AutismKB 2.0

Annotation Details for XRCC5


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Basic Information Top
Gene Symbol:XRCC5 ( FLJ39089,KARP-1,KARP1,KU80,KUB2,Ku86,NFIV )
Gene Full Name: X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
Band: 2q35
Quick LinksEntrez ID:7520; OMIM: 194364; Uniprot ID:XRCC5_HUMAN; ENSEMBL ID: ENSG00000079246; HGNC ID: 12833
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000783TAS-nuclear telomere cap complex15100233
GO:0000784IDA-nuclear chromosome, telomeric region10535943
GO:0005576TAS-extracellular region-
GO:0005634IDA-nucleus-
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005730IEA-nucleolus-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane-
GO:0016020IDA-membrane19946888
GO:0032993IDA-protein-DNA complex22504299
GO:0034774TAS-secretory granule lumen-
GO:0043234IDA-protein complex22504299
GO:0043564IDA-Ku70:Ku80 complex20383123
GO:0043564TAS-Ku70:Ku80 complex19188702
GO:0070419IDA-nonhomologous end joining complex20383123
GO ID Evidence Qualifier GO_term References
GO:0003677NAS-DNA binding1537839
GO:0003684IEA-damaged DNA binding-
GO:0003690TAS-double-stranded DNA binding7957065
GO:0003691IDAcontributes_todouble-stranded telomeric DNA binding10409678
GO:0003723IDA-RNA binding22658674
GO:0004003IEA-ATP-dependent DNA helicase activity-
GO:0005515IPI-protein binding8621488
GO:0005524IEA-ATP binding-
GO:0008022IPI-protein C-terminus binding10783163
GO:0008047TAS-enzyme activator activity19188702
GO:0031625IPI-ubiquitin protein ligase binding22266820
GO:0042162IDA-telomeric DNA binding10535943
GO:0042162TAS-telomeric DNA binding12377759
GO:0044212IDA-transcription regulatory region DNA binding18809223
GO:0044877IPI-macromolecular complex binding12377759
GO:0051575IMPcontributes_to5'-deoxyribose-5-phosphate lyase activity20383123
GO ID Evidence Qualifier GO_term References
GO:0000723IEA-telomere maintenance-
GO:0006302IMP-double-strand break repair19581589
GO:0006303IDA-double-strand break repair via nonhomologous end joining26359349
GO:0006303IMP-double-strand break repair via nonhomologous end joining20383123
GO:0006303TAS-double-strand break repair via nonhomologous end joining15824061
GO:0006310IEA-DNA recombination-
GO:0006351IEA-transcription, DNA-templated-
GO:0007420IEA-brain development-
GO:0008283IEA-cell proliferation-
GO:0032204TAS-regulation of telomere maintenance15824061
GO:0032212IMP-positive regulation of telomere maintenance via telomerase19188702
GO:0032481TAS-positive regulation of type I interferon production-
GO:0032508IEA-DNA duplex unwinding-
GO:0042493IEA-response to drug-
GO:0043085TAS-positive regulation of catalytic activity19188702
GO:0043312TAS-neutrophil degranulation-
GO:0045860IDA-positive regulation of protein kinase activity22504299
GO:0045892IMP-negative regulation of transcription, DNA-templated8621488
GO:0048660IMP-regulation of smooth muscle cell proliferation25852083
GO:0050769IEA-positive regulation of neurogenesis-
GO:0051973TAS-positive regulation of telomerase activity19188702
GO:0060218IEA-hematopoietic stem cell differentiation-
GO:0070198TAS-protein localization to chromosome, telomeric region19188702
GO:0071398IEA-cellular response to fatty acid-
GO:0071475IEA-cellular hyperosmotic salinity response-
GO:0071480IDA-cellular response to gamma radiation26359349
GO:0071481IEA-cellular response to X-ray-
GO:0075713TAS-establishment of integrated proviral latency-
GO:1904430IMP-negative regulation of t-circle formation19581589
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
XRCC5PARP110665210400681 16794079 Affinity Capture-Western; Reconstituted Complex
XRCC5PARP111335310400681 16794079 Affinity Capture-Western; Reconstituted Complex
XRCC5BIN111335317671430 Co-purification
XRCC5BIN110677117671430 Co-purification
XRCC5APEX11068258621488 Reconstituted Complex
XRCC5APEX11133538621488 Reconstituted Complex
XRCC5AR10686215640154 Reconstituted Complex
XRCC5AR11335315640154 Reconstituted Complex
XRCC5BARD110705618936166 Affinity Capture-Western
XRCC5BARD111335318936166 Affinity Capture-Western
XRCC5BRCA111335318936166 Affinity Capture-Western; Reconstituted Complex
XRCC5BRCA110714018936166 Affinity Capture-Western; Reconstituted Complex
XRCC5RUNX211335312145306 Affinity Capture-Western
XRCC5RUNX210730812145306 Affinity Capture-Western
XRCC5CD4011335310514012 Reconstituted Complex
XRCC5CD4010739610514012 Reconstituted Complex
XRCC5CHEK110753612756247 Affinity Capture-Western
XRCC5CHEK111335312756247 Affinity Capture-Western
XRCC5DHX910802515723802 Affinity Capture-Western
XRCC5DHX911335315723802 Affinity Capture-Western
