AutismKB 2.0

Annotation Details for WRN


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Basic Information Top
Gene Symbol:WRN ( DKFZp686C2056,RECQ3,RECQL2,RECQL3 )
Gene Full Name: Werner syndrome, RecQ helicase-like
Band: 8p12
Quick LinksEntrez ID:7486; OMIM: 604611; Uniprot ID:WRN_HUMAN; ENSEMBL ID: ENSG00000165392; HGNC ID: 12791
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000781IDA-chromosome, telomeric region15200954
GO:0005654IDA-nucleoplasm11420665
GO:0005654TAS-nucleoplasm-
GO:0005657ISS-replication fork-
GO:0005694IBA-chromosome-
GO:0005730IDA-nucleolus9618508
GO:0005737IBA-cytoplasm-
GO:0005813IDA-centrosome17498979
GO:0016607IDA-nuclear speck-
GO:0032389IDAcolocalizes_withMutLalpha complex17715146
GO:0043005IEA-neuron projection-
GO ID Evidence Qualifier GO_term References
GO:0000287IDA-magnesium ion binding16622405
GO:0000400IDA-four-way junction DNA binding11735402
GO:0000403IDA-Y-form DNA binding11735402
GO:0000405IDA-bubble DNA binding11433031
GO:0003677IDA-DNA binding9288107
GO:0003678IDA-DNA helicase activity12944467
GO:0003678IMP-DNA helicase activity10871376
GO:0003682IEA-chromatin binding-
GO:0004003IDA-ATP-dependent DNA helicase activity9288107
GO:0004386IDA-helicase activity12181313
GO:0004527IDA-exonuclease activity12944467
GO:0004527IMP-exonuclease activity15200954
GO:0005515IPI-protein binding10373438
GO:0005524IEA-ATP binding-
GO:0008408IDA-3'-5' exonuclease activity10783163
GO:0009378IDA-four-way junction helicase activity11433031
GO:0016887IDA-ATPase activity10373438
GO:0030145IDA-manganese ion binding16622405
GO:0032403IDA-protein complex binding10783163
GO:0042803IDA-protein homodimerization activity10783163
GO:0043138IDA-3'-5' DNA helicase activity17715146
GO:0043140IBA-ATP-dependent 3'-5' DNA helicase activity-
GO:0051880IDA-G-quadruplex DNA binding11433031
GO:0061749IDA-forked DNA-dependent helicase activity11735402
GO:0061821IDA-telomeric D-loop binding19734539
GO:0061849IC-telomeric G-quadruplex DNA binding19734539
GO:0070337IDA-3'-flap-structured DNA binding26420422
GO:1905773IDA-8-hydroxy-2'-deoxyguanosine DNA binding19734539
GO ID Evidence Qualifier GO_term References
GO:0000723IMP-telomere maintenance18212065
GO:0000723TAS-telomere maintenance25801465
GO:0000724IBA-double-strand break repair via homologous recombination-
GO:0000731IDA-DNA synthesis involved in DNA repair17563354
GO:0000731TAS-DNA synthesis involved in DNA repair-
GO:0000732TAS-strand displacement-
GO:0001302IEA-replicative cell aging-
GO:0006259IDA-DNA metabolic process16622405
GO:0006260IMP-DNA replication12882351
GO:0006260ISS-DNA replication-
GO:0006260TAS-DNA replication-
GO:0006284IDA-base-excision repair17611195
GO:0006302IMP-double-strand break repair21639834
GO:0006974IDA-cellular response to DNA damage stimulus18203716
GO:0006979IDA-response to oxidative stress17611195
GO:0007420IEA-brain development-
GO:0007568NAS-aging9288107
GO:0007569IMP-cell aging18212065
GO:0009267IDA-cellular response to starvation11420665
GO:0010225IDA-response to UV-C17563354
GO:0010259IMP-multicellular organism aging16673358
GO:0031297IDA-replication fork processing17115688
GO:0031297IMP-replication fork processing12882351
GO:0032066IDA-nucleolus to nucleoplasm transport11420665
GO:0032508IDA-DNA duplex unwinding11735402
GO:0040009IEA-regulation of growth rate-
GO:0042981IGI-regulation of apoptotic process9681877
GO:0044806IDA-G-quadruplex DNA unwinding11735402
