AutismKB 2.0

Annotation Details for VCP


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:VCP ( IBMPFD,MGC131997,MGC148092,MGC8560,TERA,p97 )
Gene Full Name: valosin-containing protein
Band: 9p13.3
Quick LinksEntrez ID:7415; OMIM: 601023; Uniprot ID:TERA_HUMAN; ENSEMBL ID: ENSG00000165280; HGNC ID: 12666
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000502IDA-proteasome complex9452483
GO:0005576TAS-extracellular region-
GO:0005634IDA-nucleus10855792
GO:0005634TAS-nucleus16130169
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005783IDA-endoplasmic reticulum15215856
GO:0005789IDA-endoplasmic reticulum membrane17872946
GO:0005789TAS-endoplasmic reticulum membrane-
GO:0005811IDA-lipid particle23297223
GO:0005829IDA-cytosol10855792
GO:0005829TAS-cytosol16186510
GO:0034098ISS-VCP-NPL4-UFD1 AAA ATPase complex-
GO:0034098TAS-VCP-NPL4-UFD1 AAA ATPase complex16186510
GO:0034774TAS-secretory granule lumen-
GO:0035578TAS-azurophil granule lumen-
GO:0035861IDA-site of double-strand break22120668
GO:0036513IDA-Derlin-1 retrotranslocation complex15215856
GO:0043209IEA-myelin sheath-
GO:0043231ISS-intracellular membrane-bounded organelle-
GO:0048471IDA-perinuclear region of cytoplasm16275660
GO:0070062IDA-extracellular exosome19056867
GO:1904813TAS-ficolin-1-rich granule lumen-
GO:1904949IEA-ATPase complex-
GO:1990730ISS-VCP-NSFL1C complex-
GO ID Evidence Qualifier GO_term References
GO:0003723IDA-RNA binding22681889
GO:0005515IPI-protein binding9452483
GO:0005524IEA-ATP binding-
GO:0008289IEA-lipid binding-
GO:0016887IMP-ATPase activity25125609
GO:0016887TAS-ATPase activity15215856
GO:0019903IPI-protein phosphatase binding10364224
GO:0019904IPI-protein domain specific binding15362974
GO:0031593IDA-polyubiquitin binding11483959
GO:0031625IPI-ubiquitin protein ligase binding22590560
GO:0035800IDA-deubiquitinase activator activity22970133
GO:0036435IEA-K48-linked polyubiquitin binding-
GO:0042288IEA-MHC class I protein binding-
GO:0042802IPI-identical protein binding20512113
GO:0043531IEA-ADP binding-
GO:0044389IPI-ubiquitin-like protein ligase binding16186510
GO:1904288IPI-BAT3 complex binding21636303
GO:1990381IPI-ubiquitin-specific protease binding22590560
GO ID Evidence Qualifier GO_term References
GO:0006281NAS-DNA repair16140914
GO:0006302IDA-double-strand break repair10855792
GO:0006457TAS-protein folding-
GO:0006479TAS-protein methylation-
GO:0006734IMP-NADH metabolic process23498975
GO:0006888IEA-ER to Golgi vesicle-mediated transport-
GO:0006914IMP-autophagy20104022
GO:0006919ISS-activation of cysteine-type endopeptidase activity involved in apoptotic process-
GO:0006974IDA-cellular response to DNA damage stimulus16140914
GO:0010498IMP-proteasomal protein catabolic process26565908
GO:0010918IMP-positive regulation of mitochondrial membrane potential23498975
GO:0016567IDA-protein ubiquitination22120668
GO:0016567NAS-protein ubiquitination15215856
GO:0016567TAS-protein ubiquitination-
GO:0016579TAS-protein deubiquitination-
GO:0018279IMP-protein N-linked glycosylation via asparagine22607976
GO:0019079IMP-viral genome replication22379090
GO:0019985IMP-translesion synthesis23042605
GO:0030433IDA-ubiquitin-dependent ERAD pathway17872946
GO:0030433IMP-ubiquitin-dependent ERAD pathway22607976
GO:0030433TAS-ubiquitin-dependent ERAD pathway15215856
GO:0030968TAS-endoplasmic reticulum unfolded protein response15215856
GO:0030970IDA-retrograde protein transport, ER to cytosol15215856
