AutismKB 2.0

Annotation Details for TOP2B


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Basic Information Top
Gene Symbol:TOP2B ( TOPIIB,top2beta )
Gene Full Name: topoisomerase (DNA) II beta 180kDa
Band: 3p24.2
Quick LinksEntrez ID:7155; OMIM: 126431; Uniprot ID:TOP2B_HUMAN; ENSEMBL ID: ENSG00000077097; HGNC ID: 11990
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000792IDAcolocalizes_withheterochromatin9049244
GO:0005634IDA-nucleus9049244
GO:0005654IDA-nucleoplasm9049244
GO:0005654TAS-nucleoplasm-
GO:0005730IDANOTnucleolus9049244
GO:0005829IDA-cytosol9049244
GO ID Evidence Qualifier GO_term References
GO:0003677IEA-DNA binding-
GO:0003682IDA-chromatin binding9049244
GO:0003918IDA-DNA topoisomerase type II (ATP-hydrolyzing) activity10684600
GO:0005080IPI-protein kinase C binding16611985
GO:0005524IEA-ATP binding-
GO:0008022IPI-protein C-terminus binding10666337
GO:0019899IPI-enzyme binding17567603
GO:0042826IPI-histone deacetylase binding11062478
GO:0046872IEA-metal ion binding-
GO:0046982IPI-protein heterodimerization activity10473615
GO ID Evidence Qualifier GO_term References
GO:0000712IBA-resolution of meiotic recombination intermediates-
GO:0000819IBA-sister chromatid segregation-
GO:0001764IEA-neuron migration-
GO:0006265IDA-DNA topological change10684600
GO:0006312IBA-mitotic recombination-
GO:0007409IEA-axonogenesis-
GO:0016925TAS-protein sumoylation-
GO:0030900IEA-forebrain development-
GO:0044774IBA-mitotic DNA integrity checkpoint-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TOP2BPARP110665216794079 Affinity Capture-Western
TOP2BPARP111300816794079 Affinity Capture-Western
TOP2BCD3E1130088626450 Affinity Capture-Western; Reconstituted Complex
TOP2BCD3E1073548626450 Affinity Capture-Western; Reconstituted Complex
TOP2BCSNK2B11300811710515 Two-hybrid
TOP2BCSNK2B10784311710515 Two-hybrid
TOP2BESR111300816794079 Affinity Capture-Western
TOP2BESR110840316794079 Affinity Capture-Western
TOP2BHDAC111300811062478 11136718 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TOP2BHDAC110931511062478 11136718 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TOP2BHDAC211300811062478 Affinity Capture-Western; Reconstituted Complex
TOP2BHDAC210931611062478 Affinity Capture-Western; Reconstituted Complex
TOP2BPML11138418212063 Affinity Capture-MS
TOP2BPML11300818212063 Affinity Capture-MS
TOP2BRARA11300818212063 Affinity Capture-MS; Reconstituted Complex
TOP2BRARA11184918212063 Affinity Capture-MS; Reconstituted Complex
TOP2BSUMO211300819394292 Affinity Capture-MS
TOP2BSUMO211249719394292 Affinity Capture-MS
TOP2BTOP2A1130068710863 Reconstituted Complex
TOP2BTOP2A1130088710863 Reconstituted Complex
TOPBP1TOP2B1162569461304 Two-hybrid
TOPBP1TOP2B1130089461304 Two-hybrid
TP53TOP2B11301010666337 Affinity Capture-Western; Reconstituted Complex
TP53TOP2B11300810666337 Affinity Capture-Western; Reconstituted Complex
SUMO1TOP2B11300810862613 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SUMO1TOP2B11318810862613 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MTA2TOP2B11300811062478 Affinity Capture-Western
MTA2TOP2B11465211062478 Affinity Capture-Western
BAZ1BTOP2B11449712837248 Affinity Capture-MS; Affinity Capture-Western
BAZ1BTOP2B11300812837248 Affinity Capture-MS; Affinity Capture-Western
SRRM1TOP2B11554416159877 Affinity Capture-MS
SRRM1TOP2B11300816159877 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:98791
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-041008-136'