AutismKB 2.0

Annotation Details for ZFP36


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Basic Information Top
Gene Symbol:ZFP36 ( G0S24,GOS24,NUP475,RNF162A,TIS11,TTP )
Gene Full Name: zinc finger protein 36, C3H type, homolog (mouse)
Band: 19q13.1
Quick LinksEntrez ID:7538; OMIM: 190700; Uniprot ID:TTP_HUMAN; ENSEMBL ID: ENSG00000128016; HGNC ID: 12862
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000178IDANOT colocalizes_withexosome (RNase complex)11719186
GO:0000932IDA-P-body17369404
GO:0005634IDA-nucleus10330172
GO:0005737IDA-cytoplasm10330172
GO:0005829IDA-cytosol10751406
GO:0005829TAS-cytosol-
GO:0010494IDA-cytoplasmic stress granule15014438
GO:0030014ISScolocalizes_withCCR4-NOT complex-
GO:0030529IDA-intracellular ribonucleoprotein complex15687258
GO:0070578IDAcolocalizes_withRISC-loading complex15766526
GO:0098745IDAcolocalizes_withDcp1-Dcp2 complex16364915
GO:1990904IDA-ribonucleoprotein complex10330172
GO ID Evidence Qualifier GO_term References
GO:0003677IEA-DNA binding-
GO:0003723IDA-RNA binding22658674
GO:0003727TAS-single-stranded RNA binding9703499
GO:0003729IDA-mRNA binding11782475
GO:0005515IPI-protein binding14679154
GO:0017091IDA-AU-rich element binding10330172
GO:0017091IMP-AU-rich element binding21784977
GO:0019899IPI-enzyme binding25038453
GO:0019901IPI-protein kinase binding15014438
GO:0019957IPI-C-C chemokine binding21784977
GO:0031072IDA-heat shock protein binding20221403
GO:0035925IDA-mRNA 3'-UTR AU-rich region binding9703499
GO:0046872IEA-metal ion binding-
GO:0070063ISS-RNA polymerase binding-
GO:0071889IDA-14-3-3 protein binding15014438
GO ID Evidence Qualifier GO_term References
GO:0000122IMP-negative regulation of transcription from RNA polymerase II promoter21784977
GO:0000165IMP-MAPK cascade15187101
GO:0000165ISS-MAPK cascade-
GO:0000288IDA-nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay23644599
GO:0000289IMP-nuclear-transcribed mRNA poly(A) tail shortening23644599
GO:0006402IDA-mRNA catabolic process10330172
GO:0009611IDA-response to wounding27182009
GO:0009611ISS-response to wounding-
GO:0010837IMP-regulation of keratinocyte proliferation27182009
GO:0031086IDA-nuclear-transcribed mRNA catabolic process, deadenylation-independent decay11279239
GO:0032680IDA-regulation of tumor necrosis factor production15014438
GO:0032897IMP-negative regulation of viral transcription14679154
GO:0035278ISS-miRNA mediated inhibition of translation-
GO:0038066ISS-p38MAPK cascade-
GO:0042594IDA-response to starvation15014438
GO:0043488IDA-regulation of mRNA stability9703499
GO:0043488IMP-regulation of mRNA stability15187101
GO:0043488TAS-regulation of mRNA stability-
GO:0044344IDA-cellular response to fibroblast growth factor stimulus20166898
GO:0045085ISS-negative regulation of interleukin-2 biosynthetic process-
GO:0045600ISS-positive regulation of fat cell differentiation-
GO:0045616IMP-regulation of keratinocyte differentiation27182009
GO:0045647IDA-negative regulation of erythrocyte differentiation20702587
GO:0051028IMP-mRNA transport17369404
GO:0060213IDA-positive regulation of nuclear-transcribed mRNA poly(A) tail shortening10330172
GO:0061158IDA-3'-UTR-mediated mRNA destabilization9703499
GO:0061158IMP-3'-UTR-mediated mRNA destabilization14679154
GO:0070935IDA-3'-UTR-mediated mRNA stabilization15014438
GO:0071222IDA-cellular response to lipopolysaccharide14766228
GO:0071222IMP-cellular response to lipopolysaccharide14679154
GO:0071356IDA-cellular response to tumor necrosis factor20166898
GO:0071364IDA-cellular response to epidermal growth factor stimulus20166898
GO:0071385IDA-cellular response to glucocorticoid stimulus20166898
GO:0097011IDA-cellular response to granulocyte macrophage colony-stimulating factor stimulus20166898
GO:1900153IDA-positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay12748283
GO:1900153ISS-positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay-
GO:1901835IDA-positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA16364915
GO:1902172IMP-regulation of keratinocyte apoptotic process27182009
GO:1904246ISS-negative regulation of polynucleotide adenylyltransferase activity-
GO:1904582IMP-positive regulation of intracellular mRNA localization17369404
GO:2000637IMP-positive regulation of gene silencing by miRNA15766526
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ZFP36HDAC111337019738286 Affinity Capture-Western
ZFP36HDAC110931519738286 Affinity Capture-Western
ZFP36HOXC911337020211142 Two-hybrid
ZFP36HOXC910946520211142 Two-hybrid
ZFP36NFKB111337019738286 Affinity Capture-Western
ZFP36NFKB111085719738286 Affinity Capture-Western
ZFP36YWHAB11336111886850 Affinity Capture-Western
ZFP36YWHAB11337011886850 Affinity Capture-Western
ZFP36YWHAH11337011886850 Reconstituted Complex; Two-hybrid
ZFP36YWHAH11336511886850 Reconstituted Complex; Two-hybrid
NUP214ZFP3611337014766228 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NUP214ZFP3611371714766228 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CCDC85BZFP3611337016189514 Two-hybrid
CCDC85BZFP3611619816189514 Two-hybrid
HDAC7ZFP3611961319738286 Affinity Capture-Western
HDAC7ZFP3611337019738286 Affinity Capture-Western
HDAC3ZFP3611436819738286 Affinity Capture-Western
HDAC3ZFP3611337019738286 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:99180
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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