GO:0044806ISS-G-quadruplex DNA unwinding-
GO:0051345IDA-positive regulation of hydrolase activity17611195
GO:0061820IDA-telomeric D-loop disassembly15200954
GO:0061820IGI-telomeric D-loop disassembly22039056
GO:0061820TAS-telomeric D-loop disassembly22039056
GO:0071480IDA-cellular response to gamma radiation21639834
GO:0090305IEA-nucleic acid phosphodiester bond hydrolysis-
GO:0090656TAS-t-circle formation27918544
GO:0098530IDA-positive regulation of strand invasion26420422
GO:1901796TAS-regulation of signal transduction by p53 class mediator-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
WRNATM11332310608806 Protein-peptide
WRNATM10696210608806 Protein-peptide
WRNATR11332310608806 Protein-peptide
WRNATR10702710608806 Protein-peptide
WRNBLM11332311919194 Affinity Capture-Western; Reconstituted Complex
WRNBLM10711011919194 Affinity Capture-Western; Reconstituted Complex
WRNDHX910802517498979 Reconstituted Complex
WRNDHX911332317498979 Reconstituted Complex
WRNFEN111332311598021 14688284 16326861 Affinity Capture-Luminescence; Affinity Capture-Western; Reconstituted Complex
WRNFEN110852811598021 14688284 16326861 Affinity Capture-Luminescence; Affinity Capture-Western; Reconstituted Complex
WRNXRCC611332310880505 12177300 Affinity Capture-Western; Reconstituted Complex
WRNXRCC610882210880505 12177300 Affinity Capture-Western; Reconstituted Complex
WRNH2AFX11332315733840 Affinity Capture-Western; Reconstituted Complex
WRNH2AFX10926815733840 Affinity Capture-Western; Reconstituted Complex
WRNNBN11076315733840 Affinity Capture-Western
WRNNBN11332315733840 Affinity Capture-Western
WRNPCNA11114210871373 12633936 Affinity Capture-Western; Reconstituted Complex
WRNPCNA11332310871373 12633936 Affinity Capture-Western; Reconstituted Complex
WRNPOLB11141917173071 Far Western
WRNPOLB11332317173071 Far Western
WRNPRKDC11157710608806 11889123 Affinity Capture-Western; Biochemical Activity; Protein-peptide
WRNPRKDC11332310608806 11889123 Affinity Capture-Western; Biochemical Activity; Protein-peptide
WRNTERF211287312181313 18212065 Affinity Capture-Western; Co-localization; Reconstituted Complex
WRNTERF211332312181313 18212065 Affinity Capture-Western; Co-localization; Reconstituted Complex
WRNTP5311301011427532 12080066 Affinity Capture-Western; Reconstituted Complex
WRNTP5311332311427532 12080066 Affinity Capture-Western; Reconstituted Complex
XRCC5WRN11335310880505 12177300 Affinity Capture-Western; Reconstituted Complex
XRCC5WRN11332310880505 12177300 Affinity Capture-Western; Reconstituted Complex
WRNIP1WRN12122711301316 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
WRNIP1WRN11332311301316 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
POLR1CWRN11490911971179 Affinity Capture-Western
POLR1CWRN11332311971179 Affinity Capture-Western
MDC1WRN11501414578343 Protein-peptide
MDC1WRN11332314578343 Protein-peptide
CHAF1AWRN11534917173071 Affinity Capture-Western; Co-localization; Far Western
CHAF1AWRN11332317173071 Affinity Capture-Western; Co-localization; Far Western
WDR48WRN12164919615732 Affinity Capture-MS
WDR48WRN11332319615732 Affinity Capture-MS
POT1WRN11332321098121 Phenotypic Enhancement
POT1WRN11741721098121 Phenotypic Enhancement
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
WRNrs1346044 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:109635
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070702-2'