Gene Symbol:	C3 ( AHUS5,ARMD9,ASP,CPAMD1 )
Gene Full Name:	complement component 3
Band:	19p13.3
Quick Links	Entrez ID:718; OMIM: 120700; Uniprot ID:CO3_HUMAN; ENSEMBL ID: ENSG00000125730; HGNC ID: 1318
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005576	TAS	-	extracellular region	-
GO:0005615	IDA	-	extracellular space	16502470
GO:0005788	TAS	-	endoplasmic reticulum lumen	-
GO:0005886	TAS	-	plasma membrane	-
GO:0034774	TAS	-	secretory granule lumen	-
GO:0035578	TAS	-	azurophil granule lumen	-
GO:0070062	IDA	-	extracellular exosome	21362503
GO:0072562	IDA	-	blood microparticle	22516433

GO ID	Evidence	Qualifier	GO_term	References
GO:0004252	TAS	-	serine-type endopeptidase activity	-
GO:0004866	IEA	-	endopeptidase inhibitor activity	-
GO:0005102	TAS	-	receptor binding	9164946
GO:0005515	IPI	-	protein binding	7483825
GO:0031715	IDA	-	C5L2 anaphylatoxin chemotactic receptor binding	15833747

GO ID	Evidence	Qualifier	GO_term	References
GO:0001798	IEA	-	positive regulation of type IIa hypersensitivity	-
GO:0001934	IDA	-	positive regulation of protein phosphorylation	15833747
GO:0001970	IEA	-	positive regulation of activation of membrane attack complex	-
GO:0006508	IEA	-	proteolysis	-
GO:0006631	IEA	-	fatty acid metabolic process	-
GO:0006954	IEA	-	inflammatory response	-
GO:0006955	TAS	-	immune response	4097977
GO:0006956	IMP	-	complement activation	19302245
GO:0006956	TAS	-	complement activation	-
GO:0006957	TAS	-	complement activation, alternative pathway	-
GO:0006958	IEA	-	complement activation, classical pathway	-
GO:0007165	TAS	-	signal transduction	10085065
GO:0007186	TAS	-	G-protein coupled receptor signaling pathway	9164946
GO:0010575	IDA	-	positive regulation of vascular endothelial growth factor production	16452172
GO:0010828	IDA	-	positive regulation of glucose transport	9059512
GO:0010866	IDA	-	regulation of triglyceride biosynthetic process	10432298
GO:0010884	IDA	-	positive regulation of lipid storage	9555951
GO:0010951	IEA	-	negative regulation of endopeptidase activity	-
GO:0030449	TAS	-	regulation of complement activation	-
GO:0043312	TAS	-	neutrophil degranulation	-
GO:0043687	TAS	-	post-translational protein modification	-
GO:0044267	TAS	-	cellular protein metabolic process	-
GO:0045745	IDA	-	positive regulation of G-protein coupled receptor protein signaling pathway	15833747
GO:0045766	IEA	-	positive regulation of angiogenesis	-
GO:0050776	TAS	-	regulation of immune response	-
GO:2000427	IMP	-	positive regulation of apoptotic cell clearance	19302245

Gene Symbol	Interactant	Interaction ID	References	Description
C3	CFB	107098	11367533	Reconstituted Complex
C3	CFB	107179	11367533	Reconstituted Complex
CFP	C3	107179	3421908 11513971	Reconstituted Complex
CFP	C3	111222	3421908 11513971	Reconstituted Complex
ITGAX	C3	107179	4062888	Reconstituted Complex
ITGAX	C3	109893	4062888	Reconstituted Complex
CFI	C3	107179	8648130 9291131	Biochemical Activity; Reconstituted Complex
CFI	C3	109652	8648130 9291131	Biochemical Activity; Reconstituted Complex
CFH	C3	107179	9291131 11367533	Reconstituted Complex
CFH	C3	109324	9291131 11367533	Reconstituted Complex
CFHR4	C3	107179	10622723	Reconstituted Complex
CFHR4	C3	116085	10622723	Reconstituted Complex
CFHR3	C3	107179	10622723	Reconstituted Complex
CFHR3	C3	116086	10622723	Reconstituted Complex
CFHR5	C3	107179	11058592	Reconstituted Complex
CFHR5	C3	123503	11058592	Reconstituted Complex
C5	C3	107188	11367533	Reconstituted Complex
C5	C3	107179	11367533	Reconstituted Complex
CPN1	C3	107761	11939578	Biochemical Activity
CPN1	C3	107179	11939578	Biochemical Activity

AutismKB 2.0

Annotation Details for C3