AutismKB 2.0

Annotation Details for TPM1


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Basic Information Top
Gene Symbol:TPM1 ( C15orf13,CMD1Y,HTM-alpha,TMSA )
Gene Full Name: tropomyosin 1 (alpha)
Band: 15q22.2
Quick LinksEntrez ID:7168; OMIM: 191010; Uniprot ID:TPM1_HUMAN; ENSEMBL ID: ENSG00000140416; HGNC ID: 12010
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001725IDA-stress fiber12686598
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005856TAS-cytoskeleton16130169
GO:0005862TAS-muscle thin filament tropomyosin8205619
GO:0005884IBA-actin filament-
GO:0015629IDA-actin cytoskeleton-
GO:0030017TAS-sarcomere16754800
GO:0031941IEA-filamentous actin-
GO:0032059IMP-bleb12686598
GO:0032587IDA-ruffle membrane12686598
GO ID Evidence Qualifier GO_term References
GO:0003779TAS-actin binding12686598
GO:0005200TAS-structural constituent of cytoskeleton12686598
GO:0005515IPI-protein binding16189514
GO:0008092IPI-cytoskeletal protein binding17987659
GO:0008307TAS-structural constituent of muscle8205619
GO:0051015IBA-actin filament binding-
GO ID Evidence Qualifier GO_term References
GO:0001701IEA-in utero embryonic development-
GO:0003065ISS-positive regulation of heart rate by epinephrine17556658
GO:0006928TAS-movement of cell or subcellular component16130169
GO:0006936TAS-muscle contraction-
GO:0006937TAS-regulation of muscle contraction3336363
GO:0007010TAS-cytoskeleton organization12686598
GO:0007015IBA-actin filament organization-
GO:0008016TAS-regulation of heart contraction8205619
GO:0008360IMP-regulation of cell shape21817107
GO:0030049ISS-muscle filament sliding11136687
GO:0030049TAS-muscle filament sliding-
GO:0030336ISS-negative regulation of cell migration15897890
GO:0031529ISS-ruffle organization15897890
GO:0032781ISS-positive regulation of ATPase activity11136687
GO:0034614IEP-cellular response to reactive oxygen species12686598
GO:0042060ISS-wound healing17721995
GO:0045214IMP-sarcomere organization11273725
GO:0045785ISS-positive regulation of cell adhesion17721995
GO:0051496ISS-positive regulation of stress fiber assembly15897890
GO:0055010IMP-ventricular cardiac muscle tissue morphogenesis11136687
GO:0060048IMP-cardiac muscle contraction11136687
GO:1904706IMP-negative regulation of vascular smooth muscle cell proliferation21817107
GO:1904753IMP-negative regulation of vascular associated smooth muscle cell migration21817107
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TPM1CNN11076642161834 Reconstituted Complex
TPM1CNN11130212161834 Reconstituted Complex
TPM1EGFR11302120029029 PCA
TPM1EGFR10827620029029 PCA
TPM1TNNT11129926822572 Reconstituted Complex
TPM1TNNT11130216822572 Reconstituted Complex
TPM1TNNT21129936746613 Reconstituted Complex
TPM1TNNT21130216746613 Reconstituted Complex
TPM1TPM11130213857586 7568216 Affinity Capture-Western; Reconstituted Complex
TPM2TPM11130213857586 Reconstituted Complex
TPM2TPM11130223857586 Reconstituted Complex
C19orf50TPM112250116189514 Two-hybrid
C19orf50TPM111302116189514 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:98809
  • Data Attributes: MGI curated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-854'