AutismKB 2.0

Annotation Details for TSC2


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Basic Information Top
Gene Symbol:TSC2 ( FLJ43106,LAM,TSC4 )
Gene Full Name: tuberous sclerosis 2
Band: 16p13.3
Quick LinksEntrez ID:7249; OMIM: 191092; Uniprot ID:TSC2_HUMAN; ENSEMBL ID: ENSG00000103197; HGNC ID: 12363
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus17114346
GO:0005634IDANOTnucleus16636147
GO:0005737IDA-cytoplasm9580671
GO:0005737IDAcolocalizes_withcytoplasm17114346
GO:0005764IDA-lysosome25936802
GO:0005794IDA-Golgi apparatus8806680
GO:0005794IDANOTGolgi apparatus10585443
GO:0005829IDA-cytosol10585443
GO:0005829TAS-cytosol-
GO:0016020IDA-membrane16636147
GO:0033596IDA-TSC1-TSC2 complex9580671
GO:0048471IDA-perinuclear region of cytoplasm8806680
GO ID Evidence Qualifier GO_term References
GO:0005096IDA-GTPase activator activity9045618
GO:0005515IPI-protein binding9580671
GO:0019902IDA-phosphatase binding19389623
GO:0031267IPI-small GTPase binding25936802
GO:0042803IPI-protein homodimerization activity10585443
GO ID Evidence Qualifier GO_term References
GO:0001843ISS-neural tube closure-
GO:0006469ISS-negative regulation of protein kinase activity-
GO:0006606ISS-protein import into nucleus-
GO:0006897TAS-endocytosis9045618
GO:0007050TAS-cell cycle arrest-
GO:0007507ISS-heart development-
GO:0008104ISS-protein localization-
GO:0008285ISS-negative regulation of cell proliferation-
GO:0014067ISS-negative regulation of phosphatidylinositol 3-kinase signaling-
GO:0016032IEA-viral process-
GO:0016192TAS-vesicle-mediated transport9045618
GO:0016239IGI-positive regulation of macroautophagy23778976
GO:0030100ISS-regulation of endocytosis-
GO:0030178IBA-negative regulation of Wnt signaling pathway-
GO:0032007IBA-negative regulation of TOR signaling-
GO:0032007IGI-negative regulation of TOR signaling23778976
GO:0043276IGI-anoikis23778976
GO:0043491ISS-protein kinase B signaling-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0046626ISS-regulation of insulin receptor signaling pathway-
GO:0046627IBA-negative regulation of insulin receptor signaling pathway-
GO:0048009ISS-insulin-like growth factor receptor signaling pathway-
GO:0050918ISS-positive chemotaxis-
GO:0051056IEA-regulation of small GTPase mediated signal transduction-
GO:0051726IBA-regulation of cell cycle-
GO:0051898IBA-negative regulation of protein kinase B signaling-
GO:0051898ISS-negative regulation of protein kinase B signaling-
GO:0061024TAS-membrane organization-
GO:1901525NAS-negative regulation of macromitophagy26735435
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TSC2AKT111310012167664 15342917 Affinity Capture-Western; Reconstituted Complex
TSC2AKT110671012167664 15342917 Affinity Capture-Western; Reconstituted Complex
TSC2CCND111310016357142 Affinity Capture-Western
TSC2CCND110706716357142 Affinity Capture-Western
TSC2CAV110730512147258 Co-purification
TSC2CAV111310012147258 Co-purification
TSC2CCND211310016357142 Affinity Capture-Western
TSC2CCND210733416357142 Affinity Capture-Western
TSC2CCND311310016357142 Affinity Capture-Western
TSC2CCND310733616357142 Affinity Capture-Western
TSC2CDKN1B11310015355997 Affinity Capture-Western
TSC2CDKN1B10746115355997 Affinity Capture-Western
TSC2FOXO111310017077083 Affinity Capture-Western; Co-localization; Reconstituted Complex
TSC2FOXO110859717077083 Affinity Capture-Western; Co-localization; Reconstituted Complex
