AutismKB 2.0

Annotation Details for WNT1


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Basic Information Top
Gene Symbol:WNT1 ( INT1 )
Gene Full Name: wingless-type MMTV integration site family, member 1
Band: 12q13.12
Quick LinksEntrez ID:7471; OMIM: 164820; Uniprot ID:WNT1_HUMAN; ENSEMBL ID: ENSG00000125084; HGNC ID: 12774
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005578IEA-proteinaceous extracellular matrix-
GO:0005615IBA-extracellular space-
GO:0005737IDA-cytoplasm11793365
GO:0005788TAS-endoplasmic reticulum lumen-
GO:0005796TAS-Golgi lumen-
GO:0005886TAS-plasma membrane-
GO:0009986IEA-cell surface-
GO:0030666TAS-endocytic vesicle membrane-
GO:0070062TAS-extracellular exosome-
GO ID Evidence Qualifier GO_term References
GO:0005109IBA-frizzled binding-
GO:0005109IC-frizzled binding19756656
GO:0005109NAS-frizzled binding23461676
GO:0005125ISS-cytokine activity-
GO:0016015TAS-morphogen activity24431302
GO:0019904IEA-protein domain specific binding-
GO:0044212IDA-transcription regulatory region DNA binding19847889
GO:0048018IC-receptor agonist activity19778454
GO:0048018NAS-receptor agonist activity23461676
GO ID Evidence Qualifier GO_term References
GO:0000578ISS-embryonic axis specification-
GO:0001658IEA-branching involved in ureteric bud morphogenesis-
GO:0001934IEA-positive regulation of protein phosphorylation-
GO:0007267ISS-cell-cell signaling-
GO:0007520IEA-myoblast fusion-
GO:0008284IDA-positive regulation of cell proliferation16501043
GO:0008284IMP-positive regulation of cell proliferation19778454
GO:0009611IEP-response to wounding17982423
GO:0010592IMP-positive regulation of lamellipodium assembly19756656
GO:0010812IDA-negative regulation of cell-substrate adhesion16501043
GO:0016055IDA-Wnt signaling pathway10644691
GO:0016055TAS-Wnt signaling pathway-
GO:0021527IEA-spinal cord association neuron differentiation-
GO:0021536IEA-diencephalon development-
GO:0021551ISS-central nervous system morphogenesis-
GO:0021588ISS-cerebellum formation-
GO:0021797IEA-forebrain anterior/posterior pattern specification-
GO:0022004IEA-midbrain-hindbrain boundary maturation during brain development-
GO:0022408IMP-negative regulation of cell-cell adhesion17072303
GO:0030512IEA-negative regulation of transforming growth factor beta receptor signaling pathway-
GO:0030514IMP-negative regulation of BMP signaling pathway16194878
GO:0030579IEA-ubiquitin-dependent SMAD protein catabolic process-
GO:0030901ISS-midbrain development-
GO:0031100IEA-animal organ regeneration-
GO:0033077IEA-T cell differentiation in thymus-
GO:0033278IEA-cell proliferation in midbrain-
GO:0036520IEA-astrocyte-dopaminergic neuron signaling-
GO:0042472IEA-inner ear morphogenesis-
GO:0042770IDA-signal transduction in response to DNA damage16501043
GO:0043568IDA-positive regulation of insulin-like growth factor receptor signaling pathway12154096
GO:0044336IMP-canonical Wnt signaling pathway involved in negative regulation of apoptotic process12154096
GO:0045165IBA-cell fate commitment-
GO:0045599ISS-negative regulation of fat cell differentiation-
GO:0045747IDA-positive regulation of Notch signaling pathway16501043
GO:0045893IDA-positive regulation of transcription, DNA-templated10644691
GO:0045893IMP-positive regulation of transcription, DNA-templated19847889
GO:0045893ISS-positive regulation of transcription, DNA-templated-
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0048146IMP-positive regulation of fibroblast proliferation19734317
GO:0048664IEA-neuron fate determination-
GO:0051091ISS-positive regulation of sequence-specific DNA binding transcription factor activity-
GO:0060061ISS-Spemann organizer formation-
GO:0060070IMP-canonical Wnt signaling pathway19756656
GO:0060070NAS-canonical Wnt signaling pathway23461676
GO:0060070TAS-canonical Wnt signaling pathway24431302
GO:0060071TAS-Wnt signaling pathway, planar cell polarity pathway-
GO:0060348IMP-bone development23499309
GO:0061184IDA-positive regulation of dermatome development10654605
GO:0070365IEA-hepatocyte differentiation-
GO:0071375IEA-cellular response to peptide hormone stimulus-
GO:0071425IEA-hematopoietic stem cell proliferation-
GO:0090263IEA-positive regulation of canonical Wnt signaling pathway-
GO:0090344IDA-negative regulation of cell aging16501043
GO:1903204IEA-negative regulation of oxidative stress-induced neuron death-
GO:1904886TAS-beta-catenin destruction complex disassembly-
GO:1904953NAS-Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation23461676
GO:1904953TAS-Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation24431302
GO:1904954TAS-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation22988876
GO:1990403IEA-embryonic brain development-
GO:2000059IEA-negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process-
GO:2000273IEA-positive regulation of receptor activity-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
WNT1LRP611330811448771 Affinity Capture-Western
WNT1LRP611021911448771 Affinity Capture-Western
WNT1SFRP111330810347172 Affinity Capture-Western
WNT1SFRP111232010347172 Affinity Capture-Western
FZD8WNT111330811448771 Affinity Capture-Western
FZD8WNT111392111448771 Affinity Capture-Western
WIF1WNT111330819174556 Affinity Capture-Western
WIF1WNT111636619174556 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:98953
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-980526-526'