AutismKB 2.0

Annotation Details for YWHAE


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Basic Information Top
Gene Symbol:YWHAE ( 14-3-3E,FLJ45465,FLJ53559,KCIP-1,MDCR,MDS )
Gene Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
Band: 17p13.3
Quick LinksEntrez ID:7531; OMIM: 605066; Uniprot ID:1433E_HUMAN; ENSEMBL ID: ENSG00000108953; HGNC ID: 12851
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus12917326
GO:0005737IDA-cytoplasm12917326
GO:0005739IEA-mitochondrion-
GO:0005829TAS-cytosol-
GO:0005871IEA-kinesin complex-
GO:0005886IDAcolocalizes_withplasma membrane18029012
GO:0005925IDA-focal adhesion21423176
GO:0016020IDA-membrane19946888
GO:0030424IEA-axon-
GO:0030659TAS-cytoplasmic vesicle membrane-
GO:0042470IEA-melanosome-
GO:0070062IDA-extracellular exosome19056867
GO:0090724IEA-central region of growth cone-
GO ID Evidence Qualifier GO_term References
GO:0003723IDA-RNA binding22658674
GO:0005246IDA-calcium channel regulator activity18029012
GO:0005515IPI-protein binding1266503
GO:0015459IDA-potassium channel regulator activity11953308
GO:0017112TAS-Rab guanyl-nucleotide exchange factor activity-
GO:0019899IPI-enzyme binding10788521
GO:0019904IEA-protein domain specific binding-
GO:0023026IDA-MHC class II protein complex binding20458337
GO:0031625IPI-ubiquitin protein ligase binding19725078
GO:0042826IPI-histone deacetylase binding10869435
GO:0044325IPI-ion channel binding11953308
GO:0045296IDA-cadherin binding25468996
GO:0046982IPI-protein heterodimerization activity11953308
GO:0050815IPI-phosphoserine residue binding10869435
GO:0051219IPI-phosphoprotein binding10869435
GO ID Evidence Qualifier GO_term References
GO:0000086TAS-G2/M transition of mitotic cell cycle-
GO:0000165IDA-MAPK cascade12917326
GO:0001764IEA-neuron migration-
GO:0003064NAS-regulation of heart rate by hormone11953308
GO:0006605IEA-protein targeting-
GO:0016032IEA-viral process-
GO:0021762IEP-substantia nigra development22926577
GO:0021766IEA-hippocampus development-
GO:0021987IEA-cerebral cortex development-
GO:0034605IDA-cellular response to heat12917326
GO:0035329TAS-hippo signaling-
GO:0035556TAS-intracellular signal transduction7644510
GO:0043154TAS-negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0046827IDA-positive regulation of protein export from nucleus12917326
GO:0051480IDA-regulation of cytosolic calcium ion concentration18029012
GO:0060306IDA-regulation of membrane repolarization11953308
GO:0061024TAS-membrane organization-
GO:0086013IC-membrane repolarization during cardiac muscle cell action potential11953308
GO:0086091IC-regulation of heart rate by cardiac conduction11953308
GO:0097711TAS-ciliary basal body docking-
GO:1900034TAS-regulation of cellular response to heat-
GO:1900740TAS-positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway-
GO:1901016IDA-regulation of potassium ion transmembrane transporter activity11953308
GO:1901020IDA-negative regulation of calcium ion transmembrane transporter activity18029012
GO:1902309IDA-negative regulation of peptidyl-serine dephosphorylation11953308
GO:1905913IDA-negative regulation of calcium ion export from cell18029012
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
