AutismKB 2.0

Annotation Details for UBE3A


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Basic Information Top
Gene Symbol:UBE3A ( ANCR,AS,E6-AP,EPVE6AP,FLJ26981,HPVE6A )
Gene Full Name: ubiquitin protein ligase E3A
Band: 15q11.2
Quick LinksEntrez ID:7337; OMIM: 601623; Uniprot ID:UBE3A_HUMAN; ENSEMBL ID: ENSG00000114062; HGNC ID: 12496
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000502IEA-proteasome complex-
GO:0005634IEA-nucleus-
GO:0005829IEA-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0003713IEA-transcription coactivator activity-
GO:0004842IDA-ubiquitin-protein transferase activity12890688
GO:0005515IPI-protein binding7624774
GO:0046872IEA-metal ion binding-
GO:0061630IMP-ubiquitin protein ligase activity7708685
GO ID Evidence Qualifier GO_term References
GO:0001541IEA-ovarian follicle development-
GO:0006508TAS-proteolysis8221889
GO:0006511IEA-ubiquitin-dependent protein catabolic process-
GO:0007420TAS-brain development8988171
GO:0014068IEA-positive regulation of phosphatidylinositol 3-kinase signaling-
GO:0016032IEA-viral process-
GO:0030521IEA-androgen receptor signaling pathway-
GO:0031398IDA-positive regulation of protein ubiquitination17108031
GO:0035037IEA-sperm entry-
GO:0042752IMP-regulation of circadian rhythm24728990
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0051865IDA-protein autoubiquitination24105792
GO:0060736IEA-prostate gland growth-
GO:0070936IDA-protein K48-linked ubiquitination12890688
GO:2000058IMP-regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process24728990
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
UBE3ABARD110705612890688 Reconstituted Complex
UBE3ABARD111318512890688 Reconstituted Complex
UBE3ABLK10710910449731 Reconstituted Complex
UBE3ABLK11318510449731 Reconstituted Complex
UBE3ABRCA111318512890688 Reconstituted Complex
UBE3ABRCA110714012890688 Reconstituted Complex
UBE3AESR111318516314411 Affinity Capture-Western
UBE3AESR110840316314411 Affinity Capture-Western
UBE3AESR211318517962381 Affinity Capture-Western
UBE3AESR210840417962381 Affinity Capture-Western
UBE3ALCK11318510449731 Reconstituted Complex; Two-hybrid
UBE3ALCK11012410449731 Reconstituted Complex; Two-hybrid
UBE3AMCM71103449852095 Affinity Capture-Western; Reconstituted Complex
UBE3AMCM71131859852095 Affinity Capture-Western; Reconstituted Complex
UBE3APGR1112609891052 Reconstituted Complex; Two-hybrid
UBE3APGR1131859891052 Reconstituted Complex; Two-hybrid
UBE3ATSC211310015175323 18298802 Affinity Capture-Western; Reconstituted Complex
UBE3ATSC211318515175323 18298802 Affinity Capture-Western; Reconstituted Complex
UBE3AUBE2D11131858576257 10066826 Biochemical Activity
UBE3AUBE2D11131698576257 10066826 Biochemical Activity
UBE3AUBE2D21131859182527 9990509 Biochemical Activity; Reconstituted Complex; Two-hybrid
UBE3AUBE2D21131709182527 9990509 Biochemical Activity; Reconstituted Complex; Two-hybrid
UBE3AUBE2D31131859990509 Biochemical Activity
UBE3AUBE2D31131719990509 Biochemical Activity
UBE3AUBE2L31131858576257 9990509 10558980 11431533 Affinity Capture-Western; Biochemical Activity; Co-crystal Structure
UBE3AUBE2L31131808576257 9990509 10558980 11431533 Affinity Capture-Western; Biochemical Activity; Co-crystal Structure
UBQLN2UBE3A11900610983987 Affinity Capture-Western; Co-fractionation; Two-hybrid
UBQLN2UBE3A11318510983987 Affinity Capture-Western; Co-fractionation; Two-hybrid
UBQLN1UBE3A11900710983987 Affinity Capture-Western; Two-hybrid
UBQLN1UBE3A11318510983987 Affinity Capture-Western; Two-hybrid
BPY2UBE3A11453912207887 Affinity Capture-Western; Two-hybrid
BPY2UBE3A11318512207887 Affinity Capture-Western; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:105098
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-041114-190'