XRCC5ESR110840316794079 Affinity Capture-Western
XRCC5ESR111335316794079 Affinity Capture-Western
XRCC5XRCC61088229488450 10207052 10219089 10446239 10984620 12145306 15023334 15520013 Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid
XRCC5XRCC61133539488450 10207052 10219089 10446239 10984620 12145306 15023334 15520013 Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid
XRCC5KAT2A1133539488450 Affinity Capture-Western; Co-fractionation
XRCC5KAT2A1089189488450 Affinity Capture-Western; Co-fractionation
XRCC5H2AFX11335318406329 Affinity Capture-MS; Affinity Capture-Western
XRCC5H2AFX10926818406329 Affinity Capture-MS; Affinity Capture-Western
XRCC5HDLBP11335315723802 Affinity Capture-Western
XRCC5HDLBP10931915723802 Affinity Capture-Western
XRCC5HSF11095309325337 Reconstituted Complex
XRCC5HSF11133539325337 Reconstituted Complex
XRCC5ILF210982117389650 Affinity Capture-Western
XRCC5ILF211335317389650 Affinity Capture-Western
XRCC5PDX110986016166097 Affinity Capture-Western; Reconstituted Complex
XRCC5PDX111335316166097 Affinity Capture-Western; Reconstituted Complex
XRCC5LIG411335315520013 Affinity Capture-Western
XRCC5LIG411016915520013 Affinity Capture-Western
XRCC5MSX211335312145306 Affinity Capture-Western
XRCC5MSX211059412145306 Affinity Capture-Western
XRCC5ORC111104012393188 Affinity Capture-Western
XRCC5ORC111335312393188 Affinity Capture-Western
XRCC5ORC211335312393188 Affinity Capture-Western
XRCC5ORC211104112393188 Affinity Capture-Western
XRCC5PCNA11335311239001 12171929 12393188 Affinity Capture-MS; Affinity Capture-Western
XRCC5PCNA11114211239001 12171929 12393188 Affinity Capture-MS; Affinity Capture-Western
XRCC5PHF111127118385154 Affinity Capture-Western
XRCC5PHF111335318385154 Affinity Capture-Western
XRCC5POLA111141812393188 Affinity Capture-Western
XRCC5POLA111335312393188 Affinity Capture-Western
XRCC5POLR2D11335312393188 Affinity Capture-Western
XRCC5POLR2D11142912393188 Affinity Capture-Western
XRCC5POLR2E11335312393188 Affinity Capture-Western
XRCC5POLR2E11143012393188 Affinity Capture-Western
XRCC5POU2F111335311279128 12393188 Affinity Capture-Western
XRCC5POU2F111144711279128 12393188 Affinity Capture-Western
XRCC5PRIM111154712393188 Affinity Capture-Western
XRCC5PRIM111335312393188 Affinity Capture-Western
XRCC5PRKDC1115779312071 10446239 12393188 15520013 Affinity Capture-Western; Reconstituted Complex
XRCC5PRKDC1133539312071 10446239 12393188 15520013 Affinity Capture-Western; Reconstituted Complex
XRCC5RFC111335312393188 Affinity Capture-Western
XRCC5RFC111191312393188 Affinity Capture-Western
XRCC5SUMO211335319394292 Affinity Capture-MS
XRCC5SUMO211249719394292 Affinity Capture-MS
XRCC5TERF211287315100233 Affinity Capture-Western
XRCC5TERF211335315100233 Affinity Capture-Western
XRCC5TERT11335312377759 Affinity Capture-Western; Reconstituted Complex
XRCC5TERT11287412377759 Affinity Capture-Western; Reconstituted Complex
XRCC5TOP2A11335312393188 Affinity Capture-Western
XRCC5TOP2A11300612393188 Affinity Capture-Western
XRCC5TYK211335310673353 Affinity Capture-Western
XRCC5TYK211314810673353 Affinity Capture-Western
XRCC5VAV111335310673353 Affinity Capture-Western
XRCC5VAV111325210673353 Affinity Capture-Western
XRCC5WRN11335310880505 12177300 Affinity Capture-Western; Reconstituted Complex
XRCC5WRN11332310880505 12177300 Affinity Capture-Western; Reconstituted Complex
XRCC5XRCC411335315520013 Affinity Capture-Western
XRCC5XRCC411335215520013 Affinity Capture-Western
NCOA6XRCC511335310823961 12519782 Affinity Capture-MS
NCOA6XRCC511669110823961 12519782 Affinity Capture-MS
RBM14XRCC511335311443112 Affinity Capture-Western
RBM14XRCC511570011443112 Affinity Capture-Western
NAA15XRCC511335312145306 Affinity Capture-Western
NAA15XRCC512314612145306 Affinity Capture-Western
TERF2IPXRCC511335315100233 Affinity Capture-MS; Affinity Capture-Western
TERF2IPXRCC511994215100233 Affinity Capture-MS; Affinity Capture-Western
H2AFYXRCC511492717158748 Affinity Capture-MS
H2AFYXRCC511335317158748 Affinity Capture-MS
CHD1LXRCC511335319661379 19666485 Affinity Capture-MS
CHD1LXRCC511492919661379 19666485 Affinity Capture-MS
NR1H4XRCC511335319833092 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
NR1H4XRCC511529619833092 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
SIRT6XRCC511960320157594 Affinity Capture-MS; Affinity Capture-Western
SIRT6XRCC511335320157594 Affinity Capture-MS; Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
XRCC5NBN25870115758953 NBS1 interacts with XRCC5 (Ku80).
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:104517
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-041008-108'