YWHAEARAF11336320936779 Two-hybrid
YWHAEARAF10686420936779 Two-hybrid
YWHAEBAD1133639369453 20936779 Two-hybrid
YWHAEBAD1070489369453 20936779 Two-hybrid
YWHAECDC25A1133637644510 Two-hybrid
YWHAECDC25A1074287644510 Two-hybrid
YWHAECDC25B1133637644510 10713667 Reconstituted Complex; Two-hybrid
YWHAECDC25B1074297644510 10713667 Reconstituted Complex; Two-hybrid
YWHAECDC25C11336310330186 Affinity Capture-Western
YWHAECDC25C10743010330186 Affinity Capture-Western
YWHAEEMD11336317620012 Affinity Capture-MS
YWHAEEMD10832517620012 Affinity Capture-MS
YWHAEFOXO311336320562859 Affinity Capture-MS
YWHAEFOXO310859820562859 Affinity Capture-MS
YWHAEHIVEP211336320936779 Two-hybrid
YWHAEHIVEP210934420936779 Two-hybrid
YWHAEIGF1R1133639111084 Reconstituted Complex; Two-hybrid
YWHAEIGF1R1097019111084 Reconstituted Complex; Two-hybrid
YWHAEING111336316581770 Reconstituted Complex
YWHAEING110983316581770 Reconstituted Complex
YWHAEIRS11133639111084 Reconstituted Complex; Two-hybrid
YWHAEIRS11098749111084 Reconstituted Complex; Two-hybrid
YWHAEKCNH211336311953308 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHAEKCNH210995911953308 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHAELRMP11336320936779 Two-hybrid
YWHAELRMP11021320936779 Two-hybrid
YWHAEMDM411336316227609 16511560 Affinity Capture-Western
YWHAEMDM411035916227609 16511560 Affinity Capture-Western
YWHAEMAP3K11103789452471 Reconstituted Complex
YWHAEMAP3K11133639452471 Reconstituted Complex
YWHAEMAP3K31103799452471 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHAEMAP3K31133639452471 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHAEMAP3K101133639427749 Affinity Capture-Western
YWHAEMAP3K101104409427749 Affinity Capture-Western
YWHAECOX211061620936779 Two-hybrid
YWHAECOX211336320936779 Two-hybrid
YWHAEMYH1011336320936779 Two-hybrid
YWHAEMYH1011071320936779 Two-hybrid
YWHAEPNLIP11336320936779 Two-hybrid
YWHAEPNLIP11140720936779 Two-hybrid
YWHAEMAPK711336314679215 Two-hybrid
YWHAEMAPK711158414679215 Two-hybrid
YWHAERAF11133637644510 8702721 Affinity Capture-Western; Two-hybrid
YWHAERAF11118317644510 8702721 Affinity Capture-Western; Two-hybrid
YWHAESSFA211336320936779 Two-hybrid
YWHAESSFA211262220936779 Two-hybrid
YWHAESYN211272010358015 Two-hybrid
YWHAESYN211336310358015 Two-hybrid
YWHAETGFB111336311172812 Affinity Capture-Western; Reconstituted Complex
YWHAETGFB111289811172812 Affinity Capture-Western; Reconstituted Complex
YWHAETNFAIP31133638702721 Affinity Capture-Western
YWHAETNFAIP31129838702721 Affinity Capture-Western
YWHAETOP2A11300610788521 Affinity Capture-Western
YWHAETOP2A11336310788521 Affinity Capture-Western
YWHAEYWHAB11336120936779 Two-hybrid
YWHAEYWHAB11336320936779 Two-hybrid
MAP3K2YWHAE1159699452471 Reconstituted Complex
MAP3K2YWHAE1133639452471 Reconstituted Complex
REM1YWHAE11336310441394 Far Western
REM1YWHAE11878110441394 Far Western
HDAC5YWHAE11533110869435 Affinity Capture-Western
HDAC5YWHAE11336310869435 Affinity Capture-Western
HDAC4YWHAE11336310869435 11504882 20936779 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HDAC4YWHAE11510610869435 11504882 20936779 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NGFRAP1YWHAE11336311278287 Affinity Capture-Western; Reconstituted Complex
