AutismKB 2.0

Annotation Details for EZR


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Basic Information Top
Gene Symbol:EZR ( CVIL,CVL,DKFZp762H157,FLJ26216,MGC1584,VIL2 )
Gene Full Name: ezrin
Band: 6q25.3
Quick LinksEntrez ID:7430; OMIM: 123900; Uniprot ID:EZRI_HUMAN; ENSEMBL ID: ENSG00000092820; HGNC ID: 12691
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001650IDA-fibrillar center-
GO:0001726IDA-ruffle9852149
GO:0001772IDA-immunological synapse20551903
GO:0001772IDAcolocalizes_withimmunological synapse17911601
GO:0001931IEA-uropod-
GO:0005615IDA-extracellular space16502470
GO:0005737IDA-cytoplasm23106337
GO:0005768IDA-endosome21148287
GO:0005829IDA-cytosol9852149
GO:0005829TAS-cytosol-
GO:0005884IDA-actin filament11598191
GO:0005886IDA-plasma membrane23106337
GO:0005902IDA-microvillus12082081
GO:0005903ISS-brush border-
GO:0005925IDA-focal adhesion21423176
GO:0005925IDAcolocalizes_withfocal adhesion21282464
GO:0015629IDA-actin cytoskeleton10793131
GO:0016020IDA-membrane19946888
GO:0016323ISS-basolateral plasma membrane-
GO:0016324IDA-apical plasma membrane17825285
GO:0019898IDA-extrinsic component of membrane7844168
GO:0030175IDA-filopodium12082081
GO:0030315IEA-T-tubule-
GO:0030863TAS-cortical cytoskeleton11598191
GO:0031528IEA-microvillus membrane-
GO:0031982IDA-vesicle19190083
GO:0032587IEA-ruffle membrane-
GO:0036064IEA-ciliary basal body-
GO:0036398IDANOT colocalizes_withTCR signalosome20551903
GO:0042995IDA-cell projection25889165
GO:0043209IEA-myelin sheath-
GO:0044297IEA-cell body-
GO:0044393IEA-microspike-
GO:0044853IDA-plasma membrane raft17911601
GO:0045177IDA-apical part of cell12082081
GO:0048471IDA-perinuclear region of cytoplasm24862762
GO:0051286IEA-cell tip-
GO:0070062IDA-extracellular exosome20458337
GO:0071944IDA-cell periphery22291017
GO:0097449IEA-astrocyte projection-
GO:0097454IEA-Schwann cell microvillus-
GO:0098592IDA-cytoplasmic side of apical plasma membrane25591774
GO ID Evidence Qualifier GO_term References
GO:0003723IDA-RNA binding22658674
GO:0003779IDA-actin binding17825285
GO:0005515IPI-protein binding7844168
GO:0008017IMP-microtubule binding23857773
GO:0008022IEA-protein C-terminus binding-
GO:0019904IPI-protein domain specific binding25554515
GO:0034236IPI-protein kinase A catalytic subunit binding17911601
GO:0034237IPI-protein kinase A regulatory subunit binding17911601
GO:0044548IPI-S100 protein binding25554515
GO:0045296IDA-cadherin binding25468996
GO:0050839IPI-cell adhesion molecule binding12082081
GO:0051015IDA-actin filament binding10793131
GO:0051117IPI-ATPase binding17825285
GO:0097718IEA-disordered domain specific binding-
GO ID Evidence Qualifier GO_term References
GO:0000122IMP-negative regulation of transcription from RNA polymerase II promoter20551903
GO:0001951IEA-intestinal D-glucose absorption-
GO:0003376IMP-sphingosine-1-phosphate signaling pathway23106337
GO:0007016NAS-cytoskeletal anchoring at plasma membrane10793131
GO:0007159IEP-leukocyte cell-cell adhesion12082081
GO:0007411TAS-axon guidance-
GO:0008360IMP-regulation of cell shape20551903
GO:0008361IMPNOTregulation of cell size22467863
GO:0010628IGI-positive regulation of gene expression23264465
GO:0010737IMP-protein kinase A signaling17911601
GO:0022612IMPNOTgland morphogenesis24862762
GO:0022614IEP-membrane to membrane docking12082081
GO:0030033IMP-microvillus assembly22797597
GO:0030953IMP-astral microtubule organization20551903
GO:0031532IMP-actin cytoskeleton reorganization23106337
GO:0031623IEA-receptor internalization-
