AutismKB 2.0

Annotation Details for TTK


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Basic Information Top
Gene Symbol:TTK ( CT96,ESK,FLJ38280,MPS1,MPS1L1,PYT )
Gene Full Name: TTK protein kinase
Band: 6q14.1
Quick LinksEntrez ID:7272; OMIM: 604092; Uniprot ID:TTK_HUMAN; ENSEMBL ID: ENSG00000112742; HGNC ID: 12401
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000776IEA-kinetochore-
GO:0005737IDA-cytoplasm25468996
GO:0005819TAS-spindle10366450
GO:0016020IDA-membrane19946888
GO ID Evidence Qualifier GO_term References
GO:0004674IEA-protein serine/threonine kinase activity-
GO:0004712IEA-protein serine/threonine/tyrosine kinase activity-
GO:0004713IEA-protein tyrosine kinase activity-
GO:0005515IPI-protein binding19273613
GO:0005524IEA-ATP binding-
GO:0042803IEA-protein homodimerization activity-
GO ID Evidence Qualifier GO_term References
GO:0007051TAS-spindle organization10366450
GO:0007052TAS-mitotic spindle organization7737118
GO:0007094TAS-mitotic spindle assembly checkpoint10366450
GO:0008284TAS-positive regulation of cell proliferation1639825
GO:0010862TAS-positive regulation of pathway-restricted SMAD protein phosphorylation19018011
GO:0016321IEA-female meiosis chromosome segregation-
GO:0018105IEA-peptidyl-serine phosphorylation-
GO:0018107IEA-peptidyl-threonine phosphorylation-
GO:0018108IEA-peptidyl-tyrosine phosphorylation-
GO:0033316IEA-meiotic spindle assembly checkpoint-
GO:0034501IEA-protein localization to kinetochore-
GO:0046777IEA-protein autophosphorylation-
GO:0051304IEA-chromosome separation-
GO:1903096IEA-protein localization to meiotic spindle midzone-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TTKCDC2710743112686615 Affinity Capture-Western
TTKCDC2711312312686615 Affinity Capture-Western
CDC16TTK11440012686615 Affinity Capture-Western
CDC16TTK11312312686615 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1194921
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030123-1'