AutismKB 2.0

Annotation Details for C5


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Basic Information Top
Gene Symbol:C5 ( CPAMD4,FLJ17816,FLJ17822,MGC142298 )
Gene Full Name: complement component 5
Band: 9q33.2
Quick LinksEntrez ID:727; OMIM: 120900; Uniprot ID:CO5_HUMAN; ENSEMBL ID: ENSG00000106804; HGNC ID: 1331
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005579IDA-membrane attack complex22832194
GO:0005615IEA-extracellular space-
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0004866IEA-endopeptidase inhibitor activity-
GO:0005102TAS-receptor binding9590258
GO:0005515IPI-protein binding21217642
GO:0008009TAS-chemokine activity10820279
GO ID Evidence Qualifier GO_term References
GO:0000187TAS-activation of MAPK activity7649993
GO:0001701IEA-in utero embryonic development-
GO:0006935TAS-chemotaxis10820279
GO:0006950TAS-response to stress9590258
GO:0006954IEA-inflammatory response-
GO:0006956TAS-complement activation-
GO:0006957IEA-complement activation, alternative pathway-
GO:0006958IEA-complement activation, classical pathway-
GO:0007166TAS-cell surface receptor signaling pathway10820279
GO:0007186TAS-G-protein coupled receptor signaling pathway8898085
GO:0010575IDA-positive regulation of vascular endothelial growth factor production14566334
GO:0010760IDA-negative regulation of macrophage chemotaxis14566334
GO:0010951IEA-negative regulation of endopeptidase activity-
GO:0019835IEA-cytolysis-
GO:0030449TAS-regulation of complement activation-
GO:0045766IEA-positive regulation of angiogenesis-
GO:0060326IEA-cell chemotaxis-
GO:0090197IDA-positive regulation of chemokine secretion14566334
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
C5C310718811367533 Reconstituted Complex
C5C310717911367533 Reconstituted Complex
C6C51071881387399 2808363 Co-fractionation; Reconstituted Complex
C6C51071901387399 2808363 Co-fractionation; Reconstituted Complex
C7C51071881387399 Reconstituted Complex
C7C51071911387399 Reconstituted Complex
C8BC51071883624872 Reconstituted Complex
C8BC51071933624872 Reconstituted Complex
C5AR1C51071889553099 Reconstituted Complex
C5AR1C51071899553099 Reconstituted Complex
CPB2C510775311939578 Biochemical Activity
CPB2C510718811939578 Biochemical Activity
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96031
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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