AutismKB 2.0

Annotation Details for TYK2


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Basic Information Top
Gene Symbol:TYK2 ( JTK1 )
Gene Full Name: tyrosine kinase 2
Band: 19p13.2
Quick LinksEntrez ID:7297; OMIM: 176941; Uniprot ID:TYK2_HUMAN; ENSEMBL ID: ENSG00000105397; HGNC ID: 12440
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus10502458
GO:0005737IDA-cytoplasm10502458
GO:0005829TAS-cytosol-
GO:0005856IEA-cytoskeleton-
GO:0031234IBA-extrinsic component of cytoplasmic side of plasma membrane-
GO:0070062IDA-extracellular exosome20458337
GO ID Evidence Qualifier GO_term References
GO:0004713EXP-protein tyrosine kinase activity1386289
GO:0004713TAS-protein tyrosine kinase activity-
GO:0004715IBA-non-membrane spanning protein tyrosine kinase activity-
GO:0004715TAS-non-membrane spanning protein tyrosine kinase activity-
GO:0005131IPI-growth hormone receptor binding10502458
GO:0005515IPI-protein binding21516116
GO:0005524IEA-ATP binding-
GO:0031702IEA-type 1 angiotensin receptor binding-
GO ID Evidence Qualifier GO_term References
GO:0006468TAS-protein phosphorylation2216457
GO:0007169IBA-transmembrane receptor protein tyrosine kinase signaling pathway-
GO:0016477IBA-cell migration-
GO:0030154IBA-cell differentiation-
GO:0035556IEA-intracellular signal transduction-
GO:0038083IBA-peptidyl-tyrosine autophosphorylation-
GO:0042127IBA-regulation of cell proliferation-
GO:0045087IBA-innate immune response-
GO:0060337TAS-type I interferon signaling pathway-
GO:0060338TAS-regulation of type I interferon-mediated signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TYK2CBL1073158780698 Affinity Capture-Western
TYK2CBL1131488780698 Affinity Capture-Western
TYK2CRKL1077899374471 Affinity Capture-Western
TYK2CRKL1131489374471 Affinity Capture-Western
TYK2FYN1131489196040 Affinity Capture-Western; Reconstituted Complex
TYK2FYN1088109196040 Affinity Capture-Western; Reconstituted Complex
TYK2GHR10895710502458 Affinity Capture-Western
TYK2GHR11314810502458 Affinity Capture-Western
TYK2IFNAR11096769733772 15337770 18474601 Affinity Capture-Western; Reconstituted Complex
TYK2IFNAR11131489733772 15337770 18474601 Affinity Capture-Western; Reconstituted Complex
TYK2IL6ST1131489388212 Affinity Capture-Western
TYK2IL6ST1097869388212 Affinity Capture-Western
TYK2IL13RA110981110409622 Affinity Capture-Western
TYK2IL13RA111314810409622 Affinity Capture-Western
TYK2JAK11099197589562 Affinity Capture-Western
TYK2JAK11131487589562 Affinity Capture-Western
TYK2LYN1102459633884 Reconstituted Complex
TYK2LYN1131489633884 Reconstituted Complex
TYK2PLAUR1113459417082 Affinity Capture-Western
TYK2PLAUR1131489417082 Affinity Capture-Western
TYK2PTPN111173611694501 Affinity Capture-Western
TYK2PTPN111314811694501 Affinity Capture-Western
TYK2PTPN61117427629131 Affinity Capture-Western; Biochemical Activity
TYK2PTPN61131487629131 Affinity Capture-Western; Biochemical Activity
TYK2STAT111264912960323 Biochemical Activity
TYK2STAT111314812960323 Biochemical Activity
TYK2TYK21131487589562 Affinity Capture-Western
IRS2TYK21142098550573 Reconstituted Complex
IRS2TYK21131488550573 Reconstituted Complex
PRMT5TYK211568810531356 Reconstituted Complex
PRMT5TYK211314810531356 Reconstituted Complex
VAV1TYK211325210673353 Affinity Capture-Western
VAV1TYK211314810673353 Affinity Capture-Western
XRCC5TYK211335310673353 Affinity Capture-Western
XRCC5TYK211314810673353 Affinity Capture-Western
STAM2TYK211554810899310 Affinity Capture-Western
STAM2TYK211314810899310 Affinity Capture-Western
ELP2TYK212054110954736 Affinity Capture-Western
ELP2TYK211314810954736 Affinity Capture-Western
GNB2L1TYK211314812960323 Affinity Capture-Western; Reconstituted Complex
GNB2L1TYK211567112960323 Affinity Capture-Western; Reconstituted Complex
Gene Symbol Interactant Interaction ID References Description
TYK2IL12RB12019229038232 An unspecified isoform of IL12RB1 interacts with Tyk2.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1929470
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-071116-4'