AutismKB 2.0

Annotation Details for VHL


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Basic Information Top
Gene Symbol:VHL ( HRCA1,RCA1,VHL1 )
Gene Full Name: von Hippel-Lindau tumor suppressor
Band: 3p25.3
Quick LinksEntrez ID:7428; OMIM: 608537; Uniprot ID:VHL_HUMAN; ENSEMBL ID: ENSG00000134086; HGNC ID: 12687
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634TAS-nucleus7604013
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005739NAS-mitochondrion12169691
GO:0005783NAS-endoplasmic reticulum12169691
GO:0005829TAS-cytosol-
GO:0016020IEA-membrane-
GO:0030891IBA-VCB complex-
GO ID Evidence Qualifier GO_term References
GO:0004842TAS-ubiquitin-protein transferase activity-
GO:0005515IPI-protein binding11292862
GO:0008134IPI-transcription factor binding11641274
GO:0019899IPI-enzyme binding11641274
GO:0061630IDA-ubiquitin protein ligase activity24899725
GO ID Evidence Qualifier GO_term References
GO:0000122TAS-negative regulation of transcription from RNA polymerase II promoter7660122
GO:0000902NAS-cell morphogenesis12169691
GO:0006355IMP-regulation of transcription, DNA-templated15824735
GO:0006508TAS-proteolysis10353251
GO:0008285IMP-negative regulation of cell proliferation23338840
GO:0010629IMP-negative regulation of gene expression23338840
GO:0016567IDA-protein ubiquitination24899725
GO:0016567IEA-protein ubiquitination-
GO:0016567IMP-protein ubiquitination12169691
GO:0016567TAS-protein ubiquitination-
GO:0043066NAS-negative regulation of apoptotic process12169691
GO:0043687TAS-post-translational protein modification-
GO:0045597NAS-positive regulation of cell differentiation12169691
GO:0045893IMP-positive regulation of transcription, DNA-templated17973242
GO:0046426IMP-negative regulation of JAK-STAT cascade23338840
GO:0050821NAS-protein stabilization12169691
GO:0061418TAS-regulation of transcription from RNA polymerase II promoter in response to hypoxia-
GO:0061428IDA-negative regulation of transcription from RNA polymerase II promoter in response to hypoxia11641274
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
VHLAPRT10684917353931 Affinity Capture-MS
VHLAPRT11326917353931 Affinity Capture-MS
VHLRHOC11326917353931 Affinity Capture-MS
VHLRHOC10688217353931 Affinity Capture-MS
VHLATM11326916678111 Affinity Capture-Western
VHLATM10696216678111 Affinity Capture-Western
VHLCDK211326917353931 Affinity Capture-MS
VHLCDK210745217353931 Affinity Capture-MS
VHLCDO111326917353931 Affinity Capture-MS
VHLCDO110746817353931 Affinity Capture-MS
VHLCNTF11326917353931 Affinity Capture-MS
VHLCNTF10767017353931 Affinity Capture-MS
VHLCSTB11326917353931 Affinity Capture-MS
VHLCSTB10785817353931 Affinity Capture-MS
VHLCSTF311326917353931 Affinity Capture-MS
VHLCSTF310786117353931 Affinity Capture-MS
VHLCYBA11326917200123 Affinity Capture-Western
VHLCYBA10791517200123 Affinity Capture-Western
VHLEP30011326916678111 Affinity Capture-Western
VHLEP30010834716678111 Affinity Capture-Western
VHLEPAS110834812604794 17967880 Affinity Capture-Western
VHLEPAS111326912604794 17967880 Affinity Capture-Western
VHLFLNA1132698674032 12169691 Two-hybrid
VHLFLNA1086058674032 12169691 Two-hybrid
VHLFN11086219651579 Affinity Capture-Western
VHLFN11132699651579 Affinity Capture-Western
VHLHAS111326917353931 Affinity Capture-MS
VHLHAS110928617353931 Affinity Capture-MS
VHLHDAC111326911641274 Reconstituted Complex
VHLHDAC110931511641274 Reconstituted Complex
VHLHDAC211326911641274 Reconstituted Complex
VHLHDAC210931611641274 Reconstituted Complex
VHLHIF1A10933810944113 11504942 11566883 11641274 11865071 12004076 12050673 12464182 12538644 12606543 12682018 12808024 12925778 14556007 14600153 14691445 15721254 15805242 16278378 16611863 17047048 17558023 17973296 17981124 18264140 18305400 18426857 18694926 18985005 Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Protein-peptide; Reconstituted Complex
