AutismKB 2.0

Annotation Details for TNFRSF1A


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Basic Information Top
Gene Symbol:TNFRSF1A ( CD120a,FPF,MGC19588,TBP1,TNF-R,TNF-R-I,TNF-R55,TNFAR,TNFR1,TNFR55,TNFR60,p55,p55-R,p60 )
Gene Full Name: tumor necrosis factor receptor superfamily, member 1A
Band: 12p13.31
Quick LinksEntrez ID:7132; OMIM: 191190; Uniprot ID:TNR1A_HUMAN; ENSEMBL ID: ENSG00000067182; HGNC ID: 11916
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139IDA-Golgi membrane22801493
GO:0005576NAS-extracellular region12189246
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space13130484
GO:0005739IBA-mitochondrion-
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane1698610
GO:0009986IEA-cell surface-
GO:0043235IDA-receptor complex23382219
GO:0045121IDA-membrane raft17010968
GO ID Evidence Qualifier GO_term References
GO:0005031TAS-tumor necrosis factor-activated receptor activity2158863
GO:0005515IPI-protein binding1087798
GO:0043120IBA-tumor necrosis factor binding-
GO ID Evidence Qualifier GO_term References
GO:0006693IEA-prostaglandin metabolic process-
GO:0006954ISS-inflammatory response-
GO:0006955IBA-immune response-
GO:0007249TAS-I-kappaB kinase/NF-kappaB signaling-
GO:0008625TAS-extrinsic apoptotic signaling pathway via death domain receptors8612133
GO:0008630IEA-intrinsic apoptotic signaling pathway in response to DNA damage-
GO:0010803TAS-regulation of tumor necrosis factor-mediated signaling pathway-
GO:0016032IEA-viral process-
GO:0019221ISS-cytokine-mediated signaling pathway-
GO:0032496IBA-response to lipopolysaccharide-
GO:0033209IMP-tumor necrosis factor-mediated signaling pathway25816133
GO:0033209TAS-tumor necrosis factor-mediated signaling pathway-
GO:0042127IBA-regulation of cell proliferation-
GO:0042531IMP-positive regulation of tyrosine phosphorylation of STAT protein21410936
GO:0042742IEA-defense response to bacterium-
GO:0042981IBA-regulation of apoptotic process-
GO:0043123IEP-positive regulation of I-kappaB kinase/NF-kappaB signaling12761501
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter21410936
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0050728IMP-negative regulation of inflammatory response13130484
GO:0050729ISS-positive regulation of inflammatory response-
GO:0071260IEP-cellular response to mechanical stimulus19593445
GO:0071550TAS-death-inducing signaling complex assembly-
GO:0090002IMP-establishment of protein localization to plasma membrane25816133
GO:1903140IMP-regulation of establishment of endothelial barrier25816133
GO:2000304TAS-positive regulation of ceramide biosynthetic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TNFRSF1ABIRC21129868943045 Affinity Capture-Western
TNFRSF1ABIRC21068268943045 Affinity Capture-Western
TNFRSF1ABIRC311298618939944 Affinity Capture-Western
TNFRSF1ABIRC310682718939944 Affinity Capture-Western
TNFRSF1AFAS10685115659383 Co-purification
TNFRSF1AFAS11298615659383 Co-purification
TNFRSF1AFASLG11298612753742 15659383 Affinity Capture-Western; Co-purification
TNFRSF1AFASLG10685212753742 15659383 Affinity Capture-Western; Co-purification
TNFRSF1ARHOA11298615659383 Co-purification
TNFRSF1ARHOA10688015659383 Co-purification
TNFRSF1AARHGDIA10688915659383 Co-purification
TNFRSF1AARHGDIA11298615659383 Co-purification
TNFRSF1ABID11298615659383 Co-purification
TNFRSF1ABID10710615659383 Co-purification
TNFRSF1ACASP21072858985253 Affinity Capture-Western
TNFRSF1ACASP21129868985253 Affinity Capture-Western
TNFRSF1ACASP711298611755217 Biochemical Activity
TNFRSF1ACASP710729011755217 Biochemical Activity
TNFRSF1ACASP811298615659383 Co-purification
TNFRSF1ACASP810729115659383 Co-purification
TNFRSF1ACASP101129869045686 15659383 Affinity Capture-Western; Co-purification
TNFRSF1ACASP101072939045686 15659383 Affinity Capture-Western; Co-purification
TNFRSF1ACAV110730512753742 Co-fractionation
TNFRSF1ACAV111298612753742 Co-fractionation
TNFRSF1ADAPK111298612911633 Affinity Capture-Western
TNFRSF1ADAPK110798212911633 Affinity Capture-Western
TNFRSF1AFANCD211298614743216 Affinity Capture-MS
TNFRSF1AFANCD210847414743216 Affinity Capture-MS
TNFRSF1AFYN10881012753742 Co-fractionation
TNFRSF1AFYN11298612753742 Co-fractionation
TNFRSF1AGRB210914210359574 Affinity Capture-Western
TNFRSF1AGRB211298610359574 Affinity Capture-Western
TNFRSF1AHSPA811298611909948 Reconstituted Complex
TNFRSF1AHSPA810954411909948 Reconstituted Complex
TNFRSF1AIKBKB10976710755617 11002417 Affinity Capture-Western; Biochemical Activity
TNFRSF1AIKBKB11298610755617 11002417 Affinity Capture-Western; Biochemical Activity
TNFRSF1AJAK11129869510175 11801527 Affinity Capture-Western; Reconstituted Complex
