AutismKB 2.0

Annotation Details for TTN


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TTN ( CMD1G,CMH9,CMPD4,DKFZp451N061,EOMFC,FLJ26020,FLJ26409,FLJ32040,FLJ34413,FLJ39564,FLJ43066,HMERF,LGMD2J,TMD )
Gene Full Name: titin
Band: 2q31.2
Quick LinksEntrez ID:7273; OMIM: 188840; Uniprot ID:Q4ZG20_HUMAN; ENSEMBL ID: ENSG00000155657; HGNC ID: 12403
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000794IDA-condensed nuclear chromosome9548712
GO:0005576TAS-extracellular region-
GO:0005829TAS-cytosol-
GO:0005859IBA-muscle myosin complex-
GO:0030018IDA-Z disc9501083
GO:0031430IBA-M band-
GO:0031674IDA-I band9817758
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0002020IPI-protease binding9642272
GO:0004674IDA-protein serine/threonine kinase activity9804419
GO:0004713IDA-protein tyrosine kinase activity18765796
GO:0005509IDA-calcium ion binding7607248
GO:0005515IPI-protein binding9501083
GO:0005516TAS-calmodulin binding10481174
GO:0005524IEA-ATP binding-
GO:0008307IMP-structural constituent of muscle9817758
GO:0008307TAS-structural constituent of muscle7569978
GO:0019899IPI-enzyme binding18310072
GO:0019901IPI-protein kinase binding23283722
GO:0031433IPI-telethonin binding11846417
GO:0031433ISS-telethonin binding-
GO:0042802IPI-identical protein binding9804419
GO:0042805IDA-actinin binding9501083
GO:0042805IPI-actinin binding11846417
GO:0043621IDA-protein self-association9804419
GO:0051015IDA-actin filament binding9501083
GO:0051371IPI-muscle alpha-actinin binding9501083
GO:0097493TAS-structural molecule activity conferring elasticity23283722
GO ID Evidence Qualifier GO_term References
GO:0002576TAS-platelet degranulation-
GO:0003300IMP-cardiac muscle hypertrophy11846417
GO:0006936NAS-muscle contraction10481174
GO:0006936TAS-muscle contraction11911777
GO:0006941TAS-striated muscle contraction7569978
GO:0007076IEP-mitotic chromosome condensation9548712
GO:0010628IGI-positive regulation of gene expression25152160
GO:0010628IMP-positive regulation of gene expression25152160
GO:0010737IMP-protein kinase A signaling25152160
GO:0018108IEA-peptidyl-tyrosine phosphorylation-
GO:0030049TAS-muscle filament sliding-
GO:0030240IMP-skeletal muscle thin filament assembly9817758
GO:0030241IMP-skeletal muscle myosin thick filament assembly9817758
GO:0035995IDA-detection of muscle stretch18765796
GO:0035995TAS-detection of muscle stretch12507422
GO:0045214IMP-sarcomere organization9817758
GO:0045859IMP-regulation of protein kinase activity9804419
GO:0048739IMP-cardiac muscle fiber development9817758
GO:0048769IMP-sarcomerogenesis9817758
GO:0050714IGI-positive regulation of protein secretion25152160
GO:0050714IMP-positive regulation of protein secretion25152160
GO:0050790IMP-regulation of catalytic activity9804419
GO:0051592IDA-response to calcium ion7607248
GO:0055003IMP-cardiac myofibril assembly9817758
GO:0055008IMP-cardiac muscle tissue morphogenesis9817758
GO:0060048IMP-cardiac muscle contraction11846417
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TTNACTN111312411305911 Reconstituted Complex
TTNACTN110660211305911 Reconstituted Complex
TTNANK111312412444090 Reconstituted Complex; Two-hybrid
TTNANK110678312444090 Reconstituted Complex; Two-hybrid
TTNCAPN31131248537379 9642272 Two-hybrid
TTNCAPN31072758537379 9642272 Two-hybrid
TTNFHL211312412432079 Reconstituted Complex; Two-hybrid
TTNFHL210856512432079 Reconstituted Complex; Two-hybrid
TTNMYBPC31106928631348 Far Western
TTNMYBPC31131248631348 Far Western
TCAPTTN1141279645487 9804419 9817758 12446666 Biochemical Activity; Co-purification; Reconstituted Complex; Two-hybrid
TCAPTTN1131249645487 9804419 9817758 12446666 Biochemical Activity; Co-purification; Reconstituted Complex; Two-hybrid
TRIM63TTN11312411243782 15967462 Reconstituted Complex; Two-hybrid
TRIM63TTN12419511243782 15967462 Reconstituted Complex; Two-hybrid
OBSCNTTN11312411448995 Reconstituted Complex; Two-hybrid
OBSCNTTN12384711448995 Reconstituted Complex; Two-hybrid
ANKRD2TTN11766914583192 Reconstituted Complex
ANKRD2TTN11312414583192 Reconstituted Complex
ANKRD23TTN12833314583192 Reconstituted Complex; Two-hybrid
ANKRD23TTN11312414583192 Reconstituted Complex; Two-hybrid
ANKRD1TTN11797514583192 Reconstituted Complex; Two-hybrid
ANKRD1TTN11312414583192 Reconstituted Complex; Two-hybrid
MYPNTTN12418514583192 Two-hybrid
MYPNTTN11312414583192 Two-hybrid
PUF60TTN11312417353931 Affinity Capture-MS
PUF60TTN11650217353931 Affinity Capture-MS
ASF1BTTN12084517353931 Affinity Capture-MS
ASF1BTTN11312417353931 Affinity Capture-MS
Gene Symbol Interactant Interaction ID References Description
TTNFHL221775612432079 An unspecified isoform of FHL2 (DRAL) interacts with TTN (titin).
TCAPTTN25761415802564 Titin interacts with telethonin. This interaction was modelled on a demonstrated interaction between human Titin and telethonin from unspecified species.
SQSTM1TTN25761215802564 Titin interacts with p62. This interaction was modelled on a demonstrated interaction between human Titin and rat p62.
KYTTN21741315385448 KY interacts with an unspecified isoform of TTN. This interaction was modeled on a demonstrated interaction between mouse KY and human TTN.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:98864
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030113-2'