VHLHIF1A11326910944113 11504942 11566883 11641274 11865071 12004076 12050673 12464182 12538644 12606543 12682018 12808024 12925778 14556007 14600153 14691445 15721254 15805242 16278378 16611863 17047048 17558023 17973296 17981124 18264140 18305400 18426857 18694926 18985005 Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Protein-peptide; Reconstituted Complex
VHLNR4A111326918305400 Affinity Capture-Western; Reconstituted Complex
VHLNR4A110940718305400 Affinity Capture-Western; Reconstituted Complex
VHLHNRNPA2B111326911517223 Affinity Capture-Western
VHLHNRNPA2B110942211517223 Affinity Capture-Western
VHLIARS11326917353931 Affinity Capture-MS
VHLIARS10960517353931 Affinity Capture-MS
VHLIMPDH210982817353931 Affinity Capture-MS
VHLIMPDH211326917353931 Affinity Capture-MS
VHLIREB211326915777842 Affinity Capture-Western
VHLIREB210986615777842 Affinity Capture-Western
VHLMCC11326917353931 Affinity Capture-MS
VHLMCC11033317353931 Affinity Capture-MS
VHLNEDD811326917353931 Affinity Capture-MS
VHLNEDD811081517353931 Affinity Capture-MS
VHLPCMT111326917353931 Affinity Capture-MS
VHLPCMT111114117353931 Affinity Capture-MS
VHLPFAS11326917353931 Affinity Capture-MS
VHLPFAS11122117353931 Affinity Capture-MS
VHLPIN111326917353931 Affinity Capture-MS
VHLPIN111131717353931 Affinity Capture-MS
VHLPOLR2A11326912604794 18285459 Affinity Capture-Western; Protein-peptide
VHLPOLR2A11142612604794 18285459 Affinity Capture-Western; Protein-peptide
VHLPOLR2G11143212912922 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
VHLPOLR2G11326912912922 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
VHLPPIB11326917353931 Affinity Capture-MS
VHLPPIB11147517353931 Affinity Capture-MS
VHLPSMB111326917353931 Affinity Capture-MS
VHLPSMB111166217353931 Affinity Capture-MS
VHLPSMB311326917353931 Affinity Capture-MS
VHLPSMB311166417353931 Affinity Capture-MS
VHLPSMC311326914556007 Affinity Capture-Western; Two-hybrid
VHLPSMC311167514556007 Affinity Capture-Western; Two-hybrid
VHLPSMD1311326917353931 Affinity Capture-MS
VHLPSMD1311169117353931 Affinity Capture-MS
VHLRIT111326919030229 Affinity Capture-Western
VHLRIT111194819030229 Affinity Capture-Western
VHLRPA311326917353931 Affinity Capture-MS
VHLRPA311203917353931 Affinity Capture-MS
VHLRPS911211717353931 Affinity Capture-MS
VHLRPS911326917353931 Affinity Capture-MS
VHLATXN211221817353931 Affinity Capture-MS
VHLATXN211326917353931 Affinity Capture-MS
VHLFSCN111250817353931 Affinity Capture-MS
VHLFSCN111326917353931 Affinity Capture-MS
VHLTARS11326917353931 Affinity Capture-MS
VHLTARS11276017353931 Affinity Capture-MS
VHLTCEB11127838674032 10587522 11739384 12004076 12604794 17353931 17558023 18305400 19030229 Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
VHLTCEB11132698674032 10587522 11739384 12004076 12604794 17353931 17558023 18305400 19030229 Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
VHLTCEB211326910587522 12004076 12048197 12604794 17353931 18173839 19030229 Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
VHLTCEB211278510587522 12004076 12048197 12604794 17353931 18173839 19030229 Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
VHLTCEB311326912048197 Affinity Capture-Western
VHLTCEB311278612048197 Affinity Capture-Western
VHLTGFB1I111326917353931 Affinity Capture-MS
VHLTGFB1I111289917353931 Affinity Capture-MS
VHLTP5311301016678111 Affinity Capture-Western; Reconstituted Complex
VHLTP5311326916678111 Affinity Capture-Western; Reconstituted Complex
VHLTPT111326917353931 Affinity Capture-MS
VHLTPT111303017353931 Affinity Capture-MS
VHLCCT311326911865071 Affinity Capture-Western
VHLCCT311305411865071 Affinity Capture-Western
VHLTXN11326917353931 Affinity Capture-MS
VHLTXN11314617353931 Affinity Capture-MS
VHLVBP11132698674032 12169691 Affinity Capture-Western; Two-hybrid
