AutismKB 2.0

Annotation Details for UBE2L3


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Basic Information Top
Gene Symbol:UBE2L3 ( E2-F1,L-UBC,UBCH7,UbcM4 )
Gene Full Name: ubiquitin-conjugating enzyme E2L 3
Band: 22q11.21
Quick LinksEntrez ID:7332; OMIM: 603721; Uniprot ID:UB2L3_HUMAN; ENSEMBL ID: ENSG00000185651; HGNC ID: 12488
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000151TAS-ubiquitin ligase complex8563171
GO:0005634IDA-nucleus11278816
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm9990509
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0003713IDA-transcription coactivator activity15367689
GO:0003723IDA-RNA binding22658674
GO:0004842IDA-ubiquitin-protein transferase activity14765125
GO:0004842IMP-ubiquitin-protein transferase activity10888878
GO:0004842TAS-ubiquitin-protein transferase activity8563171
GO:0005515IPI-protein binding9990509
GO:0005524IEA-ATP binding-
GO:0019899TAS-enzyme binding8563171
GO:0031625IPI-ubiquitin protein ligase binding11278816
GO:0061631IDA-ubiquitin conjugating enzyme activity20061386
GO:0097027IGI-ubiquitin-protein transferase activator activity12628165
GO ID Evidence Qualifier GO_term References
GO:0000209IDA-protein polyubiquitination10888878
GO:0006351IEA-transcription, DNA-templated-
GO:0006355IDA-regulation of transcription, DNA-templated17003263
GO:0006355IMP-regulation of transcription, DNA-templated15367689
GO:0006464TAS-cellular protein modification process8576257
GO:0006511TAS-ubiquitin-dependent protein catabolic process8563171
GO:0008283IMP-cell proliferation18946090
GO:0016567IDA-protein ubiquitination9990509
GO:0016567TAS-protein ubiquitination-
GO:0031398IGI-positive regulation of protein ubiquitination12628165
GO:0044770IMP-cell cycle phase transition18946090
GO:0051443IGI-positive regulation of ubiquitin-protein transferase activity12628165
GO:0070979IDA-protein K11-linked ubiquitination20061386
GO:0071383IMP-cellular response to steroid hormone stimulus15367689
GO:0071385IDA-cellular response to glucocorticoid stimulus17003263
GO:1903955IMP-positive regulation of protein targeting to mitochondrion24270810
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
UBE2L3BIRC210682612525502 Affinity Capture-Western
UBE2L3BIRC211318012525502 Affinity Capture-Western
UBE2L3BIRC311318012525502 Affinity Capture-Western
UBE2L3BIRC310682712525502 Affinity Capture-Western
UBE2L3XIAP11318012525502 Affinity Capture-Western
UBE2L3XIAP10682812525502 Affinity Capture-Western
UBE2L3BRCA111318012732733 Reconstituted Complex
UBE2L3BRCA110714012732733 Reconstituted Complex
UBE2L3CBL11318010531381 10966114 12234920 16735510 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
UBE2L3CBL10731510531381 10966114 12234920 16735510 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
UBE2L3MID111318019549727 Two-hybrid
UBE2L3MID111042719549727 Two-hybrid
UBE2L3MYC11318011431533 Affinity Capture-Western
UBE2L3MYC11069411431533 Affinity Capture-Western
UBE2L3NEDD41131809990509 17719543 18498246 Biochemical Activity; Reconstituted Complex
UBE2L3NEDD41108119990509 17719543 18498246 Biochemical Activity; Reconstituted Complex
UBE2L3PARK211110511431533 Affinity Capture-Western
UBE2L3PARK211318011431533 Affinity Capture-Western
UBE2L3POLR2A11318017996703 Reconstituted Complex
UBE2L3POLR2A11142617996703 Reconstituted Complex
UBE2L3PTEN11318012620973 Affinity Capture-Western
UBE2L3PTEN11170012620973 Affinity Capture-Western
UBE2L3AURKA11266617353931 Affinity Capture-MS
UBE2L3AURKA11318017353931 Affinity Capture-MS
UBE3AUBE2L31131858576257 9990509 10558980 11431533 Affinity Capture-Western; Biochemical Activity; Co-crystal Structure
UBE3AUBE2L31131808576257 9990509 10558980 11431533 Affinity Capture-Western; Biochemical Activity; Co-crystal Structure
ARIH1UBE2L311318010521492 11278816 14623119 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ARIH1UBE2L311734810521492 11278816 14623119 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CUL9UBE2L311673610521492 Two-hybrid
CUL9UBE2L311318010521492 Two-hybrid
RNF19AUBE2L311318011237715 Affinity Capture-Western
RNF19AUBE2L311740511237715 Affinity Capture-Western
UBOX5UBE2L311318011274149 19549727 Reconstituted Complex; Two-hybrid
UBOX5UBE2L311655411274149 19549727 Reconstituted Complex; Two-hybrid
EIF4E2UBE2L311318014623119 Affinity Capture-Western
EIF4E2UBE2L311485614623119 Affinity Capture-Western
RNF216UBE2L311318015107846 Affinity Capture-Western
RNF216UBE2L311998115107846 Affinity Capture-Western
ARIH2UBE2L311569416118314 16169070 19549727 Reconstituted Complex; Two-hybrid
ARIH2UBE2L311318016118314 16169070 19549727 Reconstituted Complex; Two-hybrid
RNF144BUBE2L312910616427630 19549727 Affinity Capture-Western; Two-hybrid
RNF144BUBE2L311318016427630 19549727 Affinity Capture-Western; Two-hybrid
RNF19BUBE2L312606516709802 Affinity Capture-Western
RNF19BUBE2L311318016709802 Affinity Capture-Western
UBASH3AUBE2L311974817588522 FRET
UBASH3AUBE2L311318017588522 FRET
WWP2UBE2L311318017719543 Reconstituted Complex
WWP2UBE2L311624417719543 Reconstituted Complex
SMURF2UBE2L311318017719543 Reconstituted Complex
SMURF2UBE2L312226517719543 Reconstituted Complex
ITCHUBE2L312374717719543 Reconstituted Complex
ITCHUBE2L311318017719543 Reconstituted Complex
RBCK1UBE2L311586219549727 Two-hybrid
RBCK1UBE2L311318019549727 Two-hybrid
RNF113BUBE2L312660319549727 Two-hybrid
RNF113BUBE2L311318019549727 Two-hybrid
DTX3UBE2L312820319549727 Two-hybrid
DTX3UBE2L311318019549727 Two-hybrid
CBLCUBE2L311715619549727 Two-hybrid
CBLCUBE2L311318019549727 Two-hybrid
RNF125UBE2L312028119549727 Two-hybrid
RNF125UBE2L311318019549727 Two-hybrid
TRIM39UBE2L311318019549727 Two-hybrid
TRIM39UBE2L312117019549727 Two-hybrid
MKRN3UBE2L311318019549727 Two-hybrid
MKRN3UBE2L311347919549727 Two-hybrid
TRAF7UBE2L311318019549727 Two-hybrid
TRAF7UBE2L312396419549727 Two-hybrid
RNF144AUBE2L311318019549727 Two-hybrid
RNF144AUBE2L311512519549727 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
ARIH1UBE2L326217812234920 An unspecified isoform of UbcH7 interacts with Ari-1. This interaction was modeled on a demonstrated interaction between human UbcH7 and Drosophila melanogaster Ari-1.
ARIH2UBE2L326217912234920 An unspecified isoform of UbcH7 interacts with hAri-2.
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
UBE2L3rs2266959 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
UBE2L3rs1034329, rs140498 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:109240
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-2977'