GO:0030970IMP-retrograde protein transport, ER to cytosol25660456
GO:0031334IDA-positive regulation of protein complex assembly18775313
GO:0032436IDA-positive regulation of proteasomal ubiquitin-dependent protein catabolic process9452483
GO:0034214IEA-protein hexamerization-
GO:0036503IDA-ERAD pathway25088257
GO:0036503IMP-ERAD pathway20104022
GO:0042981TAS-regulation of apoptotic process16130169
GO:0043161IMP-proteasome-mediated ubiquitin-dependent protein catabolic process20104022
GO:0043161NAS-proteasome-mediated ubiquitin-dependent protein catabolic process15743842
GO:0043312TAS-neutrophil degranulation-
GO:0045184TAS-establishment of protein localization15215856
GO:0045732IDA-positive regulation of protein catabolic process11483959
GO:0046034IEA-ATP metabolic process-
GO:0051260IEA-protein homooligomerization-
GO:0055085TAS-transmembrane transport-
GO:0061857IMP-endoplasmic reticulum stress-induced pre-emptive quality control26565908
GO:0070842IEA-aggresome assembly-
GO:0070987TAS-error-free translesion synthesis-
GO:0071712IMP-ER-associated misfolded protein catabolic process24089527
GO:0072389IMP-flavin adenine dinucleotide catabolic process23498975
GO:0097352IMP-autophagosome maturation20104022
GO:1903006IDA-positive regulation of protein K63-linked deubiquitination22970133
GO:1903007IDA-positive regulation of Lys63-specific deubiquitinase activity22970133
GO:1903715IMP-regulation of aerobic respiration23498975
GO:1903862IMP-positive regulation of oxidative phosphorylation23498975
GO:2000158IEA-positive regulation of ubiquitin-specific protease activity-
GO:2001171IMP-positive regulation of ATP biosynthetic process23498975
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
VCPAMFR11325815331598 16186510 17681147 17872946 18835813 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
VCPAMFR10676415331598 16186510 17681147 17872946 18835813 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
VCPBRCA111325810855792 Affinity Capture-Western; Reconstituted Complex
VCPBRCA110714010855792 Affinity Capture-Western; Reconstituted Complex
VCPCASR11325816513638 Affinity Capture-Western
VCPCASR10729616513638 Affinity Capture-Western
VCPCD3D11325815331598 17872946 Affinity Capture-Western
VCPCD3D10735315331598 17872946 Affinity Capture-Western
VCPCFTR11325816621797 Affinity Capture-Western
VCPCFTR10750616621797 Affinity Capture-Western
VCPHLA-B11325817353931 Affinity Capture-MS
VCPHLA-B10935117353931 Affinity Capture-MS
VCPHSPA410954016621797 Affinity Capture-Western
VCPHSPA411325816621797 Affinity Capture-Western
VCPHSPA811325816621797 Affinity Capture-Western
VCPHSPA810954416621797 Affinity Capture-Western
VCPHSP90AA111325816621797 Affinity Capture-Western
VCPHSP90AA110955216621797 Affinity Capture-Western
VCPINSIG110985016168377 18835813 Affinity Capture-Western
VCPINSIG111325816168377 18835813 Affinity Capture-Western
VCPITGB110989415723043 Affinity Capture-Western
VCPITGB111325815723043 Affinity Capture-Western
VCPMCC11325817353931 Affinity Capture-MS
VCPMCC11033317353931 Affinity Capture-MS
VCPATXN311325812944474 14749733 18199748 Affinity Capture-Western; Reconstituted Complex
VCPATXN311043312944474 14749733 18199748 Affinity Capture-Western; Reconstituted Complex
VCPNFKBIA1108599452483 Affinity Capture-Western; Reconstituted Complex
VCPNFKBIA1132589452483 Affinity Capture-Western; Reconstituted Complex
VCPPPM1B11149017353931 Affinity Capture-MS
VCPPPM1B11325817353931 Affinity Capture-MS
