AutismKB 2.0

Annotation Details for WNT5A


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Basic Information Top
Gene Symbol:WNT5A ( hWNT5A )
Gene Full Name: wingless-type MMTV integration site family, member 5A
Band: 3p14.3
Quick LinksEntrez ID:7474; OMIM: 164975; Uniprot ID:WNT5A_HUMAN; ENSEMBL ID: ENSG00000114251; HGNC ID: 12784
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005578IEA-proteinaceous extracellular matrix-
GO:0005615IDA-extracellular space18703641
GO:0005788TAS-endoplasmic reticulum lumen-
GO:0005796TAS-Golgi lumen-
GO:0005886TAS-plasma membrane-
GO:0009986IEA-cell surface-
GO:0030665TAS-clathrin-coated vesicle membrane-
GO:0030666TAS-endocytic vesicle membrane-
GO:0030669TAS-clathrin-coated endocytic vesicle membrane-
GO:0070062TAS-extracellular exosome-
GO ID Evidence Qualifier GO_term References
GO:0003700IMP-transcription factor activity, sequence-specific DNA binding19847889
GO:0005109IPI-frizzled binding18174455
GO:0005110IEA-frizzled-2 binding-
GO:0005115IPI-receptor tyrosine kinase-like orphan receptor binding18287027
GO:0005125IEA-cytokine activity-
GO:0005515IPI-protein binding26342861
GO:0019904IEA-protein domain specific binding-
GO:0044212IDA-transcription regulatory region DNA binding19847889
GO:0048018IC-receptor agonist activity18174455
GO:1902379IEA-chemoattractant activity involved in axon guidance-
GO ID Evidence Qualifier GO_term References
GO:0000187IDA-activation of MAPK activity20034610
GO:0001736IEA-establishment of planar polarity-
GO:0001756IEA-somitogenesis-
GO:0001837IEP-epithelial to mesenchymal transition12841867
GO:0001938IMP-positive regulation of endothelial cell proliferation17986384
GO:0001947IEA-heart looping-
GO:0002053IEA-positive regulation of mesenchymal cell proliferation-
GO:0002088ISS-lens development in camera-type eye16258938
GO:0002741IMP-positive regulation of cytokine secretion involved in immune response18174455
GO:0003323IEA-type B pancreatic cell development-
GO:0003402IEA-planar cell polarity pathway involved in axis elongation-
GO:0003408ISS-optic cup formation involved in camera-type eye development16258938
GO:0007223IDA-Wnt signaling pathway, calcium modulating pathway19946729
GO:0007223IMP-Wnt signaling pathway, calcium modulating pathway17986384
GO:0007223NAS-Wnt signaling pathway, calcium modulating pathway24431302
GO:0007257IDA-activation of JUN kinase activity20034610
GO:0007257IMP-activation of JUN kinase activity20032469
GO:0007411ISS-axon guidance-
GO:0007442IEA-hindgut morphogenesis-
GO:0007494IEA-midgut development-
GO:0008584IEP-male gonad development17848411
GO:0008595IEA-anterior/posterior axis specification, embryo-
GO:0010033IEP-response to organic substance17486081
GO:0010595IMP-positive regulation of endothelial cell migration17035633
GO:0010800IEA-positive regulation of peptidyl-threonine phosphorylation-
GO:0010820IMP-positive regulation of T cell chemotaxis19520808
GO:0010976ISS-positive regulation of neuron projection development-
GO:0016055IDA-Wnt signaling pathway20034610
GO:0016055TAS-Wnt signaling pathway-
GO:0021891ISS-olfactory bulb interneuron development-
GO:0030182ISS-neuron differentiation-
GO:0030216IEP-keratinocyte differentiation19399181
GO:0030324IEA-lung development-
GO:0030514IEA-negative regulation of BMP signaling pathway-
GO:0030825IDA-positive regulation of cGMP metabolic process19946729
GO:0032092IEA-positive regulation of protein binding-
GO:0032148IDA-activation of protein kinase B activity20034610
GO:0032729IEA-positive regulation of interferon-gamma production-
GO:0032755IMP-positive regulation of interleukin-6 production18174455
GO:0033138IEA-positive regulation of peptidyl-serine phosphorylation-
GO:0034613IDA-cellular protein localization19177143
GO:0035567TAS-non-canonical Wnt signaling pathway24449494
GO:0036342IEA-post-anal tail morphogenesis-
GO:0036517IEA-chemoattraction of serotonergic neuron axon-
GO:0036518IEA-chemorepulsion of dopaminergic neuron axon-
GO:0038031IEA-non-canonical Wnt signaling pathway via JNK cascade-
GO:0040037IEA-negative regulation of fibroblast growth factor receptor signaling pathway-
GO:0042060IDA-wound healing19878652
GO:0042733IEA-embryonic digit morphogenesis-
GO:0043032IMP-positive regulation of macrophage activation18174455
GO:0043066IDA-negative regulation of apoptotic process19251946
GO:0045080IMP-positive regulation of chemokine biosynthetic process19520808
GO:0045165IBA-cell fate commitment-
GO:0045198IEA-establishment of epithelial cell apical/basal polarity-
GO:0045599IMP-negative regulation of fat cell differentiation20032469
GO:0045732IGI-positive regulation of protein catabolic process12952940
GO:0045766IMP-positive regulation of angiogenesis17035633
GO:0045778IMP-positive regulation of ossification20032469
GO:0045807IEA-positive regulation of endocytosis-
GO:0045836IEA-positive regulation of meiotic nuclear division-
GO:0045892IDA-negative regulation of transcription, DNA-templated19277043
GO:0045893IMP-positive regulation of transcription, DNA-templated19847889
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter18174455
