AutismKB 2.0

Annotation Details for TPR


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TPR ( - )
Gene Full Name: translocated promoter region (to activated MET oncogene)
Band: 1q31.1
Quick LinksEntrez ID:7175; OMIM: 189940; Uniprot ID:TPR_HUMAN; ENSEMBL ID: ENSG00000047410; HGNC ID: 12017
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000776IDA-kinetochore20133940
GO:0000776IDANOTkinetochore19273613
GO:0000776IDAcolocalizes_withkinetochore18981471
GO:0005575ND-cellular_component-
GO:0005634IDA-nucleus15654337
GO:0005635IDA-nuclear envelope17098863
GO:0005643IDA-nuclear pore9828100
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm11952838
GO:0005868IDA-cytoplasmic dynein complex20133940
GO:0019898IDA-extrinsic component of membrane12802065
GO:0031965IDA-nuclear membrane9024684
GO:0034399IDA-nuclear periphery9024684
GO:0042405IDA-nuclear inclusion body11514627
GO:0044615IDA-nuclear pore nuclear basket9024684
GO:0072686IDA-mitotic spindle20133940
GO ID Evidence Qualifier GO_term References
GO:0003674ND-molecular_function-
GO:0003682IDA-chromatin binding17897941
GO:0003723IDA-RNA binding22658674
GO:0003729IDA-mRNA binding17897941
GO:0005215IMPNOTtransporter activity11952838
GO:0005487IDA-nucleocytoplasmic transporter activity22253824
GO:0005515IPI-protein binding12802065
GO:0015631IDA-tubulin binding20133940
GO:0031072IDA-heat shock protein binding17897941
GO:0042803IDA-protein homodimerization activity11514627
GO:0043495IMPNOTprotein anchor12802065
GO:0051019IDA-mitogen-activated protein kinase binding18794356
GO:0070840IDA-dynein complex binding20133940
GO ID Evidence Qualifier GO_term References
GO:0000122IMP-negative regulation of transcription from RNA polymerase II promoter21613532
GO:0000189IMP-MAPK import into nucleus18794356
GO:0006404IDA-RNA import into nucleus9864356
GO:0006405IMP-RNA export from nucleus11952838
GO:0006406TAS-mRNA export from nucleus-
GO:0006409TAS-tRNA export from nucleus-
GO:0006606IDANOTprotein import into nucleus9864356
GO:0006606IMPNOTprotein import into nucleus11952838
GO:0006611IMPNOTprotein export from nucleus11952838
GO:0006999IMP-nuclear pore organization15229283
GO:0006999IMPNOTnuclear pore organization11952838
GO:0007077TAS-mitotic nuclear envelope disassembly-
GO:0007094IMP-mitotic spindle assembly checkpoint18981471
GO:0008150ND-biological_process-
GO:0010793IMPNOTregulation of mRNA export from nucleus22253824
GO:0010827TAS-regulation of glucose transport-
GO:0010965IMP-regulation of mitotic sister chromatid separation20133940
GO:0016032TAS-viral process-
GO:0016925TAS-protein sumoylation-
GO:0019083TAS-viral transcription-
GO:0031453IMP-positive regulation of heterochromatin assembly20407419
GO:0031647IMPNOTregulation of protein stability21613532
GO:0031990IDA-mRNA export from nucleus in response to heat stress17897941
GO:0034605IDA-cellular response to heat17897941
GO:0035457ISS-cellular response to interferon-alpha-
GO:0042306IMPNOTregulation of protein import into nucleus22253824
GO:0042307IMP-positive regulation of protein import into nucleus18794356
GO:0043578IMPNOTnuclear matrix organization11952838
GO:0045947IMP-negative regulation of translational initiation21613532
GO:0046825IMPNOTregulation of protein export from nucleus22253824
GO:0046827ISS-positive regulation of protein export from nucleus-
GO:0046832IDA-negative regulation of RNA export from nucleus22253824
GO:0046832IMP-negative regulation of RNA export from nucleus21613532
GO:0051292IMPNOTnuclear pore complex assembly12802065
GO:0051301IEA-cell division-
GO:0060964TAS-regulation of gene silencing by miRNA-
GO:0070849IDA-response to epidermal growth factor18794356
GO:0075733TAS-intracellular transport of virus-
GO:0090267IMP-positive regulation of mitotic cell cycle spindle assembly checkpoint19273613
GO:0090316IMP-positive regulation of intracellular protein transport19273613
GO:1900034TAS-regulation of cellular response to heat-
GO:1901673IMP-regulation of mitotic spindle assembly19273613
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TPRAPC10682120936779 Two-hybrid
TPRAPC11302820936779 Two-hybrid
TPRGTF2E210921617643375 Affinity Capture-MS
TPRGTF2E211302817643375 Affinity Capture-MS
TPRMAP3K411038020936779 Two-hybrid
TPRMAP3K411302820936779 Two-hybrid
TPRNUP9811098211248057 12802065 Affinity Capture-Western; Reconstituted Complex
TPRNUP9811302811248057 12802065 Affinity Capture-Western; Reconstituted Complex
TPRMAPK111158012594221 Biochemical Activity
TPRMAPK111302812594221 Biochemical Activity
TPRSUMO211302819394292 Affinity Capture-MS
TPRSUMO211249719394292 Affinity Capture-MS
NUP205TPR11677712802065 Affinity Capture-Western
NUP205TPR11302812802065 Affinity Capture-Western
NUP107TPR12138612802065 Affinity Capture-Western
NUP107TPR11302812802065 Affinity Capture-Western
NUP93TPR11302812802065 Affinity Capture-Western
NUP93TPR11504112802065 Affinity Capture-Western
NUP153TPR11529712802065 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NUP153TPR11302812802065 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
Gene Symbol Interactant Interaction ID References Description
TPRHTT20931215654337 Htt interacts with Tpr.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1922066
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-6410'