AutismKB 2.0

Annotation Details for WNT2


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Basic Information Top
Gene Symbol:WNT2 ( INT1L1,IRP )
Gene Full Name: wingless-type MMTV integration site family member 2
Band: 7q31.2
Quick LinksEntrez ID:7472; OMIM: 147870; Uniprot ID:WNT2_HUMAN; ENSEMBL ID: ENSG00000105989; HGNC ID: 12780
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576NAS-extracellular region2971536
GO:0005576TAS-extracellular region-
GO:0005578IEA-proteinaceous extracellular matrix-
GO:0005615IBA-extracellular space-
GO:0005737IDA-cytoplasm19038973
GO:0005886IDAcolocalizes_withplasma membrane19038973
GO:0031012IDA-extracellular matrix15507471
GO:1990909IC-Wnt signalosome10557084
GO ID Evidence Qualifier GO_term References
GO:0005109IPI-frizzled binding10557084
GO:0005125IDA-cytokine activity10557084
GO:0005515IPI-protein binding10347172
GO:0048018IC-receptor agonist activity17948129
GO:0048018IDA-receptor agonist activity10557084
GO ID Evidence Qualifier GO_term References
GO:0001938IEA-positive regulation of endothelial cell proliferation-
GO:0002053IEA-positive regulation of mesenchymal cell proliferation-
GO:0002088ISS-lens development in camera-type eye16258938
GO:0007267IDA-cell-cell signaling10557084
GO:0008284IDA-positive regulation of cell proliferation10347172
GO:0016055IDA-Wnt signaling pathway10557084
GO:0016055TAS-Wnt signaling pathway-
GO:0022008TAS-neurogenesis24431302
GO:0030182ISS-neuron differentiation-
GO:0030324IEA-lung development-
GO:0033278IDA-cell proliferation in midbrain20018874
GO:0045165IBA-cell fate commitment-
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter20018874
GO:0048146IMP-positive regulation of fibroblast proliferation19734317
GO:0050769IEA-positive regulation of neurogenesis-
GO:0051091IDA-positive regulation of sequence-specific DNA binding transcription factor activity10557084
GO:0055009IEA-atrial cardiac muscle tissue morphogenesis-
GO:0060045IEA-positive regulation of cardiac muscle cell proliferation-
GO:0060070IDA-canonical Wnt signaling pathway10347172
GO:0060070TAS-canonical Wnt signaling pathway24431302
GO:0060317IEA-cardiac epithelial to mesenchymal transition-
GO:0060492IEA-lung induction-
GO:0060501IEA-positive regulation of epithelial cell proliferation involved in lung morphogenesis-
GO:0060716IEA-labyrinthine layer blood vessel development-
GO:0061072ISS-iris morphogenesis16258938
GO:0061180IEP-mammary gland epithelium development8168088
GO:0071300ISS-cellular response to retinoic acid-
GO:0071560IEP-cellular response to transforming growth factor beta stimulus15040835
GO:0090263IMP-positive regulation of canonical Wnt signaling pathway17948129
GO:1904948IDA-midbrain dopaminergic neuron differentiation20018874
GO:1904954IDA-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation20018874
GO:2000273IEA-positive regulation of receptor activity-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
WNT2SFRP111330910347172 Affinity Capture-Western
WNT2SFRP111232010347172 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
WNT2rs17132543, rs2024233, rs3779548, rs39315, rs4730775, rs733154 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:98954
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-980526-416'