AutismKB 2.0

Annotation Details for TLR4


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Basic Information Top
Gene Symbol:TLR4 ( ARMD10,CD284,TOLL,hToll )
Gene Full Name: toll-like receptor 4
Band: 9q33.1
Quick LinksEntrez ID:7099; OMIM: 603030; Uniprot ID:TLR4_HUMAN; ENSEMBL ID: ENSG00000136869; HGNC ID: 11850
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm19740627
GO:0005886IDA-plasma membrane19740627
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane15027902
GO:0009897IDA-external side of plasma membrane16514062
GO:0009986IDA-cell surface25204797
GO:0010008TAS-endosome membrane-
GO:0031226IDA-intrinsic component of plasma membrane11274165
GO:0046696IDA-lipopolysaccharide receptor complex11274165
GO:0048471IDA-perinuclear region of cytoplasm15027902
GO ID Evidence Qualifier GO_term References
GO:0001530IMP-lipopolysaccharide binding16514062
GO:0001530NAS-lipopolysaccharide binding10835634
GO:0001875IDA-lipopolysaccharide receptor activity19252480
GO:0004872TAS-receptor activity10426995
GO:0004888NAS-transmembrane signaling receptor activity11970998
GO:0005515IPI-protein binding11441107
GO ID Evidence Qualifier GO_term References
GO:0000187ISS-activation of MAPK activity-
GO:0002224IBA-toll-like receptor signaling pathway-
GO:0002224TAS-toll-like receptor signaling pathway-
GO:0002322IEA-B cell proliferation involved in immune response-
GO:0002537IEA-nitric oxide production involved in inflammatory response-
GO:0002730IEA-regulation of dendritic cell cytokine production-
GO:0002755TAS-MyD88-dependent toll-like receptor signaling pathway-
GO:0002756TAS-MyD88-independent toll-like receptor signaling pathway-
GO:0006954IBA-inflammatory response-
GO:0006955TAS-immune response10426995
GO:0007249TAS-I-kappaB kinase/NF-kappaB signaling-
GO:0007252IDA-I-kappaB phosphorylation19740627
GO:0010572ISS-positive regulation of platelet activation16514062
GO:0010628IMP-positive regulation of gene expression23817958
GO:0014002IEA-astrocyte development-
GO:0016046NAS-detection of fungus11254600
GO:0030890IEA-positive regulation of B cell proliferation-
GO:0031663IDANOTlipopolysaccharide-mediated signaling pathway10880523
GO:0031663IGI-lipopolysaccharide-mediated signaling pathway10880523
GO:0032496IC-response to lipopolysaccharide16514062
GO:0032496IDA-response to lipopolysaccharide12594207
GO:0032497IDA-detection of lipopolysaccharide19252480
GO:0032609IEA-interferon-gamma production-
GO:0032689ISS-negative regulation of interferon-gamma production-
GO:0032700ISS-negative regulation of interleukin-17 production-
GO:0032707ISS-negative regulation of interleukin-23 production-
GO:0032715ISS-negative regulation of interleukin-6 production-
GO:0032720ISS-negative regulation of tumor necrosis factor production-
GO:0032722IDA-positive regulation of chemokine production19740627
GO:0032727ISS-positive regulation of interferon-alpha production-
GO:0032728ISS-positive regulation of interferon-beta production-
GO:0032729ISS-positive regulation of interferon-gamma production-
GO:0032732ISS-positive regulation of interleukin-1 production-
GO:0032733ISS-positive regulation of interleukin-10 production-
GO:0032735ISS-positive regulation of interleukin-12 production-
GO:0032755IDA-positive regulation of interleukin-6 production19740627
GO:0032757IDA-positive regulation of interleukin-8 production19740627
GO:0032760ISS-positive regulation of tumor necrosis factor production-
GO:0034128TAS-negative regulation of MyD88-independent toll-like receptor signaling pathway-
GO:0034142TAS-toll-like receptor 4 signaling pathway-
GO:0035666TAS-TRIF-dependent toll-like receptor signaling pathway-
GO:0042088NAS-T-helper 1 type immune response11970998
GO:0042116IMP-macrophage activation10835634