GO:0032532IEA-regulation of microvillus length-
GO:0032956IMPNOTregulation of actin cytoskeleton organization20551903
GO:0034629IMP-cellular protein complex localization20551903
GO:0040018IEA-positive regulation of multicellular organism growth-
GO:0043622IMP-cortical microtubule organization20551903
GO:0045198IMPNOTestablishment of epithelial cell apical/basal polarity22797597
GO:0046847IMP-filopodium assembly23106337
GO:0048015IDA-phosphatidylinositol-mediated signaling25591774
GO:0050714IMP-positive regulation of protein secretion25591774
GO:0050860IMP-negative regulation of T cell receptor signaling pathway20551903
GO:0051017IDA-actin filament bundle assembly10793131
GO:0051660IMP-establishment of centrosome localization20551903
GO:0061028IGI-establishment of endothelial barrier23264465
GO:0070373IMP-negative regulation of ERK1 and ERK2 cascade20551903
GO:0071320IMP-cellular response to cAMP17911601
GO:0072697IMP-protein localization to cell cortex25554515
GO:0090002IMP-establishment of protein localization to plasma membrane17825285
GO:0090004IEA-positive regulation of establishment of protein localization to plasma membrane-
GO:1900041IMP-negative regulation of interleukin-2 secretion17911601
GO:1901222IMPNOTregulation of NIK/NF-kappaB signaling20551903
GO:1902115IGI-regulation of organelle assembly21148287
GO:1902115IMP-regulation of organelle assembly21148287
GO:1902896IEA-terminal web assembly-
GO:1902966IGI-positive regulation of protein localization to early endosome21148287
GO:1903364IGI-positive regulation of cellular protein catabolic process21148287
GO:1903753IMP-negative regulation of p38MAPK cascade20551903
GO:2000643IGI-positive regulation of early endosome to late endosome transport21148287
GO:2000643IMP-positive regulation of early endosome to late endosome transport21148287
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
EZRADORA2B11327112080047 Affinity Capture-Western
EZRADORA2B10664812080047 Affinity Capture-Western
EZRFAS10685115659383 Co-purification
EZRFAS11327115659383 Co-purification
EZRFASLG11327111013215 15659383 Affinity Capture-Western; Co-purification
EZRFASLG10685211013215 15659383 Affinity Capture-Western; Co-purification
EZRRHOA11327115659383 Co-purification
EZRRHOA10688015659383 Co-purification
EZRARHGDIA10688915659383 Co-purification
EZRARHGDIA11327115659383 Co-purification
EZRBID11327115659383 Co-purification
EZRBID10710615659383 Co-purification
EZRCASP811327115659383 Co-purification
EZRCASP810729115659383 Co-purification
EZRCASP1011327115659383 Co-purification
EZRCASP1010729315659383 Co-purification
EZRCD4411327112032545 Reconstituted Complex
EZRCD4410739812032545 Reconstituted Complex
EZRCDH111327110462524 Affinity Capture-Western
EZRCDH110743410462524 Affinity Capture-Western
EZRCFTR10750610893422 Affinity Capture-Western
EZRCFTR11327110893422 Affinity Capture-Western
EZRCTNNB110788010462524 Affinity Capture-Western
EZRCTNNB111327110462524 Affinity Capture-Western
EZRDLG110808311726633 Reconstituted Complex
EZRDLG111327111726633 Reconstituted Complex
EZRHLA-B11327117353931 Affinity Capture-MS
EZRHLA-B10935117353931 Affinity Capture-MS
EZRICAM11132719705328 Affinity Capture-Western; Reconstituted Complex
EZRICAM11096109705328 Affinity Capture-Western; Reconstituted Complex
EZRICAM21132719705328 Affinity Capture-Western; Reconstituted Complex
EZRICAM21096119705328 Affinity Capture-Western; Reconstituted Complex
EZRICAM31132719705328 11784723 Affinity Capture-Western; Reconstituted Complex
