AutismKB 2.0

Annotation Details for CACNA1A


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Basic Information Top
Gene Symbol:CACNA1A ( APCA,CACNL1A4,CAV2.1,EA2,FHM,HPCA,MHP,MHP1,SCA6 )
Gene Full Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Band: 19p13.13
Quick LinksEntrez ID:773; OMIM: 601011; Uniprot ID:CAC1A_HUMAN; ENSEMBL ID: ENSG00000141837; HGNC ID: 1388
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus16595610
GO:0005737IDA-cytoplasm16595610
GO:0005886IDA-plasma membrane16595610
GO:0005886TAS-plasma membrane-
GO:0005891IEA-voltage-gated calcium channel complex-
GO:0016021NAS-integral component of membrane10753886
GO:0016021TAS-integral component of membrane16595610
GO:0042995IDA-cell projection16595610
GO ID Evidence Qualifier GO_term References
GO:0005245IDA-voltage-gated calcium channel activity10753886
GO:0005245ISS-voltage-gated calcium channel activity-
GO:0005245TAS-voltage-gated calcium channel activity-
GO:0005262TAS-calcium channel activity-
GO:0005515IPI-protein binding8692999
GO:0008331IDA-high voltage-gated calcium channel activity24836863
GO:0019905IDA-syntaxin binding8692999
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0007204IDA-positive regulation of cytosolic calcium ion concentration10753886
GO:0007204ISS-positive regulation of cytosolic calcium ion concentration-
GO:0008219IDA-cell death16595610
GO:0034765IEA-regulation of ion transmembrane transport-
GO:0050796TAS-regulation of insulin secretion-
GO:0051899TAS-membrane depolarization-
GO:0070588IDA-calcium ion transmembrane transport24836863
GO:0086010IBA-membrane depolarization during action potential-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SYT1CACNA1A1072279303303 Reconstituted Complex
SYT1CACNA1A1127239303303 Reconstituted Complex
CACNB4CACNA1A1072279442082 10212211 Reconstituted Complex
CACNB4CACNA1A1072399442082 10212211 Reconstituted Complex
CABP1CACNA1A10722711865310 14570872 Affinity Capture-Western; Two-hybrid
CABP1CACNA1A11486311865310 14570872 Affinity Capture-Western; Two-hybrid
KDM5BCACNA1A11598419336002 Affinity Capture-MS
KDM5BCACNA1A10722719336002 Affinity Capture-MS
Gene Symbol Interactant Interaction ID References Description
GNB1CACNA1A30091915953418 An unspecified isoform of Cav2.1 interacts with G-beta-1. This interaction was modeled on a demonstrated interaction between Cav2.1 and G-beta-1, both from unspecified species.
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
CACNA1ACACNA1A_STR Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
CACNA1ACACNA1A_3bpSTR Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:109482
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040724-26'