AutismKB 2.0

Annotation Details for UBE2N


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Basic Information Top
Gene Symbol:UBE2N ( MGC131857,MGC8489,UBC13,UbcH-ben )
Gene Full Name: ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)
Band: 12q22
Quick LinksEntrez ID:7334; OMIM: 603679; Uniprot ID:UBE2N_HUMAN; ENSEMBL ID: ENSG00000177889; HGNC ID: 12492
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000151IDA-ubiquitin ligase complex16307917
GO:0001650IDA-fibrillar center-
GO:0005634IDA-nucleus16129784
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm19340006
GO:0005737TAS-cytoplasm16129784
GO:0005829TAS-cytosol-
GO:0031372IDA-UBC13-MMS2 complex16129784
GO:0035370IDA-UBC13-UEV1A complex16307917
GO:0043234IDA-protein complex22797923
GO:0070062IDA-extracellular exosome20458337
GO ID Evidence Qualifier GO_term References
GO:0003723IDA-RNA binding22681889
GO:0004842IDA-ubiquitin-protein transferase activity20061386
GO:0005515IPI-protein binding11473255
GO:0005524IEA-ATP binding-
GO:0031625IBA-ubiquitin protein ligase binding-
GO:0043130IDA-ubiquitin binding16122702
GO:0061630IBA-ubiquitin protein ligase activity-
GO ID Evidence Qualifier GO_term References
GO:0000187TAS-activation of MAPK activity-
GO:0000724IMP-double-strand break repair via homologous recombination17349954
GO:0000729IMP-DNA double-strand break processing17349954
GO:0002223TAS-stimulatory C-type lectin receptor signaling pathway-
GO:0006282TAS-regulation of DNA repair10089880
GO:0006301IMP-postreplication repair17349954
GO:0006303TAS-double-strand break repair via nonhomologous end joining-
GO:0006464TAS-cellular protein modification process8902611
GO:0006508TAS-proteolysis8902611
GO:0007254TAS-JNK cascade-
GO:0016567IMP-protein ubiquitination17349954
GO:0016567TAS-protein ubiquitination16129784
GO:0016574IMP-histone ubiquitination17349954
GO:0031058IMP-positive regulation of histone modification17349954
GO:0033182IMP-regulation of histone ubiquitination17349954
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0043123IMP-positive regulation of I-kappaB kinase/NF-kappaB signaling16129784
GO:0043123TAS-positive regulation of I-kappaB kinase/NF-kappaB signaling-
GO:0045739IMP-positive regulation of DNA repair16129784
GO:0050852IMP-T cell receptor signaling pathway15125833
GO:0050852TAS-T cell receptor signaling pathway-
GO:0051092IMP-positive regulation of NF-kappaB transcription factor activity14695475
GO:0051092TAS-positive regulation of NF-kappaB transcription factor activity-
GO:0051443IMP-positive regulation of ubiquitin-protein transferase activity17349954
GO:0070423TAS-nucleotide-binding oligomerization domain containing signaling pathway-
GO:0070534IDA-protein K63-linked ubiquitination16307917
GO:0070534IMP-protein K63-linked ubiquitination25936802
GO:0070911TAS-global genome nucleotide-excision repair-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
UBE2NAMFR11318219549727 19690564 Two-hybrid
UBE2NAMFR10676419549727 19690564 Two-hybrid
UBE2NBIRC310682719690564 Two-hybrid
UBE2NBIRC311318219690564 Two-hybrid
UBE2NXIAP10682819549727 Two-hybrid
UBE2NXIAP11318219549727 Two-hybrid
UBE2NCHUK11318211057907 Biochemical Activity
UBE2NCHUK10756911057907 Biochemical Activity
UBE2NDTX111318219690564 Two-hybrid
UBE2NDTX110817319690564 Two-hybrid
UBE2NHSP90AA111318216307917 Reconstituted Complex
UBE2NHSP90AA110955216307917 Reconstituted Complex
UBE2NIL1B11318211057907 Phenotypic Suppression
UBE2NIL1B10976911057907 Phenotypic Suppression
UBE2NMID111318219549727 Two-hybrid
UBE2NMID111042719549727 Two-hybrid
UBE2NNFX111086519690564 Two-hybrid
UBE2NNFX111318219690564 Two-hybrid
UBE2NCNOT411318219690564 Two-hybrid
UBE2NCNOT411091219690564 Two-hybrid
UBE2NSIAH111318219549727 Two-hybrid
UBE2NSIAH111237219549727 Two-hybrid
UBE2NHLTF11248018316726 Affinity Capture-Western; Reconstituted Complex
UBE2NHLTF11318218316726 Affinity Capture-Western; Reconstituted Complex
UBE2NAURKA11266612881723 17060341 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
UBE2NAURKA11318212881723 17060341 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
UBE2NCNTN211318217942533 Affinity Capture-Western
UBE2NCNTN211276317942533 Affinity Capture-Western
