Gene Symbol:	UCHL1 ( PARK5,PGP 9.5,PGP9.5,PGP95,Uch-L1 )
Gene Full Name:	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Band:	4p13
Quick Links	Entrez ID:7345; OMIM: 191342; Uniprot ID:UCHL1_HUMAN; ENSEMBL ID: ENSG00000154277; HGNC ID: 12513
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005654	IDA	-	nucleoplasm	-
GO:0005737	IDA	-	cytoplasm	19477270
GO:0005737	ISS	-	cytoplasm	-
GO:0005737	TAS	-	cytoplasm	16130169
GO:0005789	IEA	-	endoplasmic reticulum membrane	-
GO:0005829	IDA	-	cytosol	-
GO:0005829	TAS	-	cytosol	-
GO:0005886	IDA	colocalizes_with	plasma membrane	19477270
GO:0043025	IEA	-	neuronal cell body	-
GO:0043209	IEA	-	myelin sheath	-
GO:0044306	IEA	-	neuron projection terminus	-
GO:0070062	IDA	-	extracellular exosome	23376485
GO:1904115	IEA	-	axon cytoplasm	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0004197	IDA	-	cysteine-type endopeptidase activity	8639624
GO:0004843	IBA	-	thiol-dependent ubiquitin-specific protease activity	-
GO:0005515	IPI	-	protein binding	12082530
GO:0008242	IDA	-	omega peptidase activity	9521656
GO:0016874	IEA	-	ligase activity	-
GO:0031625	IPI	-	ubiquitin protein ligase binding	19725078
GO:0031694	IPI	-	alpha-2A adrenergic receptor binding	19477270
GO:0036459	TAS	-	thiol-dependent ubiquitinyl hydrolase activity	-
GO:0043130	IDA	-	ubiquitin binding	9521656

GO ID	Evidence	Qualifier	GO_term	References
GO:0002931	IEA	-	response to ischemia	-
GO:0007412	IEA	-	axon target recognition	-
GO:0007628	IEA	-	adult walking behavior	-
GO:0008283	IEA	-	cell proliferation	-
GO:0016241	TAS	-	regulation of macroautophagy	24879150
GO:0016579	IDA	-	protein deubiquitination	9521656
GO:0016579	TAS	-	protein deubiquitination	-
GO:0019233	IEA	-	sensory perception of pain	-
GO:0019896	IEA	-	axonal transport of mitochondrion	-
GO:0042755	IEA	-	eating behavior	-
GO:0043161	NAS	-	proteasome-mediated ubiquitin-dependent protein catabolic process	24252804
GO:0043407	IDA	-	negative regulation of MAP kinase activity	19477270
GO:0048747	IEA	-	muscle fiber development	-
GO:0050905	IEA	-	neuromuscular process	-

Gene Symbol	Interactant	Interaction ID	References	Description
UCHL1	CDKN1B	113192	12082530	Affinity Capture-Western
UCHL1	CDKN1B	107461	12082530	Affinity Capture-Western
UCHL1	EGFR	108276	20029029	PCA
UCHL1	EGFR	113192	20029029	PCA
UCHL1	KRT4	113192	19615732	Affinity Capture-MS
UCHL1	KRT4	110049	19615732	Affinity Capture-MS
UCHL1	KRT17	113192	19615732	Affinity Capture-MS
UCHL1	KRT17	110070	19615732	Affinity Capture-MS
UCHL1	NEDD8	113192	16169070	Two-hybrid
UCHL1	NEDD8	110815	16169070	Two-hybrid
UCHL1	TP53	113192	18666234	Affinity Capture-Western
UCHL1	TP53	113010	18666234	Affinity Capture-Western
UCHL1	UBC	113192	15228595 16169070	Affinity Capture-Western; Two-hybrid
UCHL1	UBC	113164	15228595 16169070	Affinity Capture-Western; Two-hybrid
UCHL1	UBE2I	113192	12082530	Two-hybrid
UCHL1	UBE2I	113177	12082530	Two-hybrid
COPS5	UCHL1	113192	12082530	Affinity Capture-Western; Two-hybrid
COPS5	UCHL1	116183	12082530	Affinity Capture-Western; Two-hybrid
RANBP9	UCHL1	113192	12082530	Two-hybrid
RANBP9	UCHL1	115359	12082530	Two-hybrid
CBX1	UCHL1	113192	16169070	Two-hybrid
CBX1	UCHL1	116151	16169070	Two-hybrid
USP21	UCHL1	113192	19615732	Affinity Capture-MS
USP21	UCHL1	117950	19615732	Affinity Capture-MS
CCDC14	UCHL1	113192	19615732	Affinity Capture-MS
CCDC14	UCHL1	122281	19615732	Affinity Capture-MS

AutismKB 2.0

Annotation Details for UCHL1