AutismKB 2.0

Annotation Details for YWHAZ


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Basic Information Top
Gene Symbol:YWHAZ ( 14-3-3-zeta,KCIP-1,MGC111427,MGC126532,MGC138156,YWHAD )
Gene Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
Band: 8q22.3
Quick LinksEntrez ID:7534; OMIM: 601288; Uniprot ID:1433Z_HUMAN; ENSEMBL ID: ENSG00000164924; HGNC ID: 12855
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005615IDA-extracellular space16502470
GO:0005634IDA-nucleus21630459
GO:0005654TAS-nucleoplasm-
GO:0005737TAS-cytoplasm16130169
GO:0005739IEA-mitochondrion-
GO:0005829TAS-cytosol-
GO:0005925IDA-focal adhesion21423176
GO:0030659TAS-cytoplasmic vesicle membrane-
GO:0031982IDA-vesicle19190083
GO:0042470IEA-melanosome-
GO:0070062IDA-extracellular exosome19056867
GO:0072562IDA-blood microparticle22516433
GO ID Evidence Qualifier GO_term References
GO:0003723IDA-RNA binding22658674
GO:0005515IPI-protein binding7935795
GO:0008134IPI-transcription factor binding16114898
GO:0019901IPI-protein kinase binding10102273
GO:0019904IEA-protein domain specific binding-
GO:0031625IPI-ubiquitin protein ligase binding19725078
GO:0042802IPI-identical protein binding16376338
GO:0044325IPI-ion channel binding18029012
GO:0045296IDA-cadherin binding25468996
GO ID Evidence Qualifier GO_term References
GO:0006605IEA-protein targeting-
GO:0007165TAS-signal transduction16130169
GO:0030168TAS-platelet activation-
GO:0043066TAS-negative regulation of apoptotic process16130169
GO:0043488TAS-regulation of mRNA stability-
GO:0051683IMP-establishment of Golgi localization20332113
GO:0061024TAS-membrane organization-
GO:0090168IMP-Golgi reassembly20332113
GO:1900740TAS-positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
YWHAZAANAT10653311336675 Co-crystal Structure; Co-purification
YWHAZAANAT11336611336675 Co-crystal Structure; Co-purification
YWHAZAKT111336611956222 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
YWHAZAKT110671011956222 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
YWHAZARAF11336620936779 Two-hybrid
YWHAZARAF10686420936779 Two-hybrid
YWHAZBAD10704811410287 20936779 Reconstituted Complex; Two-hybrid
YWHAZBAD11336611410287 20936779 Reconstituted Complex; Two-hybrid
YWHAZBRAF10714117353931 Affinity Capture-MS
YWHAZBRAF11336617353931 Affinity Capture-MS
YWHAZCBL1133669367879 Two-hybrid
YWHAZCBL1073159367879 Two-hybrid
YWHAZCDC25A10742811912208 Two-hybrid
YWHAZCDC25A11336611912208 Two-hybrid
YWHAZCDC25B11336610713667 Reconstituted Complex; Two-hybrid
YWHAZCDC25B10742910713667 Reconstituted Complex; Two-hybrid
YWHAZLYST10755211984006 Reconstituted Complex
YWHAZLYST11336611984006 Reconstituted Complex
YWHAZCSF2RB10782610477722 Affinity Capture-Western; Reconstituted Complex
YWHAZCSF2RB11336610477722 Affinity Capture-Western; Reconstituted Complex
YWHAZDFFA11336617353931 Affinity Capture-MS
YWHAZDFFA10804017353931 Affinity Capture-MS
YWHAZEPB41L210835120936779 Two-hybrid
YWHAZEPB41L211336620936779 Two-hybrid
YWHAZFOXO110859711237865 Affinity Capture-Western
YWHAZFOXO111336611237865 Affinity Capture-Western
YWHAZFOXO310859810102273 Affinity Capture-Western
YWHAZFOXO311336610102273 Affinity Capture-Western
