AutismKB 2.0

Annotation Details for TYROBP


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Basic Information Top
Gene Symbol:TYROBP ( DAP12,KARAP,PLOSL )
Gene Full Name: TYRO protein tyrosine kinase binding protein
Band: 19q13.12
Quick LinksEntrez ID:7305; OMIM: 604142; Uniprot ID:TYOBP_HUMAN; ENSEMBL ID: ENSG00000011600; HGNC ID: 12449
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane9490415
GO:0009986IDA-cell surface15294961
GO:0030667TAS-secretory granule membrane-
GO ID Evidence Qualifier GO_term References
GO:0005057TAS-signal transducer activity, downstream of receptor9490415
GO:0005102IPI-receptor binding11602640
GO:0005515IPI-protein binding10940905
GO:0042802IPI-identical protein binding20890284
GO ID Evidence Qualifier GO_term References
GO:0002281IEA-macrophage activation involved in immune response-
GO:0006968TAS-cellular defense response9490415
GO:0007165TAS-signal transduction9490415
GO:0007229IEA-integrin-mediated signaling pathway-
GO:0035556TAS-intracellular signal transduction9490415
GO:0043312TAS-neutrophil degranulation-
GO:0045087TAS-innate immune response-
GO:0050776TAS-regulation of immune response-
GO:2001204IEA-regulation of osteoclast development-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
KIR2DS2TYROBP1100089490415 11169398 Affinity Capture-Western
KIR2DS2TYROBP1131559490415 11169398 Affinity Capture-Western
ZAP70TYROBP1133679490415 Protein-peptide
ZAP70TYROBP1131559490415 Protein-peptide
NCR2TYROBP11482710049942 Affinity Capture-Western
NCR2TYROBP11315510049942 Affinity Capture-Western
SIRPB1TYROBP11560910604985 10940905 Affinity Capture-Western
SIRPB1TYROBP11315510604985 10940905 Affinity Capture-Western
TREM1TYROBP11992610799849 Affinity Capture-Western
TREM1TYROBP11315510799849 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
TYROBPrs3817624 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1277211
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-061130-2'