AutismKB 2.0

Annotation Details for TLR3


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Basic Information Top
Gene Symbol:TLR3 ( CD283 )
Gene Full Name: toll-like receptor 3
Band: 4q35.1
Quick LinksEntrez ID:7098; OMIM: 603029; Uniprot ID:TLR3_HUMAN; ENSEMBL ID: ENSG00000164342; HGNC ID: 11849
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139TAS-Golgi membrane-
GO:0005622IDA-intracellular25204797
GO:0005737IDA-cytoplasm19740627
GO:0005765IDA-lysosomal membrane17897319
GO:0005769IEA-early endosome-
GO:0005789TAS-endoplasmic reticulum membrane-
GO:0005887TAS-integral component of plasma membrane9435236
GO:0009986IDANOTcell surface19740627
GO:0010008TAS-endosome membrane-
GO:0016020NAS-membrane12054664
GO:0036020TAS-endolysosome membrane-
GO ID Evidence Qualifier GO_term References
GO:0003725IDA-double-stranded RNA binding16111635
GO:0003725NAS-double-stranded RNA binding12054664
GO:0004872TAS-receptor activity10426995
GO:0004888NAS-transmembrane signaling receptor activity12054664
GO:0005515IPI-protein binding16858407
GO:0042802IPI-identical protein binding25217833
GO ID Evidence Qualifier GO_term References
GO:0002224TAS-toll-like receptor signaling pathway-
GO:0002282IEA-microglial cell activation involved in immune response-
GO:0002730IEA-regulation of dendritic cell cytokine production-
GO:0002756TAS-MyD88-independent toll-like receptor signaling pathway-
GO:0006954IEA-inflammatory response-
GO:0006972NAS-hyperosmotic response12054664
GO:0007165TAS-signal transduction9435236
GO:0007249TAS-I-kappaB kinase/NF-kappaB signaling-
GO:0007250NAS-activation of NF-kappaB-inducing kinase activity12054664
GO:0007252IDA-I-kappaB phosphorylation19740627
GO:0008584IEA-male gonad development-
GO:0009597NAS-detection of virus12054664
GO:0010628IMP-positive regulation of gene expression23817958
GO:0032722IDA-positive regulation of chemokine production19740627
GO:0032728ISS-positive regulation of interferon-beta production-
GO:0032735ISS-positive regulation of interleukin-12 production-
GO:0032755IDA-positive regulation of interleukin-6 production19740627
GO:0032757IDA-positive regulation of interleukin-8 production17128265
GO:0032760ISS-positive regulation of tumor necrosis factor production-
GO:0034123IDA-positive regulation of toll-like receptor signaling pathway17128265
GO:0034128TAS-negative regulation of MyD88-independent toll-like receptor signaling pathway-
GO:0034138TAS-toll-like receptor 3 signaling pathway-
GO:0034346IEA-positive regulation of type III interferon production-
GO:0035458IEA-cellular response to interferon-beta-
GO:0035666TAS-TRIF-dependent toll-like receptor signaling pathway-
GO:0035690IEA-cellular response to drug-
GO:0042346IDA-positive regulation of NF-kappaB import into nucleus19740627
GO:0042742TAS-defense response to bacterium10426995
GO:0043065IEA-positive regulation of apoptotic process-
GO:0043330IDA-response to exogenous dsRNA21266579
GO:0045078IDA-positive regulation of interferon-gamma biosynthetic process16286015
GO:0045080IEA-positive regulation of chemokine biosynthetic process-
GO:0045087TAS-innate immune response15356140
GO:0045356IDA-positive regulation of interferon-alpha biosynthetic process16286015
GO:0045359IDA-positive regulation of interferon-beta biosynthetic process16286015
GO:0045359IMP-positive regulation of interferon-beta biosynthetic process12054664
GO:0045671NAS-negative regulation of osteoclast differentiation12133979
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0046330IEA-positive regulation of JNK cascade-
GO:0050729IC-positive regulation of inflammatory response19740627
GO:0051092IEA-positive regulation of NF-kappaB transcription factor activity-
GO:0051607TAS-defense response to virus15356140
GO:0070266TAS-necroptotic process-
GO:0071260IEP-cellular response to mechanical stimulus19593445
GO:0071346IEA-cellular response to interferon-gamma-
GO:0071360IEA-cellular response to exogenous dsRNA-
GO:0097190TAS-apoptotic signaling pathway-
GO:0097191IDA-extrinsic apoptotic signaling pathway21737330
GO:0097527IDA-necroptotic signaling pathway21737330
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TLR3IRAK211295317878161 Affinity Capture-Western
TLR3IRAK210986517878161 Affinity Capture-Western
TLR3MYD8811295312646618 Reconstituted Complex
TLR3MYD8811070012646618 Reconstituted Complex
RNF216TLR311295315107846 Two-hybrid
RNF216TLR311998115107846 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2156367
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040219-7'