GO:0048022IEA-negative regulation of melanin biosynthetic process-
GO:0048146IDA-positive regulation of fibroblast proliferation19251946
GO:0048341IEA-paraxial mesoderm formation-
GO:0048570IEA-notochord morphogenesis-
GO:0048706IMP-embryonic skeletal system development19918918
GO:0048806IMP-genitalia development19918918
GO:0048843IEA-negative regulation of axon extension involved in axon guidance-
GO:0048850IEA-hypophysis morphogenesis-
GO:0050680IEA-negative regulation of epithelial cell proliferation-
GO:0050718IMP-positive regulation of interleukin-1 beta secretion18174455
GO:0050729IMP-positive regulation of inflammatory response18174455
GO:0051092IDA-positive regulation of NF-kappaB transcription factor activity18287027
GO:0051216IEA-cartilage development-
GO:0051885IEA-positive regulation of timing of anagen-
GO:0051964IEA-negative regulation of synapse assembly-
GO:0060021IMP-palate development18413325
GO:0060028IEA-convergent extension involved in axis elongation-
GO:0060029IEA-convergent extension involved in organogenesis-
GO:0060065IEA-uterus development-
GO:0060067IEA-cervix development-
GO:0060068IEA-vagina development-
GO:0060070IEA-canonical Wnt signaling pathway-
GO:0060071TAS-Wnt signaling pathway, planar cell polarity pathway24431302
GO:0060157IEA-urinary bladder development-
GO:0060324IMP-face development19918918
GO:0060340IDA-positive regulation of type I interferon-mediated signaling pathway19399181
GO:0060599IEA-lateral sprouting involved in mammary gland duct morphogenesis-
GO:0060638IEA-mesenchymal-epithelial cell signaling-
GO:0060686IEA-negative regulation of prostatic bud formation-
GO:0060744IEA-mammary gland branching involved in thelarche-
GO:0060750IEA-epithelial cell proliferation involved in mammary gland duct elongation-
GO:0060760IDA-positive regulation of response to cytokine stimulus19399181
GO:0060762IEA-regulation of branching involved in mammary gland duct morphogenesis-
GO:0060775IEA-planar cell polarity pathway involved in gastrula mediolateral intercalation-
GO:0060809IEA-mesodermal to mesenchymal transition involved in gastrulation-
GO:0060907IMP-positive regulation of macrophage cytokine production18174455
GO:0061024TAS-membrane organization-
GO:0061036IEA-positive regulation of cartilage development-
GO:0061347IEA-planar cell polarity pathway involved in outflow tract morphogenesis-
GO:0061348IEA-planar cell polarity pathway involved in ventricular septum morphogenesis-
GO:0061349IEA-planar cell polarity pathway involved in cardiac right atrium morphogenesis-
GO:0061350IEA-planar cell polarity pathway involved in cardiac muscle tissue morphogenesis-
GO:0061354IEA-planar cell polarity pathway involved in pericardium morphogenesis-
GO:0070245IEA-positive regulation of thymocyte apoptotic process-
GO:0071222IEP-cellular response to lipopolysaccharide18174455
GO:0071277IEP-cellular response to calcium ion18703641
GO:0071300ISS-cellular response to retinoic acid-
GO:0071346IEP-cellular response to interferon-gamma18174455
GO:0071425IDA-hematopoietic stem cell proliferation9787155
GO:0071560IEP-cellular response to transforming growth factor beta stimulus15040835
GO:0072201IDA-negative regulation of mesenchymal cell proliferation19878652
GO:0090009IEA-primitive streak formation-
GO:0090037IMP-positive regulation of protein kinase C signaling19099253
GO:0090090IDA-negative regulation of canonical Wnt signaling pathway17976063
GO:0090090IGI-negative regulation of canonical Wnt signaling pathway12952940
GO:0090103IEA-cochlea morphogenesis-
GO:0090179IEA-planar cell polarity pathway involved in neural tube closure-
GO:0090263IEA-positive regulation of canonical Wnt signaling pathway-
GO:0090630IEA-activation of GTPase activity-
GO:0097325IEA-melanocyte proliferation-
GO:0099054TAS-presynapse assembly24449494
GO:0099068TAS-postsynapse assembly24449494
GO:1900020IMP-positive regulation of protein kinase C activity12086864
GO:1902474TAS-positive regulation of protein localization to synapse24449494
GO:1903827IEA-regulation of cellular protein localization-
GO:1904861TAS-excitatory synapse assembly24449494
GO:1904862TAS-inhibitory synapse assembly24449494
GO:1904934NAS-negative regulation of cell proliferation in midbrain24431302
GO:1904938IEA-planar cell polarity pathway involved in axon guidance-
GO:1904953NAS-Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation24431302
GO:1904955TAS-planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation22988876
GO:2000049IEA-positive regulation of cell-cell adhesion mediated by cadherin-
GO:2000052IEA-positive regulation of non-canonical Wnt signaling pathway-
GO:2000273IEA-positive regulation of receptor activity-
GO:2000484IEA-positive regulation of interleukin-8 secretion-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
FZD1WNT5A11331110557084 Affinity Capture-Western
FZD1WNT5A11391710557084 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
WNT5Ars648872, rs7622120 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:98958
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-060328-3'