AutismKB 2.0

Annotation Details for YWHAB


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Basic Information Top
Gene Symbol:YWHAB ( GW128,HS1,KCIP-1,YWHAA )
Gene Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
Band: 20q13.12
Quick LinksEntrez ID:7529; OMIM: 601289; Uniprot ID:1433B_HUMAN; ENSEMBL ID: ENSG00000166913; HGNC ID: 12849
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IEA-nucleus-
GO:0005737IDA-cytoplasm10869435
GO:0005739IEA-mitochondrion-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005925IDA-focal adhesion21423176
GO:0016020IDA-membrane19946888
GO:0017053IEA-transcriptional repressor complex-
GO:0030659TAS-cytoplasmic vesicle membrane-
GO:0042470IEA-melanosome-
GO:0043234IEA-protein complex-
GO:0048471IDA-perinuclear region of cytoplasm12963375
GO:0070062IDA-extracellular exosome19199708
GO ID Evidence Qualifier GO_term References
GO:0003714IEA-transcription corepressor activity-
GO:0005515IPI-protein binding7644510
GO:0008022IEA-protein C-terminus binding-
GO:0019899IPI-enzyme binding17255105
GO:0019904IPI-protein domain specific binding11984006
GO:0032403IEA-protein complex binding-
GO:0042826IPI-histone deacetylase binding10869435
GO:0045296IDA-cadherin binding25468996
GO:0050815IPI-phosphoserine residue binding10869435
GO:0051219IPI-phosphoprotein binding10869435
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0006605IEA-protein targeting-
GO:0016032IEA-viral process-
GO:0035308IDA-negative regulation of protein dephosphorylation17255105
GO:0035329TAS-hippo signaling-
GO:0043085IDA-positive regulation of catalytic activity17255105
GO:0043488TAS-regulation of mRNA stability-
GO:0045744IMP-negative regulation of G-protein coupled receptor protein signaling pathway21224381
GO:0045892IEA-negative regulation of transcription, DNA-templated-
GO:0051220IDA-cytoplasmic sequestering of protein10869435
GO:0051291IEA-protein heterooligomerization-
GO:0061024TAS-membrane organization-
GO:1900740TAS-positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
YWHABBAD1070489369453 Two-hybrid
YWHABBAD1133619369453 Two-hybrid
YWHABBRAF10714110931830 17353931 Affinity Capture-MS; Affinity Capture-Western
YWHABBRAF11336110931830 17353931 Affinity Capture-MS; Affinity Capture-Western
YWHABCAMK2A11336112619878 Biochemical Activity
YWHABCAMK2A10726512619878 Biochemical Activity
YWHABCAMK2B10726612619878 Biochemical Activity
YWHABCAMK2B11336112619878 Biochemical Activity
YWHABCBL1073159367879 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHABCBL1133619367879 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHABCDC25A1074287644510 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHABCDC25A1133617644510 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHABCDC25B1133617644510 10713667 Reconstituted Complex; Two-hybrid
YWHABCDC25B1074297644510 10713667 Reconstituted Complex; Two-hybrid
YWHABCDC25C11336115284440 Two-hybrid
YWHABCDC25C10743015284440 Two-hybrid
YWHABLYST10755211984006 Two-hybrid
YWHABLYST11336111984006 Two-hybrid
YWHABCSNK2A110784117353931 Affinity Capture-MS
YWHABCSNK2A111336117353931 Affinity Capture-MS
YWHABEMD11336117620012 Affinity Capture-MS
YWHABEMD10832517620012 Affinity Capture-MS
YWHABFOXO311336120562859 Affinity Capture-MS
YWHABFOXO310859820562859 Affinity Capture-MS
