AutismKB 2.0

Annotation Details for WT1


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Basic Information Top
Gene Symbol:WT1 ( AWT1,GUD,NPHS4,WAGR,WIT-2,WT33 )
Gene Full Name: Wilms tumor 1
Band: 11p13
Quick LinksEntrez ID:7490; OMIM: 607102; Uniprot ID:WT1_HUMAN; ENSEMBL ID: ENSG00000184937; HGNC ID: 12796
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus1662794
GO:0005654IDA-nucleoplasm-
GO:0005730IEA-nucleolus-
GO:0005737ISS-cytoplasm-
GO:0005829IDA-cytosol-
GO:0016607IDA-nuclear speck9553041
GO ID Evidence Qualifier GO_term References
GO:0001077ISS-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0003700ISS-transcription factor activity, sequence-specific DNA binding-
GO:0003700NAS-transcription factor activity, sequence-specific DNA binding7862533
GO:0003723IEA-RNA binding-
GO:0005515IPI-protein binding7720589
GO:0008270IDA-zinc ion binding15518539
GO:0010385IDA-double-stranded methylated DNA binding25258363
GO:0043565IDA-sequence-specific DNA binding1662794
GO:0044212IDA-transcription regulatory region DNA binding1332065
GO:0044729IDA-hemi-methylated DNA-binding25258363
GO:0070742IPI-C2H2 zinc finger domain binding8119964
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter7585606
GO:0001570ISS-vasculogenesis-
GO:0001657ISS-ureteric bud development-
GO:0001658IGI-branching involved in ureteric bud morphogenesis10101119
GO:0001822IGI-kidney development11912180
GO:0003156ISS-regulation of animal organ formation-
GO:0006355ISS-regulation of transcription, DNA-templated-
GO:0006355NAS-regulation of transcription, DNA-templated7862533
GO:0006357ISS-regulation of transcription from RNA polymerase II promoter-
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0007281ISS-germ cell development-
GO:0007356ISS-thorax and anterior abdomen determination-
GO:0007507IGI-heart development10101119
GO:0007530IDA-sex determination9815658
GO:0008285IDA-negative regulation of cell proliferation9553041
GO:0008380ISS-RNA splicing-
GO:0008406ISS-gonad development-
GO:0008584IEP-male gonad development17848411
GO:0009888ISS-tissue development-
GO:0030308IDA-negative regulation of cell growth9553041
GO:0030325IGI-adrenal gland development10101119
GO:0030539ISS-male genitalia development-
GO:0030855ISS-epithelial cell differentiation-
GO:0032835IGI-glomerulus development10101119
GO:0032836IMP-glomerular basement membrane development19205749
GO:0035802ISS-adrenal cortex formation-
GO:0043010ISS-camera-type eye development-
GO:0043066IGI-negative regulation of apoptotic process10101119
GO:0045892IDA-negative regulation of transcription, DNA-templated1332065
GO:0045893IDA-positive regulation of transcription, DNA-templated8132626
GO:0045893IGI-positive regulation of transcription, DNA-templated11912180
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0060231ISS-mesenchymal to epithelial transition-
GO:0060421ISS-positive regulation of heart growth-
GO:0060539ISS-diaphragm development-
GO:0060923ISS-cardiac muscle cell fate commitment-
GO:0061032IGI-visceral serous pericardium development10101119
GO:0071320IEP-cellular response to cAMP15961562
GO:0071371IDA-cellular response to gonadotropin stimulus15961562
GO:0072075ISS-metanephric mesenchyme development-
GO:0072112IBA-glomerular visceral epithelial cell differentiation-
GO:0072112ISS-glomerular visceral epithelial cell differentiation-
GO:0072166ISS-posterior mesonephric tubule development-
GO:0072207IEP-metanephric epithelium development7856737
GO:0072284IGI-metanephric S-shaped body morphogenesis10101119
GO:0072302ISS-negative regulation of metanephric glomerular mesangial cell proliferation-
GO:2000020ISS-positive regulation of male gonad development-
GO:2000195ISS-negative regulation of female gonad development-
GO:2001076ISS-positive regulation of metanephric ureteric bud development-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
WT1PAWR1111088943350 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
WT1PAWR1133278943350 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
WT1TP531130108389468 Affinity Capture-Western
WT1TP531133278389468 Affinity Capture-Western
WT1UBE2I1133278798754 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
WT1UBE2I1131778798754 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
U2AF2WT11133279784496 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
U2AF2WT11164669784496 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
WTAPWT111332711001926 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
WTAPWT111495711001926 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:98968
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050420-319'