AutismKB 2.0

Annotation Details for UCHL1


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Basic Information Top
Gene Symbol:UCHL1 ( PARK5,PGP 9.5,PGP9.5,PGP95,Uch-L1 )
Gene Full Name: ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Band: 4p13
Quick LinksEntrez ID:7345; OMIM: 191342; Uniprot ID:UCHL1_HUMAN; ENSEMBL ID: ENSG00000154277; HGNC ID: 12513
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654IDA-nucleoplasm-
GO:0005737IDA-cytoplasm19477270
GO:0005737ISS-cytoplasm-
GO:0005737TAS-cytoplasm16130169
GO:0005789IEA-endoplasmic reticulum membrane-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005886IDAcolocalizes_withplasma membrane19477270
GO:0043025IEA-neuronal cell body-
GO:0043209IEA-myelin sheath-
GO:0044306IEA-neuron projection terminus-
GO:0070062IDA-extracellular exosome23376485
GO:1904115IEA-axon cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0004197IDA-cysteine-type endopeptidase activity8639624
GO:0004843IBA-thiol-dependent ubiquitin-specific protease activity-
GO:0005515IPI-protein binding12082530
GO:0008242IDA-omega peptidase activity9521656
GO:0016874IEA-ligase activity-
GO:0031625IPI-ubiquitin protein ligase binding19725078
GO:0031694IPI-alpha-2A adrenergic receptor binding19477270
GO:0036459TAS-thiol-dependent ubiquitinyl hydrolase activity-
GO:0043130IDA-ubiquitin binding9521656
GO ID Evidence Qualifier GO_term References
GO:0002931IEA-response to ischemia-
GO:0007412IEA-axon target recognition-
GO:0007628IEA-adult walking behavior-
GO:0008283IEA-cell proliferation-
GO:0016241TAS-regulation of macroautophagy24879150
GO:0016579IDA-protein deubiquitination9521656
GO:0016579TAS-protein deubiquitination-
GO:0019233IEA-sensory perception of pain-
GO:0019896IEA-axonal transport of mitochondrion-
GO:0042755IEA-eating behavior-
GO:0043161NAS-proteasome-mediated ubiquitin-dependent protein catabolic process24252804
GO:0043407IDA-negative regulation of MAP kinase activity19477270
GO:0048747IEA-muscle fiber development-
GO:0050905IEA-neuromuscular process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
UCHL1CDKN1B11319212082530 Affinity Capture-Western
UCHL1CDKN1B10746112082530 Affinity Capture-Western
UCHL1EGFR10827620029029 PCA
UCHL1EGFR11319220029029 PCA
UCHL1KRT411319219615732 Affinity Capture-MS
UCHL1KRT411004919615732 Affinity Capture-MS
UCHL1KRT1711319219615732 Affinity Capture-MS
UCHL1KRT1711007019615732 Affinity Capture-MS
UCHL1NEDD811319216169070 Two-hybrid
UCHL1NEDD811081516169070 Two-hybrid
UCHL1TP5311319218666234 Affinity Capture-Western
UCHL1TP5311301018666234 Affinity Capture-Western
UCHL1UBC11319215228595 16169070 Affinity Capture-Western; Two-hybrid
UCHL1UBC11316415228595 16169070 Affinity Capture-Western; Two-hybrid
UCHL1UBE2I11319212082530 Two-hybrid
UCHL1UBE2I11317712082530 Two-hybrid
COPS5UCHL111319212082530 Affinity Capture-Western; Two-hybrid
COPS5UCHL111618312082530 Affinity Capture-Western; Two-hybrid
RANBP9UCHL111319212082530 Two-hybrid
RANBP9UCHL111535912082530 Two-hybrid
CBX1UCHL111319216169070 Two-hybrid
CBX1UCHL111615116169070 Two-hybrid
USP21UCHL111319219615732 Affinity Capture-MS
USP21UCHL111795019615732 Affinity Capture-MS
CCDC14UCHL111319219615732 Affinity Capture-MS
CCDC14UCHL112228119615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
UCHL1rs5030732 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
UCHL1967495, rs10517002, rs2060915, rs3775256, rs3775257, rs4861387, rs5030732, rs6847225 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:103149
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-3844'