AutismKB 2.0

Annotation Details for TRIM25


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Basic Information Top
Gene Symbol:TRIM25 ( EFP,RNF147,Z147,ZNF147 )
Gene Full Name: tripartite motif-containing 25
Band: 17q23.1
Quick LinksEntrez ID:7706; OMIM: 600453; Uniprot ID:TRI25_HUMAN; ENSEMBL ID: ENSG00000121060; HGNC ID: 12932
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0016604IDA-nuclear body-
GO ID Evidence Qualifier GO_term References
GO:0003700TAS-transcription factor activity, sequence-specific DNA binding8248217
GO:0003723IDA-RNA binding22658674
GO:0004842EXP-ubiquitin-protein transferase activity17392790
GO:0005515IPI-protein binding19454348
GO:0016874IEA-ligase activity-
GO:0045296IDA-cadherin binding25468996
GO:0046872IEA-metal ion binding-
GO:1904264IMP-ubiquitin protein ligase activity involved in ERAD pathway24810856
GO ID Evidence Qualifier GO_term References
GO:0006513IMP-protein monoubiquitination24810856
GO:0016579TAS-protein deubiquitination-
GO:0019985TAS-translesion synthesis-
GO:0030433IEA-ubiquitin-dependent ERAD pathway-
GO:0032480TAS-negative regulation of type I interferon production-
GO:0033280IEA-response to vitamin D-
GO:0036503IMP-ERAD pathway24810856
GO:0042787IMP-protein ubiquitination involved in ubiquitin-dependent protein catabolic process22452784
GO:0043123IDA-positive regulation of I-kappaB kinase/NF-kappaB signaling23077300
GO:0043627IDA-response to estrogen22452784
GO:0045087IDA-innate immune response18248090
GO:0045087TAS-innate immune response-
GO:0046596IDA-regulation of viral entry into host cell18248090
GO:0046597IEA-negative regulation of viral entry into host cell-
GO:0051091IMP-positive regulation of sequence-specific DNA binding transcription factor activity23077300
GO:0051092IMP-positive regulation of NF-kappaB transcription factor activity23077300
GO:0051607IEA-defense response to virus-
GO:0060333TAS-interferon-gamma-mediated signaling pathway-
GO:1902186IMP-regulation of viral release from host cell18248090
GO:1902187IEA-negative regulation of viral release from host cell-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TRIM25ERCC211350016884686 Reconstituted Complex
TRIM25ERCC210838016884686 Reconstituted Complex
TRIM25ESR111350017418098 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
TRIM25ESR110840317418098 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
TRIM25GATA111350020211142 Two-hybrid
TRIM25GATA110889320211142 Two-hybrid
TRIM25SFN11350012075357 Affinity Capture-Western
TRIM25SFN10907212075357 Affinity Capture-Western
TRIM25MEIS211037620211142 Two-hybrid
TRIM25MEIS211350020211142 Two-hybrid
TRIM25PITX211350016884686 20211142 Reconstituted Complex; Two-hybrid
TRIM25PITX211132516884686 20211142 Reconstituted Complex; Two-hybrid
TRIM25RARRES311350018948594 Reconstituted Complex
TRIM25RARRES311185518948594 Reconstituted Complex
TRIM25UBC11350017069755 Affinity Capture-Western
TRIM25UBC11316417069755 Affinity Capture-Western
TRIM25UBE2D111350019549727 Two-hybrid
TRIM25UBE2D111316919549727 Two-hybrid
TRIM25UBE2D211350019549727 Two-hybrid
TRIM25UBE2D211317019549727 Two-hybrid
TRIM25UBE2D311350019549727 Two-hybrid
TRIM25UBE2D311317119549727 Two-hybrid
TRIM25UBE2N11350019549727 Two-hybrid
TRIM25UBE2N11318219549727 Two-hybrid
TRIM25ZNF2411350020211142 Two-hybrid
TRIM25ZNF2411340320211142 Two-hybrid
TRIM25TRIM2511350011331580 Two-hybrid
UBE2L6TRIM2511350012075357 Affinity Capture-Western
UBE2L6TRIM2511467212075357 Affinity Capture-Western
STK38TRIM2511350016884686 Reconstituted Complex
STK38TRIM2511645716884686 Reconstituted Complex
ISG15TRIM2511350017069755 Affinity Capture-Western
ISG15TRIM2511499517069755 Affinity Capture-Western
DDX58TRIM2511350017392790 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
DDX58TRIM2511712117392790 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
UBE2J2TRIM2511350019549727 Two-hybrid
UBE2J2TRIM2512559819549727 Two-hybrid
UBE2D4TRIM2511350019549727 Two-hybrid
UBE2D4TRIM2511964119549727 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:102749
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-797'