YWHABIGF1R1097019581554 Reconstituted Complex
YWHABIGF1R1133619581554 Reconstituted Complex
YWHABING110983316581770 Reconstituted Complex
YWHABING111336116581770 Reconstituted Complex
YWHABIRS11133619422753 Reconstituted Complex
YWHABIRS11098749422753 Reconstituted Complex
YWHABITGB111336111313964 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHABITGB110989411313964 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHABKCNK310997812437930 Affinity Capture-Western; Protein-peptide
YWHABKCNK311336112437930 Affinity Capture-Western; Protein-peptide
YWHABKIF5B11000017353931 Affinity Capture-MS
YWHABKIF5B11336117353931 Affinity Capture-MS
YWHABKLC111002917353931 Affinity Capture-MS
YWHABKLC111336117353931 Affinity Capture-MS
YWHABMAPT11030810840038 12176984 Affinity Capture-Western
YWHABMAPT11336110840038 12176984 Affinity Capture-Western
YWHABMARK311336117353931 Affinity Capture-MS
YWHABMARK311031017353931 Affinity Capture-MS
YWHABMDM411336116227609 16511560 Affinity Capture-Western
YWHABMDM411035916227609 16511560 Affinity Capture-Western
YWHABMLLT411336117353931 Affinity Capture-MS
YWHABMLLT411044717353931 Affinity Capture-MS
YWHABPI4KB11336117353931 Affinity Capture-MS
YWHABPI4KB11131617353931 Affinity Capture-MS
YWHABPRKCZ11336110620507 Affinity Capture-Western; Biochemical Activity
YWHABPRKCZ11157610620507 Affinity Capture-Western; Biochemical Activity
YWHABMAPK711158414679215 Affinity Capture-Western; Reconstituted Complex
YWHABMAPK711336114679215 Affinity Capture-Western; Reconstituted Complex
YWHABPTPN31133619341175 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHABPTPN31117409341175 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHABRAF11118317644510 8702721 10620507 10848612 12360521 12620389 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHABRAF11133617644510 8702721 10620507 10848612 12360521 12620389 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHABRASGRF11133619543386 Reconstituted Complex
YWHABRASGRF11118589543386 Reconstituted Complex
YWHABRGS311193010862767 Affinity Capture-Western
YWHABRGS311336110862767 Affinity Capture-Western
YWHABRPS6KA111336112618428 Affinity Capture-Western; Reconstituted Complex
YWHABRPS6KA111210912618428 Affinity Capture-Western; Reconstituted Complex
YWHABTESK111287511555644 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHABTESK111336111555644 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHABTNFAIP31133618702721 19615732 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHABTNFAIP31129838702721 19615732 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHABTSC111309912176984 Affinity Capture-Western
YWHABTSC111336112176984 Affinity Capture-Western
YWHABTSC211310012176984 12364343 12468542 12582162 16636147 Affinity Capture-Western; Two-hybrid
YWHABTSC211336112176984 12364343 12468542 12582162 16636147 Affinity Capture-Western; Two-hybrid
YWHABUCP211319810785390 Two-hybrid
YWHABUCP211336110785390 Two-hybrid
YWHABUCP311319910785390 Two-hybrid
YWHABUCP311336110785390 Two-hybrid
YWHABWEE111336110775038 Affinity Capture-Western; Two-hybrid
YWHABWEE111330310775038 Affinity Capture-Western; Two-hybrid
PRPF6YWHAB11336110848612 Two-hybrid
PRPF6YWHAB11729810848612 Two-hybrid
HDAC5YWHAB11336110869435 Affinity Capture-Western
HDAC5YWHAB11533110869435 Affinity Capture-Western