TNFRSF1AJAK11099199510175 11801527 Affinity Capture-Western; Reconstituted Complex
TNFRSF1AJAK21129869510175 Affinity Capture-Western; Reconstituted Complex
TNFRSF1AJAK21099209510175 Affinity Capture-Western; Reconstituted Complex
TNFRSF1ALTA1129868387891 Co-crystal Structure
TNFRSF1ALTA1102278387891 Co-crystal Structure
TNFRSF1ALTB1129867995952 Reconstituted Complex
TNFRSF1ALTB1102287995952 Reconstituted Complex
TNFRSF1AMSN11298615659383 Co-purification
TNFRSF1AMSN11058415659383 Co-purification
TNFRSF1AMAPK811298615659383 Co-purification
TNFRSF1AMAPK811158515659383 Co-purification
TNFRSF1APSMD21129867601280 9126987 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TNFRSF1APSMD21116817601280 9126987 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TNFRSF1ASTAT111298610848577 Affinity Capture-Western
TNFRSF1ASTAT111264910848577 Affinity Capture-Western
TNFRSF1ATNF11298612753742 12887920 14743216 15485837 Affinity Capture-MS; Affinity Capture-Western
TNFRSF1ATNF11297912753742 12887920 14743216 15485837 Affinity Capture-MS; Affinity Capture-Western
TRAP1TNFRSF1A1154357876093 Reconstituted Complex
TRAP1TNFRSF1A1129867876093 Reconstituted Complex
TNFRSF1ATNFRSF1A1129868077196 10875917 Affinity Capture-Western; FRET; Two-hybrid
TRAF1TNFRSF1A1129868565075 Affinity Capture-Western
TRAF1TNFRSF1A1130378565075 Affinity Capture-Western
TRAF2TNFRSF1A1129868565075 8612133 8943045 Affinity Capture-Western
TRAF2TNFRSF1A1130388565075 8612133 8943045 Affinity Capture-Western
FADDTNFRSF1A1129868565075 15659383 Affinity Capture-Western; Co-purification
FADDTNFRSF1A1143028565075 15659383 Affinity Capture-Western; Co-purification
TRADDTNFRSF1A1129868565075 8612133 8943045 9082980 9915703 10187805 18939944 Affinity Capture-Western; Two-hybrid
TRADDTNFRSF1A1142578565075 8612133 8943045 9082980 9915703 10187805 18939944 Affinity Capture-Western; Two-hybrid
RIPK1TNFRSF1A1142748612133 8985253 11002422 16968706 18621737 18724939 18939944 Affinity Capture-Western
RIPK1TNFRSF1A1129868612133 8985253 11002422 16968706 18621737 18724939 18939944 Affinity Capture-Western
NSMAFTNFRSF1A1140198808629 Affinity Capture-Western; Two-hybrid
NSMAFTNFRSF1A1129868808629 Affinity Capture-Western; Two-hybrid
SUMO1TNFRSF1A1129868906799 10187798 Reconstituted Complex; Two-hybrid
SUMO1TNFRSF1A1131888906799 10187798 Reconstituted Complex; Two-hybrid
CRADDTNFRSF1A1142758985253 Affinity Capture-Western
CRADDTNFRSF1A1129868985253 Affinity Capture-Western
PIP4K2BTNFRSF1A1129869038203 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PIP4K2BTNFRSF1A1139859038203 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MADDTNFRSF1A1129869115275 Reconstituted Complex
MADDTNFRSF1A1141369115275 Reconstituted Complex
NOL3TNFRSF1A1129869560245 Phenotypic Suppression
NOL3TNFRSF1A1144779560245 Phenotypic Suppression
UBE2ITNFRSF1A1131779563508 Reconstituted Complex; Two-hybrid
UBE2ITNFRSF1A1129869563508 Reconstituted Complex; Two-hybrid
RIPK2TNFRSF1A1129869642260 Affinity Capture-Western
RIPK2TNFRSF1A1143009642260 Affinity Capture-Western
BAG4TNFRSF1A1129869915703 11909948 Affinity Capture-Western; Reconstituted Complex
BAG4TNFRSF1A1149069915703 11909948 Affinity Capture-Western; Reconstituted Complex
CEP110TNFRSF1A11624810187805 Affinity Capture-Western
CEP110TNFRSF1A11298610187805 Affinity Capture-Western
RIPK3TNFRSF1A11622410339433 Affinity Capture-Western
RIPK3TNFRSF1A11298610339433 Affinity Capture-Western
BCL10TNFRSF1A11298610400625 Two-hybrid
BCL10TNFRSF1A11442910400625 Two-hybrid
TNFSF13TNFRSF1A11427810706119 Reconstituted Complex
TNFSF13TNFRSF1A11298610706119 Reconstituted Complex
IKBKGTNFRSF1A11298610755617 Affinity Capture-Western
IKBKGTNFRSF1A11408910755617 Affinity Capture-Western
UBCTNFRSF1A11298612753742 Affinity Capture-Western
UBCTNFRSF1A11316412753742 Affinity Capture-Western
TRPC4APTNFRSF1A11298614585990 Affinity Capture-Western; Reconstituted Complex
TRPC4APTNFRSF1A11756914585990 Affinity Capture-Western; Reconstituted Complex
BRETNFRSF1A11494615465831 Affinity Capture-Western
BRETNFRSF1A11298615465831 Affinity Capture-Western
EZRTNFRSF1A11298615659383 Co-purification
EZRTNFRSF1A11327115659383 Co-purification
TNFRSF10BTNFRSF1A11298615659383 Co-purification
TNFRSF10BTNFRSF1A11432315659383 Co-purification
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
TNFRSF1Ars4149569, rs4149570, rs767455 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
TNFRSF1Ars4149570, rs767455 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:1314884
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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