AutismKB 2.0

Annotation Details for TNFAIP3


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Basic Information Top
Gene Symbol:TNFAIP3 ( A20,MGC104522,MGC138687,MGC138688,OTUD7C,TNFA1P2 )
Gene Full Name: tumor necrosis factor, alpha-induced protein 3
Band: 6q23.3
Quick LinksEntrez ID:7128; OMIM: 191163; Uniprot ID:TNAP3_HUMAN; ENSEMBL ID: ENSG00000118503; HGNC ID: 11896
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus11463333
GO:0005737IBA-cytoplasm-
GO:0005764IEA-lysosome-
GO:0005829TAS-cytosol-
GO:0070062IDA-extracellular exosome20458337
GO ID Evidence Qualifier GO_term References
GO:0002020IPI-protease binding18223652
GO:0003677IEA-DNA binding-
GO:0004842IDA-ubiquitin-protein transferase activity15258597
GO:0004843IDA-thiol-dependent ubiquitin-specific protease activity15258597
GO:0004843TAS-thiol-dependent ubiquitin-specific protease activity20392859
GO:0005515IPI-protein binding9299557
GO:0008270IEA-zinc ion binding-
GO:0016874IEA-ligase activity-
GO:0019900IEA-kinase binding-
GO:0042802IPI-identical protein binding25416956
GO:0043130IPI-ubiquitin binding19285159
GO:0043621IDA-protein self-association8797804
GO:0061578EXP-Lys63-specific deubiquitinase activity14748687
GO:0061578TAS-Lys63-specific deubiquitinase activity-
GO:0070530IBA-K63-linked polyubiquitin binding-
GO ID Evidence Qualifier GO_term References
GO:0001922ISS-B-1 B cell homeostasis-
GO:0002237IDA-response to molecule of bacterial origin19912257
GO:0002634ISS-regulation of germinal center formation-
GO:0002677IEA-negative regulation of chronic inflammatory response-
GO:0006915IEA-apoptotic process-
GO:0006954IEA-inflammatory response-
GO:0010803TAS-regulation of tumor necrosis factor-mediated signaling pathway-
GO:0016579TAS-protein deubiquitination20392859
GO:0031397IDA-negative regulation of protein ubiquitination20392859
GO:0032088IDA-negative regulation of NF-kappaB transcription factor activity18223652
GO:0032480TAS-negative regulation of type I interferon production-
GO:0032495IEA-response to muramyl dipeptide-
GO:0032691IEA-negative regulation of interleukin-1 beta production-
GO:0032703IMP-negative regulation of interleukin-2 production18223652
GO:0032715ISS-negative regulation of interleukin-6 production-
GO:0032720ISS-negative regulation of tumor necrosis factor production-
GO:0034136NAS-negative regulation of toll-like receptor 2 signaling pathway15142865
GO:0034140IDA-negative regulation of toll-like receptor 3 signaling pathway15474016
GO:0034144NAS-negative regulation of toll-like receptor 4 signaling pathway15142865
GO:0034148IEA-negative regulation of toll-like receptor 5 signaling pathway-
GO:0035871IDA-protein K11-linked deubiquitination23827681
GO:0043124IDA-negative regulation of I-kappaB kinase/NF-kappaB signaling11463333
GO:0045732IDA-positive regulation of protein catabolic process21127049
GO:0045736IEA-negative regulation of cyclin-dependent protein serine/threonine kinase activity-
GO:0045779NAS-negative regulation of bone resorption21127049
GO:0045824ISS-negative regulation of innate immune response-
GO:0048662IDA-negative regulation of smooth muscle cell proliferation16816117
GO:0050691NAS-regulation of defense response to virus by host15142865
GO:0050727IBA-regulation of inflammatory response-
GO:0050728ISS-negative regulation of inflammatory response-
GO:0050869ISS-negative regulation of B cell activation-
GO:0051259NAS-protein oligomerization15474016
GO:0061043NAS-regulation of vascular wound healing16816117
GO:0070301ISS-cellular response to hydrogen peroxide-
GO:0070423TAS-nucleotide-binding oligomerization domain containing signaling pathway-
GO:0070429IEA-negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway-
GO:0070433IEA-negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway-
GO:0070536IDA-protein K63-linked deubiquitination15258597
GO:0070936IDA-protein K48-linked ubiquitination15258597
GO:0071108IDA-protein K48-linked deubiquitination23827681
GO:0071222IDA-cellular response to lipopolysaccharide19912257
GO:0071947IBA-protein deubiquitination involved in ubiquitin-dependent protein catabolic process-
GO:0072573IMP-tolerance induction to lipopolysaccharide21220427