UBE2NTNF11318211057907 Phenotypic Suppression
UBE2NTNF11297911057907 Phenotypic Suppression
UBE2NTP5311301017000756 Affinity Capture-Western; Reconstituted Complex
UBE2NTP5311318217000756 Affinity Capture-Western; Reconstituted Complex
UBE2NTRAF211318211057907 Phenotypic Suppression; Reconstituted Complex
UBE2NTRAF211303811057907 Phenotypic Suppression; Reconstituted Complex
UBE2NTRAF611304111057907 19549727 Phenotypic Suppression; Reconstituted Complex; Two-hybrid
UBE2NTRAF611318211057907 19549727 Phenotypic Suppression; Reconstituted Complex; Two-hybrid
UBE2V1UBE2N11318211057907 16129784 16307917 Co-purification; Reconstituted Complex; Two-hybrid
UBE2V1UBE2N11318311057907 16129784 16307917 Co-purification; Reconstituted Complex; Two-hybrid
RNF128UBE2N11318212705856 Reconstituted Complex
RNF128UBE2N12273112705856 Reconstituted Complex
TMEM189UBE2N13232016129784 Reconstituted Complex; Two-hybrid
TMEM189UBE2N11318216129784 Reconstituted Complex; Two-hybrid
UBE2V2UBE2N11318216129784 Reconstituted Complex; Two-hybrid
UBE2V2UBE2N11318416129784 Reconstituted Complex; Two-hybrid
STUB1UBE2N11556316307917 Reconstituted Complex
STUB1UBE2N11318216307917 Reconstituted Complex
TRIM32UBE2N11318217994549 19549727 19690564 Affinity Capture-Western; Two-hybrid
TRIM32UBE2N11660817994549 19549727 19690564 Affinity Capture-Western; Two-hybrid
RBCK1UBE2N11586219549727 Two-hybrid
RBCK1UBE2N11318219549727 Two-hybrid
BIRC8UBE2N11318219549727 Two-hybrid
BIRC8UBE2N12518619549727 Two-hybrid
RNF11UBE2N11318219549727 19690564 Two-hybrid
RNF11UBE2N11794119549727 19690564 Two-hybrid
RC3H2UBE2N11318219549727 Two-hybrid
RC3H2UBE2N12002919549727 Two-hybrid
MARCH5UBE2N11318219549727 Two-hybrid
MARCH5UBE2N12010519549727 Two-hybrid
RNF125UBE2N11318219549727 Two-hybrid
RNF125UBE2N12028119549727 Two-hybrid
RFWD3UBE2N11318219549727 Two-hybrid
RFWD3UBE2N12046019549727 Two-hybrid
CHFRUBE2N11318219549727 Two-hybrid
CHFRUBE2N12086119549727 Two-hybrid
MARCH7UBE2N11318219549727 Two-hybrid
MARCH7UBE2N12231919549727 Two-hybrid
MKRN3UBE2N11318219549727 Two-hybrid
MKRN3UBE2N11347919549727 Two-hybrid
TRIM25UBE2N11350019549727 Two-hybrid
TRIM25UBE2N11318219549727 Two-hybrid
ZNRF1UBE2N11318219549727 19690564 Two-hybrid
ZNRF1UBE2N12437119549727 19690564 Two-hybrid
TRIM5UBE2N11318219549727 Two-hybrid
TRIM5UBE2N12449119549727 Two-hybrid
RNF8UBE2N11449219549727 Two-hybrid
RNF8UBE2N11318219549727 Two-hybrid
LRSAM1UBE2N11318219549727 19690564 Two-hybrid
LRSAM1UBE2N12475419549727 19690564 Two-hybrid
DZIP3UBE2N11318219549727 Two-hybrid
DZIP3UBE2N11502119549727 Two-hybrid
OTUB1UBE2N11318219615732 Affinity Capture-MS
OTUB1UBE2N12075119615732 Affinity Capture-MS
STAMBPL1UBE2N11318219615732 Affinity Capture-MS
STAMBPL1UBE2N12161419615732 Affinity Capture-MS
TOPORSUBE2N11318219690564 Two-hybrid
TOPORSUBE2N11550519690564 Two-hybrid
MID2UBE2N11623119690564 Two-hybrid
MID2UBE2N11318219690564 Two-hybrid
RNF13UBE2N11647019690564 Two-hybrid
RNF13UBE2N11318219690564 Two-hybrid
ZNRF4UBE2N12711619690564 Two-hybrid
ZNRF4UBE2N11318219690564 Two-hybrid
SH3RF2UBE2N12751719690564 Two-hybrid
SH3RF2UBE2N11318219690564 Two-hybrid
RNF152UBE2N12864719690564 Two-hybrid
RNF152UBE2N11318219690564 Two-hybrid
RNF182UBE2N12874519690564 Two-hybrid
RNF182UBE2N11318219690564 Two-hybrid
ZNRF2UBE2N12882519690564 Two-hybrid
ZNRF2UBE2N11318219690564 Two-hybrid
RNF167UBE2N11318219690564 Two-hybrid
RNF167UBE2N11747719690564 Two-hybrid
RNF165UBE2N13896619690564 Two-hybrid
RNF165UBE2N11318219690564 Two-hybrid
RNF43UBE2N11318219690564 Two-hybrid
RNF43UBE2N12024119690564 Two-hybrid
RNF130UBE2N11318219690564 Two-hybrid
RNF130UBE2N12092819690564 Two-hybrid
MIB1UBE2N11318219690564 Two-hybrid
MIB1UBE2N12159319690564 Two-hybrid
RNF103UBE2N11318219690564 Two-hybrid
RNF103UBE2N11360119690564 Two-hybrid
ZNRF3UBE2N11318219690564 Two-hybrid
ZNRF3UBE2N12390519690564 Two-hybrid
NEURLUBE2N11459519690564 Two-hybrid
NEURLUBE2N11318219690564 Two-hybrid
CADPS2UBE2N11318219690564 Two-hybrid
CADPS2UBE2N12505119690564 Two-hybrid
PJA2UBE2N11520019690564 Two-hybrid
PJA2UBE2N11318219690564 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1934835
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-1291'