AutismKB 2.0

Annotation Details for TOP1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TOP1 ( TOPI )
Gene Full Name: topoisomerase (DNA) I
Band: 20q12
Quick LinksEntrez ID:7150; OMIM: 126420; Uniprot ID:TOP1_HUMAN; ENSEMBL ID: ENSG00000198900; HGNC ID: 11986
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000228IDAcolocalizes_withnuclear chromosome9049244
GO:0000932IDA-P-body12878161
GO:0001650IDA-fibrillar center-
GO:0005634IDA-nucleus9049244
GO:0005654IDA-nucleoplasm9049244
GO:0005654IMP-nucleoplasm14654701
GO:0005654TAS-nucleoplasm-
GO:0005730IDA-nucleolus9049244
GO:0005730IMP-nucleolus14654701
GO:0009330IMP-DNA topoisomerase complex (ATP-hydrolyzing)8567649
GO:0031298IBA-replication fork protection complex-
GO:0032993IMP-protein-DNA complex10497031
GO:0043204IEA-perikaryon-
GO ID Evidence Qualifier GO_term References
GO:0001046IDA-core promoter sequence-specific DNA binding22904072
GO:0003677IDA-DNA binding17355975
GO:0003677IMP-DNA binding10497031
GO:0003682IDA-chromatin binding9049244
GO:0003690IMP-double-stranded DNA binding8631794
GO:0003697IMP-single-stranded DNA binding8631794
GO:0003723IDA-RNA binding22658674
GO:0003917IDA-DNA topoisomerase type I activity14594810
GO:0003917IMP-DNA topoisomerase type I activity8567649
GO:0004674IMP-protein serine/threonine kinase activity9611241
GO:0005515IPI-protein binding8567649
GO:0005524IMP-ATP binding8631793
GO:0019904IPI-protein domain specific binding9611241
GO:0097100IMP-supercoiled DNA binding8631793
GO ID Evidence Qualifier GO_term References
GO:0006260IBA-DNA replication-
GO:0006265IDA-DNA topological change14594810
GO:0006265IMP-DNA topological change8567649
GO:0006338IMP-chromatin remodeling22904072
GO:0007059IBA-chromosome segregation-
GO:0007623IEP-circadian rhythm22904072
GO:0012501NAS-programmed cell death17172417
GO:0016032IEA-viral process-
GO:0016310NAS-phosphorylation17481653
GO:0016925TAS-protein sumoylation-
GO:0018105IMP-peptidyl-serine phosphorylation9611241
GO:0032922IMP-circadian regulation of gene expression22904072
GO:0040016IEA-embryonic cleavage-
GO:0042493IEP-response to drug16127745
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TOP1CDKN2A11300315361825 Affinity Capture-Western
TOP1CDKN2A10746315361825 Affinity Capture-Western
TOP1CSNK2A11078412998765 Biochemical Activity
TOP1CSNK2A11130032998765 Biochemical Activity
TOP1CSNK2A21078422998765 Biochemical Activity
TOP1CSNK2A21130032998765 Biochemical Activity
TOP1MGMT11041116226712 Affinity Capture-MS
TOP1MGMT11300316226712 Affinity Capture-MS
TOP1NCL1130038567649 9512561 Affinity Capture-Western; Reconstituted Complex
TOP1NCL1107718567649 9512561 Affinity Capture-Western; Reconstituted Complex
TOP1PMS111300317148452 Affinity Capture-Western
TOP1PMS111139117148452 Affinity Capture-Western
TOP1SFPQ1130039756848 Affinity Capture-Western
TOP1SFPQ1123199756848 Affinity Capture-Western
TOP1SRSF11130039611241 12270705 Far Western; Reconstituted Complex
TOP1SRSF11123249611241 12270705 Far Western; Reconstituted Complex
TOP1TAL111274916407974 Affinity Capture-MS
TOP1TAL111300316407974 Affinity Capture-MS
SRSF11TOP11130039756848 Affinity Capture-Western
SRSF11TOP11147099756848 Affinity Capture-Western
TOPORSTOP111300310352183 Affinity Capture-Western; Two-hybrid
TOPORSTOP111550510352183 Affinity Capture-Western; Two-hybrid
TP53TOP111300310468612 11805286 Affinity Capture-Western; Two-hybrid
TP53TOP111301010468612 11805286 Affinity Capture-Western; Two-hybrid
UBE2ITOP111317710759568 Reconstituted Complex; Two-hybrid
UBE2ITOP111300310759568 Reconstituted Complex; Two-hybrid
SUMO1TOP111300311709553 Biochemical Activity
SUMO1TOP111318811709553 Biochemical Activity
BTBD1TOP111300311818025 Reconstituted Complex; Two-hybrid
BTBD1TOP111974011818025 Reconstituted Complex; Two-hybrid
BTBD2TOP111300311818025 Reconstituted Complex; Two-hybrid
BTBD2TOP112077811818025 Reconstituted Complex; Two-hybrid
H2AFYTOP111492717158748 Affinity Capture-MS
H2AFYTOP111300317158748 Affinity Capture-MS
CDT1TOP111300318162579 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
CDT1TOP112355518162579 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
RRP1BTOP111300319710015 Affinity Capture-MS
RRP1BTOP111670819710015 Affinity Capture-MS
Gene Symbol Interactant Interaction ID References Description
TOP1NCL5442810967121 Top1 interacts with Nucleolin
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:98788
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-5390'