HDAC4YWHAB11336110869435 10958686 Affinity Capture-Western
HDAC4YWHAB11510610869435 10958686 Affinity Capture-Western
TESK2YWHAB11336111555644 Two-hybrid
TESK2YWHAB11568911555644 Two-hybrid
ZFP36YWHAB11336111886850 Affinity Capture-Western
ZFP36YWHAB11337011886850 Affinity Capture-Western
EPB41L3YWHAB11336111996670 17353931 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
EPB41L3YWHAB11675311996670 17353931 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MLXIPYWHAB11336112446771 Affinity Capture-Western; Two-hybrid
MLXIPYWHAB11654412446771 Affinity Capture-Western; Two-hybrid
DENND4AYWHAB11336117353931 Affinity Capture-MS
DENND4AYWHAB11555217353931 Affinity Capture-MS
NCKAP1YWHAB11336117353931 Affinity Capture-MS
NCKAP1YWHAB11600317353931 Affinity Capture-MS
AKAP13YWHAB11336117353931 Affinity Capture-MS
AKAP13YWHAB11638317353931 Affinity Capture-MS
FOXK1YWHAB11336117353931 Affinity Capture-MS
FOXK1YWHAB12876917353931 Affinity Capture-MS
MPRIPYWHAB11336117353931 Affinity Capture-MS
MPRIPYWHAB11677617353931 Affinity Capture-MS
LARP1YWHAB11336117353931 Affinity Capture-MS
LARP1YWHAB11694717353931 Affinity Capture-MS
SRRM2YWHAB11336117353931 Affinity Capture-MS
SRRM2YWHAB11707117353931 Affinity Capture-MS
OSBPL3YWHAB11336117353931 Affinity Capture-MS
OSBPL3YWHAB11749717353931 Affinity Capture-MS
RAI14YWHAB11336117353931 Affinity Capture-MS
RAI14YWHAB11752617353931 Affinity Capture-MS
RABGEF1YWHAB11336117353931 Affinity Capture-MS
RABGEF1YWHAB11815417353931 Affinity Capture-MS
FRYLYWHAB11336117353931 Affinity Capture-MS
FRYLYWHAB13013417353931 Affinity Capture-MS
RACGAP1YWHAB11336117353931 Affinity Capture-MS
RACGAP1YWHAB11889217353931 Affinity Capture-MS
SAMD4BYWHAB11336117353931 Affinity Capture-MS
SAMD4BYWHAB12040717353931 Affinity Capture-MS
FAM82A2YWHAB11336117353931 Affinity Capture-MS
FAM82A2YWHAB12047617353931 Affinity Capture-MS
PARD3YWHAB11336117353931 Affinity Capture-MS
PARD3YWHAB12113417353931 Affinity Capture-MS
CGNYWHAB11336117353931 Affinity Capture-MS
CGNYWHAB12158917353931 Affinity Capture-MS
EDC3YWHAB11336117353931 Affinity Capture-MS
EDC3YWHAB12314417353931 Affinity Capture-MS
IRS2YWHAB11336117353931 Affinity Capture-MS
IRS2YWHAB11420917353931 Affinity Capture-MS
USP8YWHAB11336117353931 Affinity Capture-MS
USP8YWHAB11455517353931 Affinity Capture-MS
TJP2YWHAB11336117353931 Affinity Capture-MS
TJP2YWHAB11480917353931 Affinity Capture-MS
KIF23YWHAB11336117353931 Affinity Capture-MS
KIF23YWHAB11487317353931 Affinity Capture-MS
SLC4A7YWHAB11336117353931 Affinity Capture-MS
SLC4A7YWHAB11487617353931 Affinity Capture-MS
USP43YWHAB11336119615732 Affinity Capture-MS
USP43YWHAB12588419615732 Affinity Capture-MS
USP32YWHAB11336119615732 Affinity Capture-MS
USP32YWHAB12418919615732 Affinity Capture-MS
WDR20YWHAB11336119615732 Affinity Capture-MS
WDR20YWHAB12488419615732 Affinity Capture-MS
YWHAEYWHAB11336120936779 Two-hybrid
YWHAEYWHAB11336320936779 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
YWHABCDC25A3005977644510 14-3-3-beta interacts with cdc25A.
YWHABCDC25B3005987644510 14-3-3-beta interacts with cdc25B.
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
YWHABrs2425669, rs2425672 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1891917
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-6583'