GO:0042346IDA-positive regulation of NF-kappaB import into nucleus19740627
GO:0042535IDA-positive regulation of tumor necrosis factor biosynthetic process17951129
GO:0042742TAS-defense response to bacterium10426995
GO:0045084IDA-positive regulation of interleukin-12 biosynthetic process15027902
GO:0045087TAS-innate immune response15356140
GO:0045348IEA-positive regulation of MHC class II biosynthetic process-
GO:0045359IEA-positive regulation of interferon-beta biosynthetic process-
GO:0045416IDA-positive regulation of interleukin-8 biosynthetic process17951129
GO:0045429IEA-positive regulation of nitric oxide biosynthetic process-
GO:0045671NAS-negative regulation of osteoclast differentiation12133979
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0046330IEA-positive regulation of JNK cascade-
GO:0050702ISS-interleukin-1 beta secretion-
GO:0050707IEA-regulation of cytokine secretion-
GO:0050729IC-positive regulation of inflammatory response19740627
GO:0050829IBA-defense response to Gram-negative bacterium-
GO:0050829IC-defense response to Gram-negative bacterium16514062
GO:0051092IDA-positive regulation of NF-kappaB transcription factor activity12594207
GO:0051770ISS-positive regulation of nitric-oxide synthase biosynthetic process-
GO:0060729ISS-intestinal epithelial structure maintenance-
GO:0060907IEA-positive regulation of macrophage cytokine production-
GO:0070266TAS-necroptotic process-
GO:0070373ISS-negative regulation of ERK1 and ERK2 cascade-
GO:0070374IEA-positive regulation of ERK1 and ERK2 cascade-
GO:0070430IEA-positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway-
GO:0070434IEA-positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway-
GO:0071222ISS-cellular response to lipopolysaccharide-
GO:0071223IEA-cellular response to lipoteichoic acid-
GO:0071260IEP-cellular response to mechanical stimulus19593445
GO:0097190TAS-apoptotic signaling pathway-
GO:1900227ISS-positive regulation of NLRP3 inflammasome complex assembly-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TLR4MYD8811295410952994 11544529 12646618 15107846 17258210 18221795 20048342 Affinity Capture-Western; PCA; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
TLR4MYD8811070010952994 11544529 12646618 15107846 17258210 18221795 20048342 Affinity Capture-Western; PCA; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
TLR4PPP4C11152318634786 Affinity Capture-Western
TLR4PPP4C11295418634786 Affinity Capture-Western
TLR4TLR111295111932926 Affinity Capture-Western
TLR4TLR111295411932926 Affinity Capture-Western
LY96TLR411717010359581 11976338 Affinity Capture-Western
LY96TLR411295410359581 11976338 Affinity Capture-Western
ECSITTLR411295410465784 Phenotypic Suppression
ECSITTLR411944610465784 Phenotypic Suppression
TIRAPTLR412532511526399 11544529 17258210 18221795 20048342 Affinity Capture-Western; PCA; Phenotypic Suppression; Reconstituted Complex
TIRAPTLR411295411526399 11544529 17258210 18221795 20048342 Affinity Capture-Western; PCA; Phenotypic Suppression; Reconstituted Complex
TOLLIPTLR411295411751856 Affinity Capture-Western; Reconstituted Complex
TOLLIPTLR411997811751856 Affinity Capture-Western; Reconstituted Complex
SIGIRRTLR411295412925853 Affinity Capture-Western
SIGIRRTLR412187312925853 Affinity Capture-Western
RNF216TLR411295415107846 Two-hybrid
RNF216TLR411998115107846 Two-hybrid
TICAM2TLR413169417258210 18221795 PCA
TICAM2TLR411295417258210 18221795 PCA
Gene Symbol Interactant Interaction ID References Description
LY96TLR419665510359581 MD-2 interacts with TLR4
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
TLR4rs4986790 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:96824
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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