AutismKB 2.0

Annotation Details for ZAP70


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Basic Information Top
Gene Symbol:ZAP70 ( FLJ17670,FLJ17679,SRK,STD,TZK,ZAP-70 )
Gene Full Name: zeta-chain (TCR) associated protein kinase 70kDa
Band: 2q11.2
Quick LinksEntrez ID:7535; OMIM: 176947; Uniprot ID:ZAP70_HUMAN; ENSEMBL ID: ENSG00000115085; HGNC ID: 12858
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001772IEA-immunological synapse-
GO:0005737TAS-cytoplasm12359715
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane12150984
GO:0005886TAS-plasma membrane20135127
GO:0005911IEA-cell-cell junction-
GO:0031234IBA-extrinsic component of cytoplasmic side of plasma membrane-
GO:0042101IDA-T cell receptor complex8176201
GO:0045121IDAcolocalizes_withmembrane raft12150984
GO ID Evidence Qualifier GO_term References
GO:0004713IDA-protein tyrosine kinase activity12447358
GO:0004713NAS-protein tyrosine kinase activity1423621
GO:0004713TAS-protein tyrosine kinase activity-
GO:0004715TAS-non-membrane spanning protein tyrosine kinase activity20135127
GO:0005102IBA-receptor binding-
GO:0005515IPI-protein binding7509083
GO:0005524NAS-ATP binding1423621
GO ID Evidence Qualifier GO_term References
GO:0002250TAS-adaptive immune response20135127
GO:0006468IDA-protein phosphorylation12447358
GO:0006468NAS-protein phosphorylation1423621
GO:0006955IDA-immune response1423621
GO:0007169IBA-transmembrane receptor protein tyrosine kinase signaling pathway-
GO:0018108IDA-peptidyl-tyrosine phosphorylation22732588
GO:0018108IMP-peptidyl-tyrosine phosphorylation23620790
GO:0030217NAS-T cell differentiation8613493
GO:0035556NAS-intracellular signal transduction1423621
GO:0038083IBA-peptidyl-tyrosine autophosphorylation-
GO:0042110TAS-T cell activation20135127
GO:0042113TAS-B cell activation20135127
GO:0042127IBA-regulation of cell proliferation-
GO:0043366IEA-beta selection-
GO:0045059IDA-positive thymic T cell selection7630421
GO:0045060IEA-negative thymic T cell selection-
GO:0045087IBA-innate immune response-
GO:0045582IDA-positive regulation of T cell differentiation7630421
GO:0046638IEA-positive regulation of alpha-beta T cell differentiation-
GO:0046641IEA-positive regulation of alpha-beta T cell proliferation-
GO:0050850IEA-positive regulation of calcium-mediated signaling-
GO:0050852TAS-T cell receptor signaling pathway20135127
GO:0070489TAS-T cell aggregation20135127
GO:0072678TAS-T cell migration20135127
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ZAP70ABL11133677760813 Affinity Capture-Western
ZAP70ABL11065437760813 Affinity Capture-Western
ZAP70ACP111336711976341 Affinity Capture-Western
ZAP70ACP110656811976341 Affinity Capture-Western
ZAP70CBL1133678798643 10078535 Affinity Capture-Western; Co-crystal Structure
ZAP70CBL1073158798643 10078535 Affinity Capture-Western; Co-crystal Structure
ZAP70CBLB11336710074432 Affinity Capture-Western
ZAP70CBLB10731610074432 Affinity Capture-Western
ZAP70CD3E1133677761456 Reconstituted Complex
ZAP70CD3E1073547761456 Reconstituted Complex
ZAP70CD2471073577737297 Affinity Capture-Western
ZAP70CD2471133677737297 Affinity Capture-Western
ZAP70CD41073587539035 Affinity Capture-Western
ZAP70CD41133677539035 Affinity Capture-Western
ZAP70CD51073599378960 Affinity Capture-Western
ZAP70CD51133679378960 Affinity Capture-Western
ZAP70CRK11336710419455 Reconstituted Complex
ZAP70CRK10778810419455 Reconstituted Complex
ZAP70FYN1133677760813 Affinity Capture-Western; Phenotypic Enhancement
ZAP70FYN1088107760813 Affinity Capture-Western; Phenotypic Enhancement
ZAP70GRB21091427629168 Affinity Capture-Western
ZAP70GRB21133677629168 Affinity Capture-Western
ZAP70LCK1133677539035 10318843 Affinity Capture-Western
ZAP70LCK1101247539035 10318843 Affinity Capture-Western
ZAP70LCP21133679047237 Biochemical Activity
ZAP70LCP21101299047237 Biochemical Activity
ZAP70PLCG11133677629168 Affinity Capture-Western
ZAP70PLCG11113517629168 Affinity Capture-Western
ZAP70PTPN61117428638162 Reconstituted Complex
ZAP70PTPN61133678638162 Reconstituted Complex
ZAP70RASA11133677760813 Affinity Capture-Western
ZAP70RASA11118567760813 Affinity Capture-Western
ZAP70SH3BP21133679846481 Affinity Capture-Western; Reconstituted Complex
ZAP70SH3BP21123509846481 Affinity Capture-Western; Reconstituted Complex
ZAP70SHB11235812084069 Affinity Capture-Western; Reconstituted Complex
ZAP70SHB11336712084069 Affinity Capture-Western; Reconstituted Complex
ZAP70SHC11123619685404 Affinity Capture-Western; Biochemical Activity
ZAP70SHC11133679685404 Affinity Capture-Western; Biochemical Activity
ZAP70SLA11336710449770 Affinity Capture-Western
ZAP70SLA11239410449770 Affinity Capture-Western
ZAP70TYROBP1133679490415 Protein-peptide
ZAP70TYROBP1131559490415 Protein-peptide
ZAP70UBC11336718453590 Affinity Capture-Western
ZAP70UBC11316418453590 Affinity Capture-Western
ZAP70VAV11133677798261 Reconstituted Complex
ZAP70VAV11132527798261 Reconstituted Complex
SIT1ZAP7011336710209036 Affinity Capture-Western
SIT1ZAP7011808810209036 Affinity Capture-Western
PAG1ZAP7011336710790433 Reconstituted Complex
PAG1ZAP7012093110790433 Reconstituted Complex
LATZAP7011336711368773 12186560 Biochemical Activity
LATZAP7011797111368773 12186560 Biochemical Activity
GAB2ZAP7011336711572860 Affinity Capture-Western
GAB2ZAP7011518111572860 Affinity Capture-Western
SLA2ZAP7011336711891219 Affinity Capture-Western
SLA2ZAP7012392811891219 Affinity Capture-Western
FCRL3ZAP7011336712051764 Reconstituted Complex
FCRL3ZAP7012542812051764 Reconstituted Complex
DBNLZAP7011336714557276 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
DBNLZAP7011880914557276 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
TUBA1BZAP7011336715084271 Affinity Capture-Western
TUBA1BZAP7011565115084271 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:99613
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050522-257'