH1B311108716169070 Two-hybrid
TLE1PAX911111720211142 Two-hybrid
TLE1PAX911294320211142 Two-hybrid
TLE1PFN111123716169070 Two-hybrid
TLE1PFN111294316169070 Two-hybrid
TLE1SERPINB911294316169070 Two-hybrid
TLE1SERPINB911129016169070 Two-hybrid
TLE1POLB11141916169070 Two-hybrid
TLE1POLB11294316169070 Two-hybrid
TLE1POLE211142316169070 Two-hybrid
TLE1POLE211294316169070 Two-hybrid
TLE1PSMD1111168916169070 Two-hybrid
TLE1PSMD1111294316169070 Two-hybrid
TLE1PEX211294316169070 Two-hybrid
TLE1PEX211178616169070 Two-hybrid
TLE1RELA11294310660609 Affinity Capture-Western
TLE1RELA11190210660609 Affinity Capture-Western
TLE1RPA211203816169070 Two-hybrid
TLE1RPA211294316169070 Two-hybrid
TLE1SAT111294316169070 Two-hybrid
TLE1SAT111221016169070 Two-hybrid
TLE1CCL1811226516169070 Two-hybrid
TLE1CCL1811294316169070 Two-hybrid
TLE1SIX311294312441302 Reconstituted Complex; Two-hybrid
TLE1SIX311238712441302 Reconstituted Complex; Two-hybrid
TLE1SNRPG11252116169070 Two-hybrid
TLE1SNRPG11294316169070 Two-hybrid
TLE1TK111294316169070 Two-hybrid
TLE1TK111293816169070 Two-hybrid
LEF1TLE11193549751710 Reconstituted Complex
LEF1TLE11129439751710 Reconstituted Complex
UTYTLE11129439854018 Reconstituted Complex; Two-hybrid
UTYTLE11132479854018 Reconstituted Complex; Two-hybrid
KDM6ATLE11129439854018 Two-hybrid
KDM6ATLE11132469854018 Two-hybrid
TLE1TLE11129439874198 Reconstituted Complex; Two-hybrid
TLE2TLE11129439874198 Reconstituted Complex; Two-hybrid
TLE2TLE11129449874198 Reconstituted Complex; Two-hybrid
HES6TLE111294311551980 Affinity Capture-Western; Two-hybrid
HES6TLE112068211551980 Affinity Capture-Western; Two-hybrid
MPHOSPH6TLE111294316169070 Two-hybrid
MPHOSPH6TLE111549516169070 Two-hybrid
DLEU1TLE111294316169070 Two-hybrid
DLEU1TLE111558916169070 Two-hybrid
CELF3TLE111635916169070 Two-hybrid
CELF3TLE111294316169070 Two-hybrid
FXYD6TLE111294316169070 Two-hybrid
FXYD6TLE111979916169070 Two-hybrid
CRCT1TLE111294316169070 Two-hybrid
CRCT1TLE112003116169070 Two-hybrid
BTBD2TLE111294316169070 Two-hybrid
BTBD2TLE112077816169070 Two-hybrid
ZFP64TLE111294316169070 Two-hybrid
ZFP64TLE112085316169070 Two-hybrid
PCDHA4TLE111294316169070 Two-hybrid
PCDHA4TLE112108416169070 Two-hybrid
FUBP1TLE111294316169070 Two-hybrid
FUBP1TLE111439916169070 Two-hybrid
EIF2S2TLE111441116169070 Two-hybrid
EIF2S2TLE111294316169070 Two-hybrid
RNF10TLE111294316169070 Two-hybrid
RNF10TLE111524916169070 Two-hybrid
CUL4BTLE111402817041588 Affinity Capture-MS
CUL4BTLE111294317041588 Affinity Capture-MS
SIRT1TLE111294317680780 Affinity Capture-Western; Two-hybrid
SIRT1TLE111698317680780 Affinity Capture-Western; Two-hybrid
UBTFTLE111319020160071 Affinity Capture-Western
UBTFTLE111294320160071 Affinity Capture-Western
VENTXTLE111294320211142 Two-hybrid
VENTXTLE111811120211142 Two-hybrid
TLX3TLE111294320211142 Two-hybrid
TLX3TLE111903020211142 Two-hybrid
BARHL1TLE111294320211142 Two-hybrid
BARHL1TLE112119520211142 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:104636
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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