VCPPSMC11132589452483 Affinity Capture-Western
VCPPSMC11116739452483 Affinity Capture-Western
VCPSGK111325817353931 Affinity Capture-MS
VCPSGK111234417353931 Affinity Capture-MS
VCPTRAF611304117353931 Affinity Capture-MS
VCPTRAF611325817353931 Affinity Capture-MS
VCPUBC11325815331598 18199748 Affinity Capture-Western
VCPUBC11316415331598 18199748 Affinity Capture-Western
VCPUFD1L11320017872946 18199748 Affinity Capture-Western
VCPUFD1L11325817872946 18199748 Affinity Capture-Western
TOMM34VCP11325811913976 Reconstituted Complex
TOMM34VCP11615311913976 Reconstituted Complex
VCPVCP11325812807884 16621797 17525332 Affinity Capture-Western; Co-fractionation
NSFL1CVCP12101412810701 Affinity Capture-Western; Reconstituted Complex
NSFL1CVCP11325812810701 Affinity Capture-Western; Reconstituted Complex
UBE4BVCP11556614749733 21282470 Affinity Capture-Western; Reconstituted Complex
UBE4BVCP11325814749733 21282470 Affinity Capture-Western; Reconstituted Complex
SELSVCP12093415215856 16289116 17872946 18199748 Affinity Capture-Western; Reconstituted Complex
SELSVCP11325815215856 16289116 17872946 18199748 Affinity Capture-Western; Reconstituted Complex
FBXO2VCP11762315723043 Affinity Capture-Western
FBXO2VCP11325815723043 Affinity Capture-Western
FBXO6VCP11765415723043 Affinity Capture-Western
FBXO6VCP11325815723043 Affinity Capture-Western
SRRM2VCP11707116159877 Affinity Capture-MS
SRRM2VCP11325816159877 Affinity Capture-MS
DERL2VCP11921616186509 Affinity Capture-Western
DERL2VCP11325816186509 Affinity Capture-Western
DERL1VCP12255916186509 16186510 16289116 17872946 18199748 Affinity Capture-Western; Reconstituted Complex
DERL1VCP11325816186509 16186510 16289116 17872946 18199748 Affinity Capture-Western; Reconstituted Complex
SYVN1VCP12408516186510 16289116 17872946 Affinity Capture-Western; Reconstituted Complex
SYVN1VCP11325816186510 16289116 17872946 Affinity Capture-Western; Reconstituted Complex
HERPUD1VCP11506016289116 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
HERPUD1VCP11325816289116 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
RNF19AVCP11325816513638 Affinity Capture-Western
RNF19AVCP11740516513638 Affinity Capture-Western
STUB1VCP11556316621797 Affinity Capture-Western
STUB1VCP11325816621797 Affinity Capture-Western
WDR8VCP11906817353931 Affinity Capture-MS
WDR8VCP11325817353931 Affinity Capture-MS
IKBKEVCP11500017353931 Affinity Capture-MS
IKBKEVCP11325817353931 Affinity Capture-MS
CHEK2VCP11636917525332 Affinity Capture-Western
CHEK2VCP11325817525332 Affinity Capture-Western
NPLOC4VCP11325817872946 18586029 Affinity Capture-Western
NPLOC4VCP12079817872946 18586029 Affinity Capture-Western
SVIPVCP11325817872946 Affinity Capture-Western; Co-fractionation
SVIPVCP12922217872946 Affinity Capture-Western; Co-fractionation
RNF103VCP11360118675248 Affinity Capture-Western
RNF103VCP11325818675248 Affinity Capture-Western
FAF2VCP11680618835813 Affinity Capture-Western
FAF2VCP11325818835813 Affinity Capture-Western
UBXN6VCP12326319174149 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
UBXN6VCP11325819174149 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
VCPIP1VCP12312519615732 Affinity Capture-MS
VCPIP1VCP11325819615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
VCPrs10972300 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
VCPrs2258240 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:99919
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-5408'