AutismKB 2.0

Annotation Details for TXK


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Basic Information Top
Gene Symbol:TXK ( BTKL,MGC22473,PSCTK5,PTK4,RLK,TKL )
Gene Full Name: TXK tyrosine kinase
Band: 4p12
Quick LinksEntrez ID:7294; OMIM: 600058; Uniprot ID:TXK_HUMAN; ENSEMBL ID: ENSG00000074966; HGNC ID: 12434
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus10523612
GO:0005737IDA-cytoplasm10523612
GO:0031234IBA-extrinsic component of cytoplasmic side of plasma membrane-
GO ID Evidence Qualifier GO_term References
GO:0000978IDA-RNA polymerase II core promoter proximal region sequence-specific DNA binding11859127
GO:0001012IDA-RNA polymerase II regulatory region DNA binding11859127
GO:0001077IDA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding11859127
GO:0004715IBA-non-membrane spanning protein tyrosine kinase activity-
GO:0005102IBANOTreceptor binding-
GO:0005515IPI-protein binding17177976
GO:0005524IEA-ATP binding-
GO ID Evidence Qualifier GO_term References
GO:0001816ISS-cytokine production-
GO:0002250ISS-adaptive immune response-
GO:0006357IDA-regulation of transcription from RNA polymerase II promoter11859127
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0006468IDA-protein phosphorylation17177976
GO:0007169IBA-transmembrane receptor protein tyrosine kinase signaling pathway-
GO:0007202ISS-activation of phospholipase C activity-
GO:0007229IBA-integrin-mediated signaling pathway-
GO:0010543IBA-regulation of platelet activation-
GO:0030154IBA-cell differentiation-
GO:0032729IDA-positive regulation of interferon-gamma production10523612
GO:0038083IBA-peptidyl-tyrosine autophosphorylation-
GO:0042127IBA-regulation of cell proliferation-
GO:0042246IBA-tissue regeneration-
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter11859127
GO:0046777IDA-protein autophosphorylation12081135
GO:0050852ISS-T cell receptor signaling pathway-
GO:0060335IDA-positive regulation of interferon-gamma-mediated signaling pathway11859127
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
YTHDC1TXK12487115175272 Biochemical Activity
YTHDC1TXK11314515175272 Biochemical Activity
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:102960
  • Data Attributes: MGI curated and HomoloGene calculated
No data