AutismKB 2.0

Annotation Details for WAS


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Basic Information Top
Gene Symbol:WAS ( IMD2,THC,THC1,WASP )
Gene Full Name: Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
Band: Xp11.23
Quick LinksEntrez ID:7454; OMIM: 300392; Uniprot ID:WASP_HUMAN; ENSEMBL ID: ENSG00000015285; HGNC ID: 12731
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005829IDA-cytosol8625410
GO:0005829TAS-cytosol-
GO:0005884IDA-actin filament8625410
GO:0005911IEA-cell-cell junction-
GO:0012506IEA-vesicle membrane-
GO:0015629TAS-actin cytoskeleton8625410
GO:0070062IDA-extracellular exosome20458337
GO ID Evidence Qualifier GO_term References
GO:0003779IEA-actin binding-
GO:0005515IPI-protein binding8892607
GO:0017124IPI-SH3 domain binding8892607
GO:0019901IPI-protein kinase binding8892607
GO:0030695TAS-GTPase regulator activity8625410
GO:0031267IPI-small GTPase binding8625410
GO:0042802IPI-identical protein binding10724160
GO:0043274IPI-phospholipase binding8892607
GO:0048365IPI-Rac GTPase binding8625410
GO ID Evidence Qualifier GO_term References
GO:0002625IMP-regulation of T cell antigen processing and presentation22804504
GO:0006461TAS-protein complex assembly8625410
GO:0006952TAS-defense response8069912
GO:0006955IMP-immune response8069912
GO:0007266IMPNOTRho protein signal transduction8625410
GO:0007596TAS-blood coagulation8069912
GO:0008064IMP-regulation of actin polymerization or depolymerization8625410
GO:0008154TAS-actin polymerization or depolymerization8625410
GO:0008544TAS-epidermis development8069912
GO:0010591IGI-regulation of lamellipodium assembly8625410
GO:0016197IEA-endosomal transport-
GO:0030041IEA-actin filament polymerization-
GO:0030048IEA-actin filament-based movement-
GO:0032488IMP-Cdc42 protein signal transduction8625410
GO:0038096TAS-Fc-gamma receptor signaling pathway involved in phagocytosis-
GO:0042110IEA-T cell activation-
GO:0050790IEA-regulation of catalytic activity-
GO:0050852TAS-T cell receptor signaling pathway-
GO:0051492IGI-regulation of stress fiber assembly8625410
GO:0051497IMP-negative regulation of stress fiber assembly8625410
GO:2000146IMP-negative regulation of cell motility22804504
GO:2000601IEA-positive regulation of Arp2/3 complex-mediated actin nucleation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
WASAPBB111329316055720 Affinity Capture-MS
WASAPBB110681916055720 Affinity Capture-MS
WASBTK1071608892607 Reconstituted Complex
WASBTK1132938892607 Reconstituted Complex
WASCDC421132938625410 8643625 10713100 10724160 20936779 Reconstituted Complex; Two-hybrid
WASCDC421074338625410 8643625 10713100 10724160 20936779 Reconstituted Complex; Two-hybrid
WASCRKL10778911313252 Affinity Capture-Western; Reconstituted Complex
WASCRKL11329311313252 Affinity Capture-Western; Reconstituted Complex
WASEGFR1082769307968 Affinity Capture-Western
WASEGFR1132939307968 Affinity Capture-Western
WASFGR1085597565724 8805332 8824280 Affinity Capture-Western; Reconstituted Complex
WASFGR1132937565724 8805332 8824280 Affinity Capture-Western; Reconstituted Complex
WASFYB11329310747096 Affinity Capture-Western
WASFYB10880910747096 Affinity Capture-Western
WASFYN1132937565724 8805332 10532312 Affinity Capture-Western; Reconstituted Complex
WASFYN1088107565724 8805332 10532312 Affinity Capture-Western; Reconstituted Complex
WASGRB21091428805332 9307968 Affinity Capture-Western; Reconstituted Complex
WASGRB21132938805332 9307968 Affinity Capture-Western; Reconstituted Complex
WASHCK11329312029088 Reconstituted Complex
WASHCK10930512029088 Reconstituted Complex
WASITK1099078810341 8892607 Reconstituted Complex
WASITK1132938810341 8892607 Reconstituted Complex
WASLCP211329310747096 Affinity Capture-Western
WASLCP211012910747096 Affinity Capture-Western
WASNCK11107707565724 10747096 12135674 Affinity Capture-Western; Reconstituted Complex
WASNCK11132937565724 10747096 12135674 Affinity Capture-Western; Reconstituted Complex
WASPIK3R11132938805332 Affinity Capture-Western; Reconstituted Complex
WASPIK3R11113138805332 Affinity Capture-Western; Reconstituted Complex
WASPLCG11113518805332 8824280 Reconstituted Complex
WASPLCG11132938805332 8824280 Reconstituted Complex
WASRAC11132938643625 Reconstituted Complex
WASRAC11118178643625 Reconstituted Complex
WASSRC1125928805332 8824280 Affinity Capture-Western; Reconstituted Complex
WASSRC1132938805332 8824280 Affinity Capture-Western; Reconstituted Complex
WASTEC1132938892607 Reconstituted Complex
WASTEC1128658892607 Reconstituted Complex
WASVASP11325111598004 Reconstituted Complex
WASVASP11329311598004 Reconstituted Complex
WIPF1WAS1132959405671 9694849 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
WIPF1WAS1132939405671 9694849 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PSTPIP1WAS1145139488710 19041431 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
PSTPIP1WAS1132939488710 19041431 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
ARPC3WAS1132939889097 Two-hybrid
ARPC3WAS1154019889097 Two-hybrid
TRIP10WAS11329310713100 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TRIP10WAS11473310713100 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RHOJWAS11329310967094 Two-hybrid
RHOJWAS12149910967094 Two-hybrid
ITSN2WAS11909811748279 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ITSN2WAS11329311748279 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
WIPF2WAS11329312213210 Affinity Capture-Western
WIPF2WAS12704312213210 Affinity Capture-Western
TCERG1WAS11612016055720 Affinity Capture-MS
TCERG1WAS11329316055720 Affinity Capture-MS
WBP4WAS11636316055720 Affinity Capture-MS
WBP4WAS11329316055720 Affinity Capture-MS
PRPF40AWAS11329316055720 Affinity Capture-MS
PRPF40AWAS12079216055720 Affinity Capture-MS
GAS7WAS11409416055720 Affinity Capture-MS
GAS7WAS11329316055720 Affinity Capture-MS
PACSIN2WAS11329319041431 Affinity Capture-MS
PACSIN2WAS11641319041431 Affinity Capture-MS
FNBP1WAS11329319041431 Affinity Capture-MS
FNBP1WAS11668619041431 Affinity Capture-MS
SRGAP2WAS11695619041431 Affinity Capture-MS
SRGAP2WAS11329319041431 Affinity Capture-MS
PACSIN3WAS11329319041431 Affinity Capture-MS
PACSIN3WAS11889619041431 Affinity Capture-MS
PACSIN1WAS11329319041431 Affinity Capture-MS
PACSIN1WAS11901819041431 Affinity Capture-MS
Gene Symbol Interactant Interaction ID References Description
WASCDC4226347615735674 Active GTP-bound CDC42 interacts with WAS (WASP). This interaction was modelled on a demonstrated interaction between chicken CDC42 and human WAS.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:105059
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-7098'