YWHAZXRCC610882216169070 Two-hybrid
YWHAZXRCC611336616169070 Two-hybrid
YWHAZGP1BA1090738631758 9454760 10627461 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHAZGP1BA1133668631758 9454760 10627461 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHAZGP1BB1090748034572 9454760 10627461 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHAZGP1BB1133668034572 9454760 10627461 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHAZHIVEP211336620936779 Two-hybrid
YWHAZHIVEP210934420936779 Two-hybrid
YWHAZHMGN110939312215538 Affinity Capture-Western; Reconstituted Complex
YWHAZHMGN111336612215538 Affinity Capture-Western; Reconstituted Complex
YWHAZHNRNPL11336617353931 Affinity Capture-MS
YWHAZHNRNPL10943217353931 Affinity Capture-MS
YWHAZIL9R10979510642536 Affinity Capture-Western; Two-hybrid
YWHAZIL9R11336610642536 Affinity Capture-Western; Two-hybrid
YWHAZING110983316581770 Reconstituted Complex
YWHAZING111336616581770 Reconstituted Complex
YWHAZINPP5A1098449398266 Reconstituted Complex
YWHAZINPP5A1133669398266 Reconstituted Complex
YWHAZKIF5B11000017353931 Affinity Capture-MS
YWHAZKIF5B11336617353931 Affinity Capture-MS
YWHAZKLC111002917353931 Affinity Capture-MS
YWHAZKLC111336617353931 Affinity Capture-MS
YWHAZLCP211336620936779 Two-hybrid
YWHAZLCP211012920936779 Two-hybrid
YWHAZLIMK111336612323073 Reconstituted Complex; Two-hybrid
YWHAZLIMK111017212323073 Reconstituted Complex; Two-hybrid
YWHAZLRMP11021320936779 Two-hybrid
YWHAZLRMP11336620936779 Two-hybrid
YWHAZMAPT11030810840038 Affinity Capture-Western; Reconstituted Complex
YWHAZMAPT11336610840038 Affinity Capture-Western; Reconstituted Complex
YWHAZMEF2C11037220936779 Two-hybrid
YWHAZMEF2C11336620936779 Two-hybrid
YWHAZMAP3K411038020936779 Two-hybrid
YWHAZMAP3K411336620936779 Two-hybrid
YWHAZMAP3K511336610411906 Affinity Capture-Western
YWHAZMAP3K511038110411906 Affinity Capture-Western
YWHAZMGMT11041116226712 Affinity Capture-MS
YWHAZMGMT11336616226712 Affinity Capture-MS
YWHAZMYH911336620936779 Two-hybrid
YWHAZMYH911071220936779 Two-hybrid
YWHAZNFATC411336610611249 Reconstituted Complex
YWHAZNFATC411084910611249 Reconstituted Complex
YWHAZPAK111109520936779 Two-hybrid
YWHAZPAK111336620936779 Two-hybrid
YWHAZCDK161111549197417 Two-hybrid
YWHAZCDK161133669197417 Two-hybrid
YWHAZPRKCA11336611950841 Affinity Capture-Western
YWHAZPRKCA11156411950841 Affinity Capture-Western
YWHAZPRKCD11156611950841 Affinity Capture-Western
YWHAZPRKCD11336611950841 Affinity Capture-Western
YWHAZPRKCE11336611950841 Affinity Capture-Western
YWHAZPRKCE11156711950841 Affinity Capture-Western
YWHAZPRKCI11336612893243 Reconstituted Complex
YWHAZPRKCI11157012893243 Reconstituted Complex
YWHAZPRKD111336612893243 Reconstituted Complex
YWHAZPRKD111157312893243 Reconstituted Complex
YWHAZPRKCZ11336610620507 12893243 Biochemical Activity; Reconstituted Complex
YWHAZPRKCZ11157610620507 12893243 Biochemical Activity; Reconstituted Complex
YWHAZMAP2K511336620936779 Two-hybrid
YWHAZMAP2K511159320936779 Two-hybrid
YWHAZRAF11133667628630 9261098 10611249 10620507 10887173 Affinity Capture-Western; Reconstituted Complex
