AutismKB 2.0

Annotation Details for TP53BP1


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Basic Information Top
Gene Symbol:TP53BP1 ( 53BP1,FLJ41424,MGC138366,p202 )
Gene Full Name: tumor protein p53 binding protein 1
Band: 15q15.3
Quick LinksEntrez ID:7158; OMIM: 605230; Uniprot ID:TP53B_HUMAN; ENSEMBL ID: ENSG00000067369; HGNC ID: 11999
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000777IEA-condensed chromosome kinetochore-
GO:0000781IDAcolocalizes_withchromosome, telomeric region15149599
GO:0005634IBA-nucleus-
GO:0005634IDA-nucleus28241136
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm9748285
GO:0016604IDA-nuclear body-
GO:0035861IDA-site of double-strand break23333306
GO ID Evidence Qualifier GO_term References
GO:0001102IPI-RNA polymerase II activating transcription factor binding17805299
GO:0001104IMP-RNA polymerase II transcription cofactor activity17805299
GO:0002039IPI-p53 binding14985081
GO:0003677IEA-DNA binding-
GO:0005515IPI-protein binding11877378
GO:0035064IDA-methylated histone binding22373579
GO:0061649IDA-ubiquitin modification-dependent histone binding23760478
GO ID Evidence Qualifier GO_term References
GO:0000077IBA-DNA damage checkpoint-
GO:0006303IDA-double-strand break repair via nonhomologous end joining23333306
GO:0006303TAS-double-strand break repair via nonhomologous end joining-
GO:0006351IEA-transcription, DNA-templated-
GO:0006974IDA-cellular response to DNA damage stimulus17500065
GO:0016925TAS-protein sumoylation-
GO:0045830IDA-positive regulation of isotype switching23345425
GO:0045830IMP-positive regulation of isotype switching23760478
GO:0045893NAS-positive regulation of transcription, DNA-templated9748285
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter17805299
GO:0051091IC-positive regulation of sequence-specific DNA binding transcription factor activity17805299
GO:0051260IDA-protein homooligomerization23345425
GO:0071481IEA-cellular response to X-ray-
GO:2000042IDA-negative regulation of double-strand break repair via homologous recombination23333306
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TP53BP1ATM11301112447390 12697768 18996087 Biochemical Activity; Reconstituted Complex
TP53BP1ATM10696212447390 12697768 18996087 Biochemical Activity; Reconstituted Complex
TP53BP1BLM11301115364958 Affinity Capture-Western; Co-localization
TP53BP1BLM10711015364958 Affinity Capture-Western; Co-localization
TP53BP1BRCA111301112364621 17525332 Affinity Capture-Western
TP53BP1BRCA110714012364621 17525332 Affinity Capture-Western
TP53BP1CHEK110753615364958 Co-localization
TP53BP1CHEK111301115364958 Co-localization
TP53BP1E2F11082018896460 Affinity Capture-Western; Reconstituted Complex
TP53BP1E2F11130118896460 Affinity Capture-Western; Reconstituted Complex
TP53BP1H2AFX11301112447390 12697768 15364958 Affinity Capture-Western; Co-localization; Protein-peptide
TP53BP1H2AFX10926812447390 12697768 15364958 Affinity Capture-Western; Co-localization; Protein-peptide
TP53BP1NFKB111085710646849 Affinity Capture-Western
TP53BP1NFKB111301110646849 Affinity Capture-Western
TP53BP1RPA111301115856006 Affinity Capture-MS; Affinity Capture-Western
TP53BP1RPA111203715856006 Affinity Capture-MS; Affinity Capture-Western
TP53BP1RPA211301115856006 Affinity Capture-MS; Affinity Capture-Western
TP53BP1RPA211203815856006 Affinity Capture-MS; Affinity Capture-Western
TP53BP1SUMO211301119394292 Affinity Capture-MS
TP53BP1SUMO211249719394292 Affinity Capture-MS
TP53BP1TFDP11128858896460 Reconstituted Complex
TP53BP1TFDP11130118896460 Reconstituted Complex
TP53BP1TP531130118016121 11877378 12110597 12351827 14978302 15364958 15611139 Affinity Capture-Western; Co-crystal Structure; Co-localization; Reconstituted Complex; Two-hybrid
TP53BP1TP531130108016121 11877378 12110597 12351827 14978302 15364958 15611139 Affinity Capture-Western; Co-crystal Structure; Co-localization; Reconstituted Complex; Two-hybrid
DCLRE1ATP53BP111526312446782 Affinity Capture-Western
DCLRE1ATP53BP111301112446782 Affinity Capture-Western
HDAC4TP53BP111301112668657 Affinity Capture-Western
HDAC4TP53BP111510612668657 Affinity Capture-Western
PAXIP1TP53BP111301114576432 15456759 17500065 17925232 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
PAXIP1TP53BP111662514576432 15456759 17500065 17925232 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
DYNLL1TP53BP111420615611139 Affinity Capture-Western; Protein-peptide; Two-hybrid
DYNLL1TP53BP111301115611139 Affinity Capture-Western; Protein-peptide; Two-hybrid
MCPH1TP53BP111301116872911 Co-localization
MCPH1TP53BP112277616872911 Co-localization
USP28TP53BP111301116901786 19615732 Affinity Capture-MS; Affinity Capture-Western
USP28TP53BP112168316901786 19615732 Affinity Capture-MS; Affinity Capture-Western
CHEK2TP53BP111636917525332 Affinity Capture-Western
CHEK2TP53BP111301117525332 Affinity Capture-Western
MDC1TP53BP111301117925396 18986980 Affinity Capture-Western; Co-localization; Reconstituted Complex
MDC1TP53BP111501417925396 18986980 Affinity Capture-Western; Co-localization; Reconstituted Complex
RAD18TP53BP112121219228710 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
RAD18TP53BP111301119228710 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
RNF168TP53BP111301120016603 Co-localization
RNF168TP53BP112792220016603 Co-localization
PIAS4TP53BP111301120016603 Co-localization
PIAS4TP53BP111962420016603 Co-localization
UBE2ITP53BP111317720016603 Co-localization
UBE2ITP53BP111301120016603 Co-localization
RNF8TP53BP111449220016603 Co-localization
RNF8TP53BP111301120016603 Co-localization
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1351320
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-3695'