EZRICAM31096129705328 11784723 Affinity Capture-Western; Reconstituted Complex
EZRL1CAM11009412070130 Reconstituted Complex
EZRL1CAM11327112070130 Reconstituted Complex
EZRMCC11327117353931 Affinity Capture-MS
EZRMCC11033317353931 Affinity Capture-MS
EZRMSN1105847579708 8248180 15659383 Affinity Capture-Western; Co-purification; Reconstituted Complex
EZRMSN1132717579708 8248180 15659383 Affinity Capture-Western; Co-purification; Reconstituted Complex
EZRNF211327110036239 17891137 Affinity Capture-Western; Far Western; Reconstituted Complex
EZRNF211084410036239 17891137 Affinity Capture-Western; Far Western; Reconstituted Complex
EZRPIK3R111327110377409 Affinity Capture-Western; Reconstituted Complex
EZRPIK3R111131310377409 Affinity Capture-Western; Reconstituted Complex
EZRPPL11148814625392 Affinity Capture-MS
EZRPPL11327114625392 Affinity Capture-MS
EZRPRKAB111155117353931 Affinity Capture-MS
EZRPRKAB111327117353931 Affinity Capture-MS
EZRPRKCA11327111387207 Affinity Capture-Western
EZRPRKCA11156411387207 Affinity Capture-Western
EZRMAPK811158515659383 Co-purification
EZRMAPK811327115659383 Co-purification
EZRPTK211171911468295 Reconstituted Complex
EZRPTK211327111468295 Reconstituted Complex
EZRS100P11219412808036 Affinity Capture-MS; Reconstituted Complex
EZRS100P11327112808036 Affinity Capture-MS; Reconstituted Complex
EZRSDC211228510704377 Affinity Capture-Western; Reconstituted Complex
EZRSDC211327110704377 Affinity Capture-Western; Reconstituted Complex
EZRSELL11230211706008 Reconstituted Complex
EZRSELL11327111706008 Reconstituted Complex
EZRSELP11230310733515 Reconstituted Complex
EZRSELP11327110733515 Reconstituted Complex
EZRSPN1125719616160 Affinity Capture-Western; Reconstituted Complex
EZRSPN1132719616160 Affinity Capture-Western; Reconstituted Complex
EZRSPTA111258614625392 Affinity Capture-MS
EZRSPTA111327114625392 Affinity Capture-MS
EZRTNFRSF1A11298615659383 Co-purification
EZRTNFRSF1A11327115659383 Co-purification
EZRTSC111309910806479 Affinity Capture-Western
EZRTSC111327110806479 Affinity Capture-Western
EZRVCAM111325512082081 Affinity Capture-Western; Reconstituted Complex
EZRVCAM111327112082081 Affinity Capture-Western; Reconstituted Complex
SLC9A3R1EZR1147699314537 11684085 Affinity Capture-Western; Reconstituted Complex
SLC9A3R1EZR1132719314537 11684085 Affinity Capture-Western; Reconstituted Complex
EZREZR1132719501018 Two-hybrid
SLC9A3R2EZR1147549748260 12080047 Affinity Capture-Western; Reconstituted Complex
SLC9A3R2EZR1132719748260 12080047 Affinity Capture-Western; Reconstituted Complex
CLIC5EZR11978110793131 Reconstituted Complex
CLIC5EZR11327110793131 Reconstituted Complex
IQGAP1EZR11435310793131 Reconstituted Complex
IQGAP1EZR11327110793131 Reconstituted Complex
PALLDEZR11327111598191 Far Western; Reconstituted Complex; Two-hybrid
PALLDEZR11666211598191 Far Western; Reconstituted Complex; Two-hybrid
SCYL3EZR12140412651155 Two-hybrid
SCYL3EZR11327112651155 Two-hybrid
PRXEZR12173914625392 Affinity Capture-MS
PRXEZR11327114625392 Affinity Capture-MS
AHNAKEZR12249414625392 Affinity Capture-MS
AHNAKEZR11327114625392 Affinity Capture-MS
FADDEZR11430215659383 Co-purification
FADDEZR11327115659383 Co-purification
TNFRSF10BEZR11432315659383 Co-purification
TNFRSF10BEZR11327115659383 Co-purification
GABARAPL2EZR11647317353931 Affinity Capture-MS
GABARAPL2EZR11327117353931 Affinity Capture-MS
PHLPP2EZR11667419615732 Affinity Capture-MS
PHLPP2EZR11327119615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:98931
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050803-1'