VHLVBP11132548674032 12169691 Affinity Capture-Western; Two-hybrid
CUL2VHL11403110587522 11384984 11865071 12048197 12604794 15966899 16611863 17353931 17439941 18173839 19030229 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
CUL2VHL11326910587522 11384984 11865071 12048197 12604794 15966899 16611863 17353931 17439941 18173839 19030229 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
CUL5VHL11374311384984 Reconstituted Complex
CUL5VHL11326911384984 Reconstituted Complex
HIF1ANVHL11326911641274 Reconstituted Complex
HIF1ANVHL12079411641274 Reconstituted Complex
HDAC3VHL11436811641274 Reconstituted Complex
HDAC3VHL11326911641274 Reconstituted Complex
USP33VHL11326911739384 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
USP33VHL11667111739384 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RBX1VHL11530112048197 12604794 16325183 17353931 Affinity Capture-MS; Affinity Capture-Western
RBX1VHL11326912048197 12604794 16325183 17353931 Affinity Capture-MS; Affinity Capture-Western
USP20VHL11326912056827 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
USP20VHL11607712056827 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
PHF17VHL11326912169691 14973063 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PHF17VHL12302912169691 14973063 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HIF3AVHL11326912538644 Affinity Capture-Western; Reconstituted Complex
HIF3AVHL12214312538644 Affinity Capture-Western; Reconstituted Complex
ZNF197VHL11326912682018 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ZNF197VHL11547012682018 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TRIM28VHL11545712682018 Reconstituted Complex
TRIM28VHL11326912682018 Reconstituted Complex
DNAJA3VHL11326915805242 Affinity Capture-Western; Reconstituted Complex
DNAJA3VHL11454715805242 Affinity Capture-Western; Reconstituted Complex
OSR1VHL12623416511565 Affinity Capture-Western
OSR1VHL11326916511565 Affinity Capture-Western
KAT2BVHL11326916678111 Affinity Capture-Western
KAT2BVHL11437516678111 Affinity Capture-Western
DGKZVHL11409517350623 Affinity Capture-Western; Co-localization
DGKZVHL11326917350623 Affinity Capture-Western; Co-localization
RASGRP1VHL11326917353931 Affinity Capture-MS
RASGRP1VHL11542917353931 Affinity Capture-MS
MYL12AVHL11587117353931 Affinity Capture-MS
MYL12AVHL11326917353931 Affinity Capture-MS
JMJD1CVHL11326917353931 Affinity Capture-MS
JMJD1CVHL12867717353931 Affinity Capture-MS
MOBKL3VHL11326917353931 Affinity Capture-MS
MOBKL3VHL11736917353931 Affinity Capture-MS
CHMP2BVHL11326917353931 Affinity Capture-MS
CHMP2BVHL11746217353931 Affinity Capture-MS
CCDC59VHL11326917353931 Affinity Capture-MS
CCDC59VHL11885017353931 Affinity Capture-MS
PKD1L3VHL11326917353931 Affinity Capture-MS
PKD1L3VHL13117317353931 Affinity Capture-MS
CAB39VHL11969617353931 Affinity Capture-MS
CAB39VHL11326917353931 Affinity Capture-MS
CCDC82VHL11326917353931 Affinity Capture-MS
CCDC82VHL12288017353931 Affinity Capture-MS
RAB1BVHL11326917353931 Affinity Capture-MS
RAB1BVHL12361917353931 Affinity Capture-MS
HIST1H2BCVHL11394317353931 Affinity Capture-MS
HIST1H2BCVHL11326917353931 Affinity Capture-MS
TAGLN2VHL11399517353931 Affinity Capture-MS
TAGLN2VHL11326917353931 Affinity Capture-MS
STK16VHL11414417353931 Affinity Capture-MS
STK16VHL11326917353931 Affinity Capture-MS
PAPSS2VHL11326917353931 Affinity Capture-MS
PAPSS2VHL11452117353931 Affinity Capture-MS
KNTC1VHL11508417353931 Affinity Capture-MS
KNTC1VHL11326917353931 Affinity Capture-MS
SAT2VHL11326917558023 Reconstituted Complex
SAT2VHL12519017558023 Reconstituted Complex
SAP130VHL12273518173839 Affinity Capture-Western
SAP130VHL11326918173839 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:103223
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070112-1042'