NGFRAP1YWHAE11795611278287 Affinity Capture-Western; Reconstituted Complex
NDEL1YWHAE11336312796778 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NDEL1YWHAE12352712796778 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HDAC9YWHAE11336315166223 20936779 Affinity Capture-Western; Two-hybrid
HDAC9YWHAE11508315166223 20936779 Affinity Capture-Western; Two-hybrid
SRRM2YWHAE11336316159877 Affinity Capture-MS
SRRM2YWHAE11707116159877 Affinity Capture-MS
SORBS2YWHAE11336316189514 Two-hybrid
SORBS2YWHAE11404716189514 Two-hybrid
GRAP2YWHAE11336316189514 Two-hybrid
GRAP2YWHAE11479916189514 Two-hybrid
GPRIN2YWHAE11336316189514 Two-hybrid
GPRIN2YWHAE11507016189514 Two-hybrid
POLR3HYWHAE11336317643375 Affinity Capture-MS
POLR3HYWHAE12814717643375 Affinity Capture-MS
USP43YWHAE12588419615732 Affinity Capture-MS
USP43YWHAE11336319615732 Affinity Capture-MS
HDAC7YWHAE11336320224040 Affinity Capture-MS; Affinity Capture-Western
HDAC7YWHAE11961320224040 Affinity Capture-MS; Affinity Capture-Western
FAN1YWHAE11336320603015 Affinity Capture-MS
FAN1YWHAE11657320603015 Affinity Capture-MS
CHAF1AYWHAE11336320936779 Two-hybrid
CHAF1AYWHAE11534920936779 Two-hybrid
CAP2YWHAE11336320936779 Two-hybrid
CAP2YWHAE11574920936779 Two-hybrid
YWHAQYWHAE11616820936779 Two-hybrid
YWHAQYWHAE11336320936779 Two-hybrid
RAP1GAP2YWHAE11673220936779 Two-hybrid
RAP1GAP2YWHAE11336320936779 Two-hybrid
SH3BP4YWHAE11336320936779 Two-hybrid
SH3BP4YWHAE11719420936779 Two-hybrid
WWTR1YWHAE11336320936779 Two-hybrid
WWTR1YWHAE11743420936779 Two-hybrid
ANKHD1-EIF4EBP3YWHAE11336320936779 Two-hybrid
ANKHD1-EIF4EBP3YWHAE13569820936779 Two-hybrid
FAM13BYWHAE11336320936779 Two-hybrid
FAM13BYWHAE11945720936779 Two-hybrid
MSL2YWHAE11336320936779 Two-hybrid
MSL2YWHAE12046720936779 Two-hybrid
ZNF839YWHAE11336320936779 Two-hybrid
ZNF839YWHAE12089320936779 Two-hybrid
RASAL3YWHAE11336320936779 Two-hybrid
RASAL3YWHAE12234820936779 Two-hybrid
WNK1YWHAE11336320936779 Two-hybrid
WNK1YWHAE12240320936779 Two-hybrid
YWHAGYWHAE11336420936779 Two-hybrid
YWHAGYWHAE11336320936779 Two-hybrid
YWHAHYWHAE11336320936779 Two-hybrid
YWHAHYWHAE11336520936779 Two-hybrid
YWHAZYWHAE11336620936779 Two-hybrid
YWHAZYWHAE11336320936779 Two-hybrid
C16orf48YWHAE11336320936779 Two-hybrid
C16orf48YWHAE12387520936779 Two-hybrid
TBC1D3FYWHAE11336320936779 Two-hybrid
TBC1D3FYWHAE12395220936779 Two-hybrid
CGNL1YWHAE11336320936779 Two-hybrid
CGNL1YWHAE12438420936779 Two-hybrid
CCDC45YWHAE11336320936779 Two-hybrid
CCDC45YWHAE12476220936779 Two-hybrid
KIAA0232YWHAE11336320936779 Two-hybrid
KIAA0232YWHAE11512220936779 Two-hybrid
TLK1YWHAE11336320936779 Two-hybrid
TLK1YWHAE11520620936779 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
YWHAECDC25A3005967644510 14-3-3-epsilon interacts with cdc25A.
YWHAECDC25B3005997644510 14-3-3-epsilon interacts with cdc25B.
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
YWHAErs11655548, rs12452627, rs1873827, rs2131431, rs28365859, rs34041110, rs3752826, rs7214541, rs7224258, rs8064578, rs9393 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:894689
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-779'