GO:0072666IEA-establishment of protein localization to vacuole-
GO:0090291NAS-negative regulation of osteoclast proliferation21127049
GO:1902042IDA-negative regulation of extrinsic apoptotic signaling pathway via death domain receptors12167698
GO:1903364IEA-positive regulation of cellular protein catabolic process-
GO:2000347IEA-positive regulation of hepatocyte proliferation-
GO:2000349IMP-negative regulation of CD40 signaling pathway12885753
GO:2000352IDA-negative regulation of endothelial cell apoptotic process12885753
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TNFAIP3ALDH9A110672519615732 Affinity Capture-MS
TNFAIP3ALDH9A111298319615732 Affinity Capture-MS
TNFAIP3CASP810729119060883 Affinity Capture-Western
TNFAIP3CASP811298319060883 Affinity Capture-Western
TNFAIP3CHUK10756911594795 Affinity Capture-Western
TNFAIP3CHUK11298311594795 Affinity Capture-Western
TNFAIP3GLDC10899319615732 Affinity Capture-MS
TNFAIP3GLDC11298319615732 Affinity Capture-MS
TNFAIP3IKBKB10976711594795 Biochemical Activity
TNFAIP3IKBKB11298311594795 Biochemical Activity
TNFAIP3KIF1111003019615732 Affinity Capture-MS
TNFAIP3KIF1111298319615732 Affinity Capture-MS
TNFAIP3LAMP111011018329387 Co-fractionation
TNFAIP3LAMP111298318329387 Co-fractionation
TNFAIP3MCM611034319615732 Affinity Capture-MS
TNFAIP3MCM611298319615732 Affinity Capture-MS
TNFAIP3NDUFS111079919615732 Affinity Capture-MS
TNFAIP3NDUFS111298319615732 Affinity Capture-MS
TNFAIP3PPP2R1B11151119615732 Affinity Capture-MS
TNFAIP3PPP2R1B11298319615732 Affinity Capture-MS
TNFAIP3RARRES311185516306043 Affinity Capture-Western
TNFAIP3RARRES311298316306043 Affinity Capture-Western
TNFAIP3RNH111197719615732 Affinity Capture-MS
TNFAIP3RNH111298319615732 Affinity Capture-MS
TRAF1TNFAIP31130378692885 9928991 Affinity Capture-Western; Two-hybrid
TRAF1TNFAIP31129838692885 9928991 Affinity Capture-Western; Two-hybrid
TRAF2TNFAIP31130388692885 Affinity Capture-Western; Two-hybrid
TRAF2TNFAIP31129838692885 Affinity Capture-Western; Two-hybrid
TNFAIP3TNFAIP31129838692885 Two-hybrid
YWHABTNFAIP31133618702721 19615732 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHABTNFAIP31129838702721 19615732 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHAHTNFAIP31133658702721 9299557 19615732 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHAHTNFAIP31129838702721 9299557 19615732 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHAETNFAIP31133638702721 Affinity Capture-Western
YWHAETNFAIP31129838702721 Affinity Capture-Western
YWHAZTNFAIP31133668702721 9299557 20936779 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHAZTNFAIP31129838702721 9299557 20936779 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TRAF6TNFAIP31130419928991 11463333 18164316 Affinity Capture-Western
TRAF6TNFAIP31129839928991 11463333 18164316 Affinity Capture-Western
TNIP1TNFAIP311298310385526 Affinity Capture-Western; Two-hybrid
TNIP1TNFAIP311560210385526 Affinity Capture-Western; Two-hybrid
TAX1BP1TNFAIP311298310435631 Affinity Capture-Western; Two-hybrid
TAX1BP1TNFAIP311440510435631 Affinity Capture-Western; Two-hybrid
IKBKGTNFAIP311298310755617 Affinity Capture-Western; Two-hybrid
IKBKGTNFAIP311408910755617 Affinity Capture-Western; Two-hybrid
RIPK1TNFAIP311298315258597 19131965 Affinity Capture-Western; Biochemical Activity
RIPK1TNFAIP311427415258597 19131965 Affinity Capture-Western; Biochemical Activity
RNF11TNFAIP311298319131965 Affinity Capture-Western
RNF11TNFAIP311794119131965 Affinity Capture-Western
CNKSR2TNFAIP311298319615732 Affinity Capture-MS
CNKSR2TNFAIP311653419615732 Affinity Capture-MS
FBXO3TNFAIP311298319615732 Affinity Capture-MS
FBXO3TNFAIP311765719615732 Affinity Capture-MS
TBK1TNFAIP311298319615732 Affinity Capture-MS
TBK1TNFAIP311887819615732 Affinity Capture-MS
PPP6R3TNFAIP311298319615732 Affinity Capture-MS
PPP6R3TNFAIP312057919615732 Affinity Capture-MS
LRRC47TNFAIP311298319615732 Affinity Capture-MS
LRRC47TNFAIP312154019615732 Affinity Capture-MS
YWHAGTNFAIP311336420936779 Two-hybrid
YWHAGTNFAIP311298320936779 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1196377
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-100212-2'