TSC2GSK3B11310012511557 16959574 Affinity Capture-Western; Biochemical Activity
TSC2GSK3B10918712511557 16959574 Affinity Capture-Western; Biochemical Activity
TSC2PAM11110114559897 Affinity Capture-Western; Co-localization; Two-hybrid
TSC2PAM11310014559897 Affinity Capture-Western; Co-localization; Two-hybrid
TSC2PLK111310016339216 Affinity Capture-Western
TSC2PLK111136216339216 Affinity Capture-Western
TSC2PRKAA111310014651849 15261145 Affinity Capture-Western; Reconstituted Complex
TSC2PRKAA111154914651849 15261145 Affinity Capture-Western; Reconstituted Complex
TSC2MAPK111158015851026 Affinity Capture-Western; Reconstituted Complex
TSC2MAPK111310015851026 Affinity Capture-Western; Reconstituted Complex
TSC2PTK211310017043358 Affinity Capture-Western; Reconstituted Complex
TSC2PTK211171917043358 Affinity Capture-Western; Reconstituted Complex
TSC2RAB5A11310012147258 Co-purification
TSC2RAB5A11180612147258 Co-purification
TSC2RALA11310012842888 Affinity Capture-Western
TSC2RALA11183412842888 Affinity Capture-Western
TSC2RAP1A11310012147258 12842888 Affinity Capture-Western; Co-purification
TSC2RAP1A11184112147258 12842888 Affinity Capture-Western; Co-purification
TSC2RHEB11310012771962 12820960 12842888 12869586 15854902 17077083 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
TSC2RHEB11194112771962 12820960 12842888 12869586 15854902 17077083 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
TSC2RPS6KA111310015342917 15757502 Affinity Capture-Western; Reconstituted Complex
TSC2RPS6KA111210915342917 15757502 Affinity Capture-Western; Reconstituted Complex
TSC2SKP211310015355997 Phenotypic Suppression
TSC2SKP211239315355997 Phenotypic Suppression
TSC2TSC11131009580671 10807585 10915759 11175345 11290735 11741832 11741833 12167664 12176984 12511557 14551205 14651849 15340059 15851026 15963462 16339216 16424383 16636147 17077083 17658474 Affinity Capture-MS; Affinity Capture-Western; Co-localization; Two-hybrid
TSC2TSC11130999580671 10807585 10915759 11175345 11290735 11741832 11741833 12167664 12176984 12511557 14551205 14651849 15340059 15851026 15963462 16339216 16424383 16636147 17077083 17658474 Affinity Capture-MS; Affinity Capture-Western; Co-localization; Two-hybrid
YWHABTSC211310012176984 12364343 12468542 12582162 16636147 Affinity Capture-Western; Two-hybrid
YWHABTSC211336112176984 12364343 12468542 12582162 16636147 Affinity Capture-Western; Two-hybrid
YWHAZTSC211310012176984 Reconstituted Complex; Two-hybrid
YWHAZTSC211336612176984 Reconstituted Complex; Two-hybrid
AXIN1TSC211310012511557 Affinity Capture-Western
AXIN1TSC211390912511557 Affinity Capture-Western
UBE3ATSC211310015175323 18298802 Affinity Capture-Western; Reconstituted Complex
UBE3ATSC211318515175323 18298802 Affinity Capture-Western; Reconstituted Complex
YWHAQTSC211616817353931 Affinity Capture-MS
YWHAQTSC211310017353931 Affinity Capture-MS
TBC1D7TSC211310017658474 Affinity Capture-Western; Reconstituted Complex
TBC1D7TSC211941217658474 Affinity Capture-Western; Reconstituted Complex
UBCTSC211310018298802 Affinity Capture-Western
UBCTSC211316418298802 Affinity Capture-Western
FBXW5TSC211310018381890 Affinity Capture-Western
FBXW5TSC211996718381890 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
TSC2TSC2_A1/A2 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:102548
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-2702'