AutismKB 2.0

Annotation Details for VCL


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Basic Information Top
Gene Symbol:VCL ( CMD1W,CMH15,MVCL )
Gene Full Name: vinculin
Band: 10q22.2
Quick LinksEntrez ID:7414; OMIM: 193065; Uniprot ID:VINC_HUMAN; ENSEMBL ID: ENSG00000035403; HGNC ID: 12665
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0002102IEA-podosome-
GO:0005576TAS-extracellular region-
GO:0005829TAS-cytosol-
GO:0005856TAS-cytoskeleton16130169
GO:0005886IEA-plasma membrane-
GO:0005911ISS-cell-cell junction-
GO:0005912ISS-adherens junction-
GO:0005913IDA-cell-cell adherens junction20086044
GO:0005916IEA-fascia adherens-
GO:0005925IDA-focal adhesion20086044
GO:0005925ISS-focal adhesion-
GO:0030055NAS-cell-substrate junction2116004
GO:0034774TAS-secretory granule lumen-
GO:0035580TAS-specific granule lumen-
GO:0043034IDA-costamere9415431
GO:0043034ISS-costamere-
GO:0043234IDA-protein complex9700171
GO:0070062IDA-extracellular exosome19056867
GO:1903561IDA-extracellular vesicle24769233
GO:1904813TAS-ficolin-1-rich granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0002162IPI-dystroglycan binding18341635
GO:0003779IDA-actin binding16803572
GO:0003779IDANOTactin binding7816144
GO:0005198IEA-structural molecule activity-
GO:0005515IPI-protein binding9054445
GO:0008013ISS-beta-catenin binding20086044
GO:0031625IPI-ubiquitin protein ligase binding19725078
GO:0045294IPI-alpha-catenin binding9700171
GO:0045296IDA-cadherin binding25468996
GO:0045296ISS-cadherin binding20086044
GO ID Evidence Qualifier GO_term References
GO:0002009IMP-morphogenesis of an epithelium20086044
GO:0002576TAS-platelet degranulation-
GO:0006928TAS-movement of cell or subcellular component16130169
GO:0006936TAS-muscle contraction-
GO:0007155TAS-cell adhesion15501673
GO:0007160TAS-cell-matrix adhesion20086044
GO:0030032ISS-lamellipodium assembly-
GO:0030336TAS-negative regulation of cell migration15494027
GO:0034333IMP-adherens junction assembly20086044
GO:0034394IMP-protein localization to cell surface20086044
GO:0043297IMP-apical junction assembly9700171
GO:0043312TAS-neutrophil degranulation-
GO:0048675IEA-axon extension-
GO:0070527IMP-platelet aggregation23382103
GO:0090136IMP-epithelial cell-cell adhesion20086044
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
VCLCDH11132579405455 9535896 Affinity Capture-Western
VCLCDH11074349405455 9535896 Affinity Capture-Western
VCLCLTC1132578276759 Reconstituted Complex
VCLCLTC1076238276759 Reconstituted Complex
VCLCTNNA11078769700171 Reconstituted Complex
VCLCTNNA11132579700171 Reconstituted Complex
VCLCTNNB11132579405455 Affinity Capture-Western
VCLCTNNB11078809405455 Affinity Capture-Western
VCLGSN10918911577104 Affinity Capture-Western
VCLGSN11325711577104 Affinity Capture-Western
VCLNRAP11095110320340 Reconstituted Complex
VCLNRAP11325710320340 Reconstituted Complex
VCLPSME111169216169070 Two-hybrid
VCLPSME111325716169070 Two-hybrid
VCLPXN1117878922390 9054445 10330411 Reconstituted Complex
VCLPXN1132578922390 9054445 10330411 Reconstituted Complex
VCLTGFB1I11132579858471 Reconstituted Complex
VCLTGFB1I11128999858471 Reconstituted Complex
VCLTRIP611305616189514 Two-hybrid
VCLTRIP611325716189514 Two-hybrid
VCLVASP11325110882740 Affinity Capture-Western
VCLVASP11325710882740 Affinity Capture-Western
SORBS1VCL11325710085297 Affinity Capture-Western; Reconstituted Complex
SORBS1VCL11583110085297 Affinity Capture-Western; Reconstituted Complex
CORO2BVCL11566310224093 Affinity Capture-Western
CORO2BVCL11325710224093 Affinity Capture-Western
SORBS2VCL11325710521485 Reconstituted Complex
SORBS2VCL11404710521485 Reconstituted Complex
BCAR1VCL11325711577104 Affinity Capture-Western
BCAR1VCL11493411577104 Affinity Capture-Western
ABI2VCL11325716189514 Two-hybrid
ABI2VCL11545416189514 Two-hybrid
C19orf57VCL12259016189514 Two-hybrid
C19orf57VCL11325716189514 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
VCLVCL Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:98927
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050506-61'