YWHAZRAF11118317628630 9261098 10611249 10620507 10887173 Affinity Capture-Western; Reconstituted Complex
YWHAZRGS311336611985497 Affinity Capture-Western
YWHAZRGS311193011985497 Affinity Capture-Western
YWHAZRPL3111336617353931 Affinity Capture-MS
YWHAZRPL3111207917353931 Affinity Capture-MS
YWHAZRRAD11336610441394 Affinity Capture-Western
YWHAZRRAD11215010441394 Affinity Capture-Western
YWHAZTRA2B11233217353931 Affinity Capture-MS
YWHAZTRA2B11336617353931 Affinity Capture-MS
YWHAZSSFA211336620936779 Two-hybrid
YWHAZSSFA211262220936779 Two-hybrid
YWHAZSYN211336610358015 Two-hybrid
YWHAZSYN211272010358015 Two-hybrid
YWHAZTERT11336610835362 Two-hybrid
YWHAZTERT11287410835362 Two-hybrid
YWHAZTNFAIP31133668702721 9299557 20936779 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHAZTNFAIP31129838702721 9299557 20936779 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHAZTNS111336620936779 Two-hybrid
YWHAZTNS111299920936779 Two-hybrid
YWHAZTP531130109620776 Affinity Capture-Western; Reconstituted Complex
YWHAZTP531133669620776 Affinity Capture-Western; Reconstituted Complex
YWHAZTPH11133668101440 Reconstituted Complex
YWHAZTPH11130198101440 Reconstituted Complex
YWHAZTSC111336612176984 Two-hybrid
YWHAZTSC111309912176984 Two-hybrid
YWHAZTSC211310012176984 Reconstituted Complex; Two-hybrid
YWHAZTSC211336612176984 Reconstituted Complex; Two-hybrid
YWHAZUCP211319810785390 Two-hybrid
YWHAZUCP211336610785390 Two-hybrid
YWHAZUCP311319910785390 Two-hybrid
YWHAZUCP311336610785390 Two-hybrid
YWHAZVIM11336610887173 Affinity Capture-Western; Reconstituted Complex
YWHAZVIM11327210887173 Affinity Capture-Western; Reconstituted Complex
YWHAZYWHAE11336620936779 Two-hybrid
YWHAZYWHAE11336320936779 Two-hybrid
BCAR1YWHAZ11336610026197 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BCAR1YWHAZ11493410026197 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
REM1YWHAZ11336610441394 Affinity Capture-Western; Far Western; Reconstituted Complex
REM1YWHAZ11878110441394 Affinity Capture-Western; Far Western; Reconstituted Complex
YWHAZYWHAZ11336610887173 20936779 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HDAC4YWHAZ11336611504882 Reconstituted Complex
HDAC4YWHAZ11510611504882 Reconstituted Complex
KIAA1377YWHAZ12161716169070 Two-hybrid
KIAA1377YWHAZ11336616169070 Two-hybrid
PAK4YWHAZ11336617353931 Affinity Capture-MS
PAK4YWHAZ11558617353931 Affinity Capture-MS
NCKAP1YWHAZ11336617353931 Affinity Capture-MS
NCKAP1YWHAZ11600317353931 Affinity Capture-MS
EPB41L3YWHAZ11675317353931 Affinity Capture-MS
EPB41L3YWHAZ11336617353931 Affinity Capture-MS
C22orf9YWHAZ11336617353931 Affinity Capture-MS
C22orf9YWHAZ11690417353931 Affinity Capture-MS
LARP1YWHAZ11336617353931 Affinity Capture-MS
LARP1YWHAZ11694717353931 Affinity Capture-MS
SF3B1YWHAZ11336617353931 Affinity Capture-MS
SF3B1YWHAZ11701717353931 Affinity Capture-MS
RAI14YWHAZ11336617353931 Affinity Capture-MS
RAI14YWHAZ11752617353931 Affinity Capture-MS
SAMD4BYWHAZ12040717353931 Affinity Capture-MS
SAMD4BYWHAZ11336617353931 Affinity Capture-MS
RALGPS2YWHAZ12041317353931 Affinity Capture-MS
RALGPS2YWHAZ11336617353931 Affinity Capture-MS
NADKYWHAZ11336617353931 Affinity Capture-MS
NADKYWHAZ12240817353931 Affinity Capture-MS
