AutismKB 2.0

Annotation Details for HSP90B1


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Basic Information Top
Gene Symbol:HSP90B1 ( ECGP,GP96,GRP94,TRA1 )
Gene Full Name: heat shock protein 90kDa beta (Grp94), member 1
Band: 12q23.3
Quick LinksEntrez ID:7184; OMIM: 191175; Uniprot ID:ENPL_HUMAN; ENSEMBL ID: ENSG00000166598; HGNC ID: 12028
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005634IDA-nucleus21630459
GO:0005783IDA-endoplasmic reticulum-
GO:0005783TAS-endoplasmic reticulum16130169
GO:0005788IDA-endoplasmic reticulum lumen10497210
GO:0005788TAS-endoplasmic reticulum lumen-
GO:0005789IDA-endoplasmic reticulum membrane10497210
GO:0005829IDA-cytosol9596688
GO:0005886IEA-plasma membrane-
GO:0005925IDA-focal adhesion21423176
GO:0016020IDA-membrane19946888
GO:0030496IDA-midbody15166316
GO:0031012IDA-extracellular matrix23658023
GO:0034663IEA-endoplasmic reticulum chaperone complex-
GO:0042470IEA-melanosome-
GO:0048471IDA-perinuclear region of cytoplasm10497210
GO:0070062IDA-extracellular exosome19199708
GO:0071682TAS-endocytic vesicle lumen-
GO ID Evidence Qualifier GO_term References
GO:0003723IDA-RNA binding11958450
GO:0005509TAS-calcium ion binding10497210
GO:0005515IPI-protein binding9596688
GO:0005524IEA-ATP binding-
GO:0019903IDA-protein phosphatase binding19000834
GO:0046790IPI-virion binding11958450
GO:0050750IDA-low-density lipoprotein particle receptor binding15082773
GO:0051082IEA-unfolded protein binding-
GO ID Evidence Qualifier GO_term References
GO:0001666IDA-response to hypoxia15620698
GO:0002224TAS-toll-like receptor signaling pathway-
GO:0006898TAS-receptor-mediated endocytosis-
GO:0015031NAS-protein transport15845869
GO:0030433IMP-ubiquitin-dependent ERAD pathway18264092
GO:0030970IMP-retrograde protein transport, ER to cytosol25660456
GO:0031247IDA-actin rod assembly19000834
GO:0034975TAS-protein folding in endoplasmic reticulum22013210
GO:0034976TAS-response to endoplasmic reticulum stress22934019
GO:0036500TAS-ATF6-mediated unfolded protein response-
GO:0043066IMP-negative regulation of apoptotic process10497210
GO:0043066TAS-negative regulation of apoptotic process16130169
GO:0043666IDA-regulation of phosphoprotein phosphatase activity19000834
GO:0043687TAS-post-translational protein modification-
GO:0044267TAS-cellular protein metabolic process-
GO:0051208NAS-sequestering of calcium ion15192333
GO:0071318IDA-cellular response to ATP19000834
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HSP90B1BIRC210682618239673 Affinity Capture-Western; FRET
HSP90B1BIRC211303618239673 Affinity Capture-Western; FRET
HSP90B1APOB1068359694898 12397072 Affinity Capture-RNA; Affinity Capture-Western; Co-fractionation
HSP90B1APOB1130369694898 12397072 Affinity Capture-RNA; Affinity Capture-Western; Co-fractionation
HSP90B1CSNK2A110784111557039 Reconstituted Complex
HSP90B1CSNK2A111303611557039 Reconstituted Complex
HSP90B1CSNK2A210784211557039 Reconstituted Complex
HSP90B1CSNK2A211303611557039 Reconstituted Complex
HSP90B1EGFR11303620029029 PCA
HSP90B1EGFR10827620029029 PCA
HSP90B1ERBB21130368617772 Affinity Capture-Western
HSP90B1ERBB21083768617772 Affinity Capture-Western
HSP90B1FANCA10847215082718 Affinity Capture-MS
HSP90B1FANCA11303615082718 Affinity Capture-MS
HSP90B1FANCC11303614499622 Two-hybrid
HSP90B1FANCC10847314499622 Two-hybrid
HSP90B1MAPK611303620936779 Two-hybrid
HSP90B1MAPK611158320936779 Two-hybrid
HSP90B1SMARCA411303611726552 Affinity Capture-Western
HSP90B1SMARCA411248111726552 Affinity Capture-Western
HSP90B1SMARCC111303611726552 Affinity Capture-Western
HSP90B1SMARCC111248311726552 Affinity Capture-Western
HSP90B1SMARCC211303611726552 Affinity Capture-Western
HSP90B1SMARCC211248511726552 Affinity Capture-Western
VWFHSP90B111328910887119 Affinity Capture-Western
VWFHSP90B111303610887119 Affinity Capture-Western
EIF2AK3HSP90B111484011907036 Affinity Capture-Western
EIF2AK3HSP90B111303611907036 Affinity Capture-Western
RAE1HSP90B111303619615732 Affinity Capture-MS
RAE1HSP90B111405419615732 Affinity Capture-MS
UBA5HSP90B112296420562859 Affinity Capture-MS
UBA5HSP90B111303620562859 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:98817
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-031002-1'