AutismKB 2.0

Annotation Details for TRPC4


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Basic Information Top
Gene Symbol:TRPC4 ( HTRP4,MGC119570,MGC119571,MGC119572,MGC119573,TRP4 )
Gene Full Name: transient receptor potential cation channel, subfamily C, member 4
Band: 13q13.3
Quick LinksEntrez ID:7223; OMIM: 603651; Uniprot ID:TRPC4_HUMAN; ENSEMBL ID: ENSG00000133107; HGNC ID: 12336
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886IDA-plasma membrane16254212
GO:0005886TAS-plasma membrane-
GO:0005887IBA-integral component of plasma membrane-
GO:0005901IEA-caveola-
GO:0005911IDAcolocalizes_withcell-cell junction19996314
GO:0009986IDA-cell surface19996314
GO:0016323IDA-basolateral plasma membrane19996314
GO:0030863IDA-cortical cytoskeleton16254212
GO:0034704IDA-calcium channel complex20164195
GO:0043234IEA-protein complex-
GO ID Evidence Qualifier GO_term References
GO:0005262TAS-calcium channel activity-
GO:0005515IPI-protein binding15757897
GO:0008013IPI-beta-catenin binding19996314
GO:0015279IMP-store-operated calcium channel activity16254212
GO:0045296IPI-cadherin binding19996314
GO:0070679IEA-inositol 1,4,5 trisphosphate binding-
GO ID Evidence Qualifier GO_term References
GO:0006816TAS-calcium ion transport8646775
GO:0006828IBA-manganese ion transport-
GO:0014051IEA-gamma-aminobutyric acid secretion-
GO:0048709IEA-oligodendrocyte differentiation-
GO:0051480IBA-regulation of cytosolic calcium ion concentration-
GO:0070509IDA-calcium ion import19996314
GO:0070588TAS-calcium ion transmembrane transport-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TRPC4ITPR111307411163362 14505576 Affinity Capture-Western; Two-hybrid
TRPC4ITPR110991311163362 14505576 Affinity Capture-Western; Two-hybrid
TRPC4ITPR211307411163362 Two-hybrid
TRPC4ITPR210991411163362 Two-hybrid
TRPC4ITPR311307411163362 11290752 Reconstituted Complex; Two-hybrid
TRPC4ITPR310991511163362 11290752 Reconstituted Complex; Two-hybrid
TRPC4TRPC111307112032305 12857742 Affinity Capture-Western; FRET
TRPC4TRPC111307412032305 12857742 Affinity Capture-Western; FRET
TRPC4TRPC311307312857742 Affinity Capture-Western
TRPC4TRPC311307412857742 Affinity Capture-Western
TRPC4TRPC411307412032305 Affinity Capture-Western; FRET
TRPC5TRPC411307512032305 Affinity Capture-Western; FRET
TRPC5TRPC411307412032305 Affinity Capture-Western; FRET
TRPC6TRPC411307612857742 Affinity Capture-Western
TRPC6TRPC411307412857742 Affinity Capture-Western
HOMER3TRPC411484314505576 Affinity Capture-Western
HOMER3TRPC411307414505576 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:109525
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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