EDC3YWHAZ11336617353931 Affinity Capture-MS
EDC3YWHAZ12314417353931 Affinity Capture-MS
PABPC4YWHAZ11336617353931 Affinity Capture-MS
PABPC4YWHAZ11429617353931 Affinity Capture-MS
KLC4YWHAZ11336617353931 Affinity Capture-MS
KLC4YWHAZ12464817353931 Affinity Capture-MS
USP8YWHAZ11455517353931 Affinity Capture-MS
USP8YWHAZ11336617353931 Affinity Capture-MS
NOLC1YWHAZ11336617353931 Affinity Capture-MS
NOLC1YWHAZ11465417353931 Affinity Capture-MS
TJP2YWHAZ11480917353931 Affinity Capture-MS
TJP2YWHAZ11336617353931 Affinity Capture-MS
MEPCEYWHAZ11336617643375 Affinity Capture-MS
MEPCEYWHAZ12112217643375 Affinity Capture-MS
HDAC7YWHAZ11336620224040 Affinity Capture-MS; Affinity Capture-Western
HDAC7YWHAZ11961320224040 Affinity Capture-MS; Affinity Capture-Western
FAN1YWHAZ11657320603015 Affinity Capture-MS
FAN1YWHAZ11336620603015 Affinity Capture-MS
CHAF1AYWHAZ11336620936779 Two-hybrid
CHAF1AYWHAZ11534920936779 Two-hybrid
MPHOSPH9YWHAZ11336620936779 Two-hybrid
MPHOSPH9YWHAZ11549320936779 Two-hybrid
COPS5YWHAZ11336620936779 Two-hybrid
COPS5YWHAZ11618320936779 Two-hybrid
SYNPOYWHAZ11647420936779 Two-hybrid
SYNPOYWHAZ11336620936779 Two-hybrid
SYNPO2YWHAZ11336620936779 Two-hybrid
SYNPO2YWHAZ12810520936779 Two-hybrid
RAP1GAP2YWHAZ11673220936779 Two-hybrid
RAP1GAP2YWHAZ11336620936779 Two-hybrid
NEDD4LYWHAZ11691520936779 Two-hybrid
NEDD4LYWHAZ11336620936779 Two-hybrid
WWTR1YWHAZ11336620936779 Two-hybrid
WWTR1YWHAZ11743420936779 Two-hybrid
FHOD1YWHAZ11336620936779 Two-hybrid
FHOD1YWHAZ11887720936779 Two-hybrid
C5orf25YWHAZ11336620936779 Two-hybrid
C5orf25YWHAZ13198120936779 Two-hybrid
FAM13BYWHAZ11336620936779 Two-hybrid
FAM13BYWHAZ11945720936779 Two-hybrid
FAM53CYWHAZ11336620936779 Two-hybrid
FAM53CYWHAZ11945820936779 Two-hybrid
MSL2YWHAZ11336620936779 Two-hybrid
MSL2YWHAZ12046720936779 Two-hybrid
FAM82A2YWHAZ11336620936779 Two-hybrid
FAM82A2YWHAZ12047620936779 Two-hybrid
ZNF839YWHAZ11336620936779 Two-hybrid
ZNF839YWHAZ12089320936779 Two-hybrid
CENPJYWHAZ11336620936779 Two-hybrid
CENPJYWHAZ12093920936779 Two-hybrid
RASAL3YWHAZ12234820936779 Two-hybrid
RASAL3YWHAZ11336620936779 Two-hybrid
WNK1YWHAZ11336620936779 Two-hybrid
WNK1YWHAZ12240320936779 Two-hybrid
WNK2YWHAZ11336620936779 Two-hybrid
WNK2YWHAZ12242320936779 Two-hybrid
CGNL1YWHAZ11336620936779 Two-hybrid
CGNL1YWHAZ12438420936779 Two-hybrid
MADDYWHAZ11336620936779 Two-hybrid
MADDYWHAZ11413620936779 Two-hybrid
EIF3AYWHAZ11336620936779 Two-hybrid
EIF3AYWHAZ11421020936779 Two-hybrid
HDAC9YWHAZ11508320936779 Two-hybrid
HDAC9YWHAZ11336620936779 Two-hybrid
FAM65BYWHAZ11336620936779 Two-hybrid
FAM65BYWHAZ11509820936779 Two-hybrid
KIAA0232YWHAZ11336620936779 Two-hybrid
KIAA0232YWHAZ11512220936779 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
YWHAZEGFR18550315225635 EGFR interacts with 14-3-3-zeta.
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
YWHAZrs964917, rs983583 Gene overview in AlzGene
No data
Gene Symbol Poly Names Gene overview in SZGene
YWHAZrs1470764, rs3019275, rs3105452, rs3134358, rs964917, rs983583 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:109484
  • Data Attributes: MGI curated and HomoloGene calculated
No data